BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

120 related articles for article (PubMed ID: 22056432)

  • 1. Characterization and functional modification of StaC and RebC, which are involved in the pyrrole oxidation of indolocarbazole biosynthesis.
    Asamizu S; Shiro Y; Igarashi Y; Nagano S; Onaka H
    Biosci Biotechnol Biochem; 2011; 75(11):2184-93. PubMed ID: 22056432
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Staurosporine and rebeccamycin aglycones are assembled by the oxidative action of StaP, StaC, and RebC on chromopyrrolic acid.
    Howard-Jones AR; Walsh CT
    J Am Chem Soc; 2006 Sep; 128(37):12289-98. PubMed ID: 16967980
    [TBL] [Abstract][Full Text] [Related]  

  • 3. An unusual role for a mobile flavin in StaC-like indolocarbazole biosynthetic enzymes.
    Goldman PJ; Ryan KS; Hamill MJ; Howard-Jones AR; Walsh CT; Elliott SJ; Drennan CL
    Chem Biol; 2012 Jul; 19(7):855-65. PubMed ID: 22840773
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Rebeccamycin and staurosporine biosynthesis: insight into the mechanisms of the flavin-dependent monooxygenases RebC and StaC.
    Groom K; Bhattacharya A; Zechel DL
    Chembiochem; 2011 Feb; 12(3):396-400. PubMed ID: 21290541
    [No Abstract]   [Full Text] [Related]  

  • 5. Important role of a LAL regulator StaR in the staurosporine biosynthesis and high-production of Streptomyces fradiae CGMCC 4.576.
    Guan H; Li Y; Zheng J; Liu N; Zhang J; Tan H
    Sci China Life Sci; 2019 Dec; 62(12):1638-1654. PubMed ID: 31820200
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Combinatorial biosynthesis of antitumor indolocarbazole compounds.
    Sánchez C; Zhu L; Braña AF; Salas AP; Rohr J; Méndez C; Salas JA
    Proc Natl Acad Sci U S A; 2005 Jan; 102(2):461-6. PubMed ID: 15625109
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Reevaluation of the violacein biosynthetic pathway and its relationship to indolocarbazole biosynthesis.
    Sánchez C; Braña AF; Méndez C; Salas JA
    Chembiochem; 2006 Aug; 7(8):1231-40. PubMed ID: 16874749
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Crystallographic trapping in the rebeccamycin biosynthetic enzyme RebC.
    Ryan KS; Howard-Jones AR; Hamill MJ; Elliott SJ; Walsh CT; Drennan CL
    Proc Natl Acad Sci U S A; 2007 Sep; 104(39):15311-6. PubMed ID: 17873060
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Expansion of bisindole biosynthetic pathways by combinatorial construction.
    Du YL; Ryan KS
    ACS Synth Biol; 2015 Jun; 4(6):682-8. PubMed ID: 25548949
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Genetic organization of the biosynthetic gene cluster for the indolocarbazole K-252a in Nonomuraea longicatena JCM 11136.
    Kim SY; Park JS; Chae CS; Hyun CG; Choi BW; Shin J; Oh KB
    Appl Microbiol Biotechnol; 2007 Jul; 75(5):1119-26. PubMed ID: 17396254
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Deciphering the late steps in the biosynthesis of the anti-tumour indolocarbazole staurosporine: sugar donor substrate flexibility of the StaG glycosyltransferase.
    Salas AP; Zhu L; Sánchez C; Braña AF; Rohr J; Méndez C; Salas JA
    Mol Microbiol; 2005 Oct; 58(1):17-27. PubMed ID: 16164546
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Engineering biosynthetic pathways to generate antitumor indolocarbazole derivatives.
    Sánchez C; Méndez C; Salas JA
    J Ind Microbiol Biotechnol; 2006 Jul; 33(7):560-8. PubMed ID: 16491358
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Characterization of the biosynthetic gene cluster of rebeccamycin from Lechevalieria aerocolonigenes ATCC 39243.
    Onaka H; Taniguchi S; Igarashi Y; Furumai T
    Biosci Biotechnol Biochem; 2003 Jan; 67(1):127-38. PubMed ID: 12619684
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Molecular cloning, sequence analysis and functional characterization of the gene cluster for biosynthesis of K-252a and its analogs.
    Chiu HT; Chen YL; Chen CY; Jin C; Lee MN; Lin YC
    Mol Biosyst; 2009 Oct; 5(10):1180-91. PubMed ID: 19756308
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The FAD cofactor of RebC shifts to an IN conformation upon flavin reduction.
    Ryan KS; Chakraborty S; Howard-Jones AR; Walsh CT; Ballou DP; Drennan CL
    Biochemistry; 2008 Dec; 47(51):13506-13. PubMed ID: 19035832
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Crystal structures and catalytic mechanism of cytochrome P450 StaP that produces the indolocarbazole skeleton.
    Makino M; Sugimoto H; Shiro Y; Asamizu S; Onaka H; Nagano S
    Proc Natl Acad Sci U S A; 2007 Jul; 104(28):11591-6. PubMed ID: 17606921
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Biosynthetic gene cluster for the cladoniamides, bis-indoles with a rearranged scaffold.
    Ryan KS
    PLoS One; 2011; 6(8):e23694. PubMed ID: 21876764
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Crystal structures of two aromatic hydroxylases involved in the early tailoring steps of angucycline biosynthesis.
    Koskiniemi H; Metsä-Ketelä M; Dobritzsch D; Kallio P; Korhonen H; Mäntsälä P; Schneider G; Niemi J
    J Mol Biol; 2007 Sep; 372(3):633-48. PubMed ID: 17669423
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Robust in vitro activity of RebF and RebH, a two-component reductase/halogenase, generating 7-chlorotryptophan during rebeccamycin biosynthesis.
    Yeh E; Garneau S; Walsh CT
    Proc Natl Acad Sci U S A; 2005 Mar; 102(11):3960-5. PubMed ID: 15743914
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Molecular analysis of the rebeccamycin L-amino acid oxidase from Lechevalieria aerocolonigenes ATCC 39243.
    Nishizawa T; Aldrich CC; Sherman DH
    J Bacteriol; 2005 Mar; 187(6):2084-92. PubMed ID: 15743957
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.