These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

209 related articles for article (PubMed ID: 22053189)

  • 1. Crystal structure of thrombin in complex with S-variegin: insights of a novel mechanism of inhibition and design of tunable thrombin inhibitors.
    Koh CY; Kumar S; Kazimirova M; Nuttall PA; Radhakrishnan UP; Kim S; Jagadeeswaran P; Imamura T; Mizuguchi J; Iwanaga S; Swaminathan K; Kini RM
    PLoS One; 2011; 6(10):e26367. PubMed ID: 22053189
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Variegin, a novel fast and tight binding thrombin inhibitor from the tropical bont tick.
    Koh CY; Kazimirova M; Trimnell A; Takac P; Labuda M; Nuttall PA; Kini RM
    J Biol Chem; 2007 Oct; 282(40):29101-13. PubMed ID: 17684009
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structural and Functional Characterization of Hirudin P6 Derived Novel Bivalent Thrombin Inhibitors - Studying the Effect of Linker Length and Glycosylation on Their Function.
    Shabareesh P; Kaur KJ
    Chem Biol Drug Des; 2016 Jul; 88(1):129-41. PubMed ID: 26850929
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Unique thrombin inhibition mechanism by anophelin, an anticoagulant from the malaria vector.
    Figueiredo AC; de Sanctis D; Gutiérrez-Gallego R; Cereija TB; Macedo-Ribeiro S; Fuentes-Prior P; Pereira PJ
    Proc Natl Acad Sci U S A; 2012 Dec; 109(52):E3649-58. PubMed ID: 23223529
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Anophelin: kinetics and mechanism of thrombin inhibition.
    Francischetti IM; Valenzuela JG; Ribeiro JM
    Biochemistry; 1999 Dec; 38(50):16678-85. PubMed ID: 10600131
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Bifunctional peptide boronate inhibitors of thrombin: crystallographic analysis of inhibition enhanced by linkage to an exosite 1 binding peptide.
    Skordalakes E; Elgendy S; Goodwin CA; Green D; Scully MF; Kakkar VV; Freyssinet JM; Dodson G; Deadman JJ
    Biochemistry; 1998 Oct; 37(41):14420-7. PubMed ID: 9772168
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structural and functional studies of differentially O-glycosylated analogs of a thrombin inhibitory peptide - variegin.
    Shabareesh PRV; Kumar A; Salunke DM; Kaur KJ
    J Pept Sci; 2017 Dec; 23(12):880-888. PubMed ID: 29110415
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Human alpha-thrombin inhibition by the active site titrant N alpha-(N,N-dimethylcarbamoyl)-alpha-azalysine p-nitrophenyl ester: a comparative kinetic and X-ray crystallographic study.
    Nardini M; Pesce A; Rizzi M; Casale E; Ferraccioli R; Balliano G; Milla P; Ascenzi P; Bolognesi M
    J Mol Biol; 1996 May; 258(5):851-9. PubMed ID: 8637015
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Development of bioanalytical assays for variegin, a peptide-based bivalent direct thrombin inhibitor.
    Shih N; de Carvalho LP; Lee YH; Rocha MM; Pereira Barbosa AH; A de Sousa JM; de C Carvalho AC; Kini RM; Chan MY
    Bioanalysis; 2017 May; 9(9):693-705. PubMed ID: 28488882
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis, structure, and structure-activity relationships of divalent thrombin inhibitors containing an alpha-keto-amide transition-state mimetic.
    Krishnan R; Tulinsky A; Vlasuk GP; Pearson D; Vallar P; Bergum P; Brunck TK; Ripka WC
    Protein Sci; 1996 Mar; 5(3):422-33. PubMed ID: 8868478
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Avathrin: a novel thrombin inhibitor derived from a multicopy precursor in the salivary glands of the ixodid tick,
    Iyer JK; Koh CY; Kazimirova M; Roller L; Jobichen C; Swaminathan K; Mizuguchi J; Iwanaga S; Nuttall PA; Chan MY; Kini RM
    FASEB J; 2017 Jul; 31(7):2981-2995. PubMed ID: 28363953
    [TBL] [Abstract][Full Text] [Related]  

  • 12. From natural to synthetic multisite thrombin inhibitors.
    Lombardi A; De Simone G; Galdiero S; Staiano N; Nastri F; Pavone V
    Biopolymers; 1999; 51(1):19-39. PubMed ID: 10380350
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structure of a retro-binding peptide inhibitor complexed with human alpha-thrombin.
    Tabernero L; Chang CY; Ohringer SL; Lau WF; Iwanowicz EJ; Han WC; Wang TC; Seiler SM; Roberts DG; Sack JS
    J Mol Biol; 1995 Feb; 246(1):14-20. PubMed ID: 7853394
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The tick-derived anticoagulant madanin is processed by thrombin and factor Xa.
    Figueiredo AC; de Sanctis D; Pereira PJ
    PLoS One; 2013; 8(8):e71866. PubMed ID: 23951260
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The isomorphous structures of prethrombin2, hirugen-, and PPACK-thrombin: changes accompanying activation and exosite binding to thrombin.
    Vijayalakshmi J; Padmanabhan KP; Mann KG; Tulinsky A
    Protein Sci; 1994 Dec; 3(12):2254-71. PubMed ID: 7756983
    [TBL] [Abstract][Full Text] [Related]  

  • 16. G-Quadruplex Aptamers to Human Thrombin Versus Other Direct Thrombin Inhibitors: The Focus on Mechanism of Action and Drug Efficiency as Anticoagulants.
    Zavyalova E; Ustinov N; Golovin A; Pavlova G; Kopylov A
    Curr Med Chem; 2016; 23(21):2230-44. PubMed ID: 27183984
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Probing the hirudin-thrombin interaction by incorporation of noncoded amino acids and molecular dynamics simulation.
    De Filippis V; Colombo G; Russo I; Spadari B; Fontana A
    Biochemistry; 2002 Nov; 41(46):13556-69. PubMed ID: 12427016
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Structure of thrombin complexed with selective non-electrophilic inhibitors having cyclohexyl moieties at P1.
    Krishnan R; Mochalkin I; Arni R; Tulinsky A
    Acta Crystallogr D Biol Crystallogr; 2000 Mar; 56(Pt 3):294-303. PubMed ID: 10713516
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Structural basis of thrombin-mediated factor V activation: the Glu666-Glu672 sequence is critical for processing at the heavy chain-B domain junction.
    Corral-Rodríguez MÁ; Bock PE; Hernández-Carvajal E; Gutiérrez-Gallego R; Fuentes-Prior P
    Blood; 2011 Jun; 117(26):7164-73. PubMed ID: 21555742
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Electrostatic steering and ionic tethering in the formation of thrombin-hirudin complexes: the role of the thrombin anion-binding exosite-I.
    Myles T; Le Bonniec BF; Betz A; Stone SR
    Biochemistry; 2001 Apr; 40(16):4972-9. PubMed ID: 11305913
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.