BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

297 related articles for article (PubMed ID: 22045984)

  • 1. Megakaryocyte-specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis.
    Pleines I; Hagedorn I; Gupta S; May F; Chakarova L; van Hengel J; Offermanns S; Krohne G; Kleinschnitz C; Brakebusch C; Nieswandt B
    Blood; 2012 Jan; 119(4):1054-63. PubMed ID: 22045984
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Anti-glycoprotein VI treatment severely compromises hemostasis in mice with reduced alpha2beta1 levels or concomitant aspirin therapy.
    Grüner S; Prostredna M; Aktas B; Moers A; Schulte V; Krieg T; Offermanns S; Eckes B; Nieswandt B
    Circulation; 2004 Nov; 110(18):2946-51. PubMed ID: 15505105
    [TBL] [Abstract][Full Text] [Related]  

  • 3. G13 is an essential mediator of platelet activation in hemostasis and thrombosis.
    Moers A; Nieswandt B; Massberg S; Wettschureck N; Grüner S; Konrad I; Schulte V; Aktas B; Gratacap MP; Simon MI; Gawaz M; Offermanns S
    Nat Med; 2003 Nov; 9(11):1418-22. PubMed ID: 14528298
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Loss of oligophrenin1 leads to uncontrolled Rho activation and increased thrombus formation in mice.
    Fotinos A; Klier M; Gowert NS; Münzer P; Klatt C; Beck S; Borst O; Billuart P; Schaller M; Lang F; Gawaz M; Elvers M
    J Thromb Haemost; 2015 Apr; 13(4):619-30. PubMed ID: 25556321
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Receptor-dependent RhoA activation in G12/G13-deficient cells: genetic evidence for an involvement of Gq/G11.
    Vogt S; Grosse R; Schultz G; Offermanns S
    J Biol Chem; 2003 Aug; 278(31):28743-9. PubMed ID: 12771155
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Disabled-2 is required for efficient hemostasis and platelet activation by thrombin in mice.
    Tsai HJ; Huang CL; Chang YW; Huang DY; Lin CC; Cooper JA; Cheng JC; Tseng CP
    Arterioscler Thromb Vasc Biol; 2014 Nov; 34(11):2404-12. PubMed ID: 25212232
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Pyk2 downstream of G
    Chaudhary PK; Han JS; Jee Y; Lee SH; Kim S
    Biochem Biophys Res Commun; 2020 Jun; 526(3):738-743. PubMed ID: 32265034
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Alterations in Platelet Alpha-Granule Secretion and Adhesion on Collagen under Flow in Mice Lacking the Atypical Rho GTPase RhoBTB3.
    Berger M; Lutz DRJ; Lutz J; Khalil JS; Aburima A; Naseem KM; Rivero F
    Cells; 2019 Feb; 8(2):. PubMed ID: 30754723
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Functional redundancy between RAP1 isoforms in murine platelet production and function.
    Stefanini L; Lee RH; Paul DS; O'Shaughnessy EC; Ghalloussi D; Jones CI; Boulaftali Y; Poe KO; Piatt R; Kechele DO; Caron KM; Hahn KM; Gibbins JM; Bergmeier W
    Blood; 2018 Nov; 132(18):1951-1962. PubMed ID: 30131434
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Leukaemia-associated Rho guanine nucleotide exchange factor (LARG) plays an agonist specific role in platelet function through RhoA activation.
    Zou S; Teixeira AM; Yin M; Xiang Y; Xavier-Ferrucio J; Zhang PX; Hwa J; Min W; Krause DS
    Thromb Haemost; 2016 Aug; 116(3):506-16. PubMed ID: 27345948
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Leukemia-associated Rho guanine-nucleotide exchange factor is not critical for RhoA regulation, yet is important for platelet activation and thrombosis in mice.
    Williams CM; Harper MT; Goggs R; Walsh TG; Offermanns S; Poole AW
    J Thromb Haemost; 2015 Nov; 13(11):2102-7. PubMed ID: 26334261
    [TBL] [Abstract][Full Text] [Related]  

  • 12. NLRP3 regulates platelet integrin αIIbβ3 outside-in signaling, hemostasis and arterial thrombosis.
    Qiao J; Wu X; Luo Q; Wei G; Xu M; Wu Y; Liu Y; Li X; Zi J; Ju W; Fu L; Chen C; Wu Q; Zhu S; Qi K; Li D; Li Z; Andrews RK; Zeng L; Gardiner EE; Xu K
    Haematologica; 2018 Sep; 103(9):1568-1576. PubMed ID: 29794149
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Defective tubulin organization and proplatelet formation in murine megakaryocytes lacking Rac1 and Cdc42.
    Pleines I; Dütting S; Cherpokova D; Eckly A; Meyer I; Morowski M; Krohne G; Schulze H; Gachet C; Debili N; Brakebusch C; Nieswandt B
    Blood; 2013 Oct; 122(18):3178-87. PubMed ID: 23861250
    [TBL] [Abstract][Full Text] [Related]  

  • 14. ADAP deficiency impairs megakaryocyte polarization with ectopic proplatelet release and causes microthrombocytopenia.
    Spindler M; van Eeuwijk JMM; Schurr Y; Nurden P; Nieswandt B; Stegner D; Reinhold A; Bender M
    Blood; 2018 Aug; 132(6):635-646. PubMed ID: 29950291
    [TBL] [Abstract][Full Text] [Related]  

  • 15. CK2β regulates thrombopoiesis and Ca
    Münzer P; Walker-Allgaier B; Geue S; Langhauser F; Geuss E; Stegner D; Aurbach K; Semeniak D; Chatterjee M; Gonzalez Menendez I; Märklin M; Quintanilla-Martinez L; Salih HR; Litchfield DW; Buchou T; Kleinschnitz C; Lang F; Nieswandt B; Pleines I; Schulze H; Gawaz M; Borst O
    Blood; 2017 Dec; 130(25):2774-2785. PubMed ID: 28928125
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Characterization of a Novel Integrin Binding Protein, VPS33B, Which Is Important for Platelet Activation and In Vivo Thrombosis and Hemostasis.
    Xiang B; Zhang G; Ye S; Zhang R; Huang C; Liu J; Tao M; Ruan C; Smyth SS; Whiteheart SW; Li Z
    Circulation; 2015 Dec; 132(24):2334-44. PubMed ID: 26399659
    [TBL] [Abstract][Full Text] [Related]  

  • 17. RhoA is essential for maintaining normal megakaryocyte ploidy and platelet generation.
    Suzuki A; Shin JW; Wang Y; Min SH; Poncz M; Choi JK; Discher DE; Carpenter CL; Lian L; Zhao L; Wang Y; Abrams CS
    PLoS One; 2013; 8(7):e69315. PubMed ID: 23935982
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Megakaryocyte-restricted MYH9 inactivation dramatically affects hemostasis while preserving platelet aggregation and secretion.
    Léon C; Eckly A; Hechler B; Aleil B; Freund M; Ravanat C; Jourdain M; Nonne C; Weber J; Tiedt R; Gratacap MP; Severin S; Cazenave JP; Lanza F; Skoda R; Gachet C
    Blood; 2007 Nov; 110(9):3183-91. PubMed ID: 17664350
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Targeted gene inactivation reveals a functional role of calpain-1 in platelet spreading.
    Kuchay SM; Wieschhaus AJ; Marinkovic M; Herman IM; Chishti AH
    J Thromb Haemost; 2012 Jun; 10(6):1120-32. PubMed ID: 22458296
    [TBL] [Abstract][Full Text] [Related]  

  • 20. PAK Membrane Translocation and Phosphorylation Regulate Platelet Aggregation Downstream of Gi and G12/13 Pathways.
    Zhang J; Zhang Y; Zheng S; Liu Y; Chang L; Pan G; Hu L; Zhang S; Liu J; Kim S; Dong J; Ding Z
    Thromb Haemost; 2020 Nov; 120(11):1536-1547. PubMed ID: 32854120
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.