231 related articles for article (PubMed ID: 22053912)
1. Aldo-keto reductases protect lung adenocarcinoma cells from the acute toxicity of B[a]P-7,8-trans-dihydrodiol.
Abedin Z; Sen S; Field J
Chem Res Toxicol; 2012 Jan; 25(1):113-21. PubMed ID: 22053912
[TBL] [Abstract][Full Text] [Related]
2. Specificity of human aldo-keto reductases, NAD(P)H:quinone oxidoreductase, and carbonyl reductases to redox-cycle polycyclic aromatic hydrocarbon diones and 4-hydroxyequilenin-o-quinone.
Shultz CA; Quinn AM; Park JH; Harvey RG; Bolton JL; Maser E; Penning TM
Chem Res Toxicol; 2011 Dec; 24(12):2153-66. PubMed ID: 21910479
[TBL] [Abstract][Full Text] [Related]
3. Evidence for the aldo-keto reductase pathway of polycyclic aromatic trans-dihydrodiol activation in human lung A549 cells.
Park JH; Mangal D; Tacka KA; Quinn AM; Harvey RG; Blair IA; Penning TM
Proc Natl Acad Sci U S A; 2008 May; 105(19):6846-51. PubMed ID: 18474869
[TBL] [Abstract][Full Text] [Related]
4. Reactive oxygen species generated by PAH o-quinones cause change-in-function mutations in p53.
Yu D; Berlin JA; Penning TM; Field J
Chem Res Toxicol; 2002 Jun; 15(6):832-42. PubMed ID: 12067251
[TBL] [Abstract][Full Text] [Related]
5. Activation of polycyclic aromatic hydrocarbon trans-dihydrodiol proximate carcinogens by human aldo-keto reductase (AKR1C) enzymes and their functional overexpression in human lung carcinoma (A549) cells.
Palackal NT; Lee SH; Harvey RG; Blair IA; Penning TM
J Biol Chem; 2002 Jul; 277(27):24799-808. PubMed ID: 11978787
[TBL] [Abstract][Full Text] [Related]
6. The ubiquitous aldehyde reductase (AKR1A1) oxidizes proximate carcinogen trans-dihydrodiols to o-quinones: potential role in polycyclic aromatic hydrocarbon activation.
Palackal NT; Burczynski ME; Harvey RG; Penning TM
Biochemistry; 2001 Sep; 40(36):10901-10. PubMed ID: 11535067
[TBL] [Abstract][Full Text] [Related]
7. Comparison of p53 mutations induced by PAH o-quinones with those caused by anti-benzo[a]pyrene diol epoxide in vitro: role of reactive oxygen and biological selection.
Shen YM; Troxel AB; Vedantam S; Penning TM; Field J
Chem Res Toxicol; 2006 Nov; 19(11):1441-50. PubMed ID: 17112231
[TBL] [Abstract][Full Text] [Related]
8. Comparisons of (+/-)-benzo[a]pyrene-trans-7,8-dihydrodiol activation by human cytochrome P450 and aldo-keto reductase enzymes: effect of redox state and expression levels.
Quinn AM; Penning TM
Chem Res Toxicol; 2008 May; 21(5):1086-94. PubMed ID: 18402469
[TBL] [Abstract][Full Text] [Related]
9. Human aldo-keto reductases and the metabolic activation of polycyclic aromatic hydrocarbons.
Penning TM
Chem Res Toxicol; 2014 Nov; 27(11):1901-17. PubMed ID: 25279998
[TBL] [Abstract][Full Text] [Related]
10. The pattern of p53 mutations caused by PAH o-quinones is driven by 8-oxo-dGuo formation while the spectrum of mutations is determined by biological selection for dominance.
Park JH; Gelhaus S; Vedantam S; Oliva AL; Batra A; Blair IA; Troxel AB; Field J; Penning TM
Chem Res Toxicol; 2008 May; 21(5):1039-49. PubMed ID: 18489080
[TBL] [Abstract][Full Text] [Related]
11. Competing roles of cytochrome P450 1A1/1B1 and aldo-keto reductase 1A1 in the metabolic activation of (+/-)-7,8-dihydroxy-7,8-dihydro-benzo[a]pyrene in human bronchoalveolar cell extracts.
Jiang H; Shen YM; Quinn AM; Penning TM
Chem Res Toxicol; 2005 Feb; 18(2):365-74. PubMed ID: 15720144
[TBL] [Abstract][Full Text] [Related]
12. Dihydrodiol dehydrogenase and its role in polycyclic aromatic hydrocarbon metabolism.
Penning TM
Chem Biol Interact; 1993 Oct; 89(1):1-34. PubMed ID: 8221964
[TBL] [Abstract][Full Text] [Related]
13. Competing roles of aldo-keto reductase 1A1 and cytochrome P4501B1 in benzo[a]pyrene-7,8-diol activation in human bronchoalveolar H358 cells: role of AKRs in P4501B1 induction.
Jiang H; Vudathala DK; Blair IA; Penning TM
Chem Res Toxicol; 2006 Jan; 19(1):68-78. PubMed ID: 16411658
[TBL] [Abstract][Full Text] [Related]
14. Metabolism of benzo[a]pyrene in human bronchoalveolar H358 cells using liquid chromatography-mass spectrometry.
Jiang H; Gelhaus SL; Mangal D; Harvey RG; Blair IA; Penning TM
Chem Res Toxicol; 2007 Sep; 20(9):1331-41. PubMed ID: 17702526
[TBL] [Abstract][Full Text] [Related]
15. Aldo-keto reductase- and cytochrome P450-dependent formation of benzo[a]pyrene-derived DNA adducts in human bronchoalveolar cells.
Ruan Q; Gelhaus SL; Penning TM; Harvey RG; Blair IA
Chem Res Toxicol; 2007 Mar; 20(3):424-31. PubMed ID: 17295519
[TBL] [Abstract][Full Text] [Related]
16. Polycyclic aromatic hydrocarbon (PAH) o-quinones produced by the aldo-keto-reductases (AKRs) generate abasic sites, oxidized pyrimidines, and 8-oxo-dGuo via reactive oxygen species.
Park JH; Troxel AB; Harvey RG; Penning TM
Chem Res Toxicol; 2006 May; 19(5):719-28. PubMed ID: 16696575
[TBL] [Abstract][Full Text] [Related]
17. Alterations in human B cell calcium homeostasis by polycyclic aromatic hydrocarbons: possible associations with cytochrome P450 metabolism and increased protein tyrosine phosphorylation.
Mounho BJ; Burchiel SW
Toxicol Appl Pharmacol; 1998 Mar; 149(1):80-9. PubMed ID: 9512730
[TBL] [Abstract][Full Text] [Related]
18. Oxidation of PAH trans-dihydrodiols by human aldo-keto reductase AKR1B10.
Quinn AM; Harvey RG; Penning TM
Chem Res Toxicol; 2008 Nov; 21(11):2207-15. PubMed ID: 18788756
[TBL] [Abstract][Full Text] [Related]
19. Genotoxic polycyclic aromatic hydrocarbon ortho-quinones generated by aldo-keto reductases induce CYP1A1 via nuclear translocation of the aryl hydrocarbon receptor.
Burczynski ME; Penning TM
Cancer Res; 2000 Feb; 60(4):908-15. PubMed ID: 10706104
[TBL] [Abstract][Full Text] [Related]
20. Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase.
Burczynski ME; Lin HK; Penning TM
Cancer Res; 1999 Feb; 59(3):607-14. PubMed ID: 9973208
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
