These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

118 related articles for article (PubMed ID: 22061640)

  • 1. Discovery of 4-aminomethylphenylacetic acids as γ-secretase modulators via a scaffold design approach.
    Xin Z; Peng H; Zhang A; Talreja T; Kumaravel G; Xu L; Rohde E; Jung MY; Shackett MN; Kocisko D; Chollate S; Dunah AW; Snodgrass-Belt PA; Arnold HM; Taveras AG; Rhodes KJ; Scannevin RH
    Bioorg Med Chem Lett; 2011 Dec; 21(24):7277-80. PubMed ID: 22061640
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Design and synthesis of an aminopiperidine series of γ-secretase modulators.
    Kobayashi T; Iwama S; Fusano A; Kato Y; Ikeda A; Teranishi Y; Nishihara A; Tobe M
    Bioorg Med Chem Lett; 2014 Jan; 24(1):378-81. PubMed ID: 24269163
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Exploring the chemical space of gamma-secretase modulators.
    Zettl H; Weggen S; Schneider P; Schneider G
    Trends Pharmacol Sci; 2010 Sep; 31(9):402-10. PubMed ID: 20591508
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Triazoles as γ-secretase modulators.
    Fischer C; Zultanski SL; Zhou H; Methot JL; Brown WC; Mampreian DM; Schell AJ; Shah S; Nuthall H; Hughes BL; Smotrov N; Kenific CM; Cruz JC; Walker D; Bouthillette M; Nikov GN; Savage DF; Jeliazkova-Mecheva VV; Diaz D; Szewczak AA; Bays N; Middleton RE; Munoz B; Shearman MS
    Bioorg Med Chem Lett; 2011 Jul; 21(13):4083-7. PubMed ID: 21616665
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Piperidine-derived gamma-secretase modulators.
    Hall A; Elliott RL; Giblin GM; Hussain I; Musgrave J; Naylor A; Sasse R; Smith B
    Bioorg Med Chem Lett; 2010 Feb; 20(3):1306-11. PubMed ID: 20056541
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Lead optimization of 4,4-biaryl piperidine amides as γ-secretase inhibitors.
    Close J; Heidebrecht R; Hendrix J; Li C; Munoz B; Surdi L; Kattar S; Tempest P; Moses P; Geng X; Hughes B; Smotrov N; Moxham C; Chapnick J; Kariv I; Nikov G; Burke JE; Deshmukh S; Jeliazkova-Mecheva V; Leach JK; Diaz D; Xu L; Yang Z; Kwei G; Moy L; Shah S; Tanga F; Kenefic C; Savage D; Shearman M; Ball RG; McNevin MJ; Markarewicz A; Miller T
    Bioorg Med Chem Lett; 2012 May; 22(9):3203-7. PubMed ID: 22483609
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Dynamics of Aβ42 reduction in plasma, CSF and brain of rats treated with the γ-secretase modulator, GSM-10h.
    Hawkins J; Harrison DC; Ahmed S; Davis RP; Chapman T; Marshall I; Smith B; Mead TL; Medhurst A; Giblin GM; Hall A; Gonzalez MI; Richardson J; Hussain I
    Neurodegener Dis; 2011; 8(6):455-64. PubMed ID: 21389687
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Combining an amyloid-beta (Aβ) cleaving enzyme inhibitor with a γ-secretase modulator results in an additive reduction of Aβ production.
    Strömberg K; Eketjäll S; Georgievska B; Tunblad K; Eliason K; Olsson F; Radesäter AC; Klintenberg R; Arvidsson PI; von Berg S; Fälting J; Cowburn RF; Dabrowski M
    FEBS J; 2015 Jan; 282(1):65-73. PubMed ID: 25303711
    [TBL] [Abstract][Full Text] [Related]  

  • 9. NSAID-derived γ-secretase modulation requires an acidic moiety on the carbazole scaffold.
    Zall A; Kieser D; Höttecke N; Naumann EC; Thomaszewski B; Schneider K; Steinbacher DT; Schubenel R; Masur S; Baumann K; Schmidt B
    Bioorg Med Chem; 2011 Aug; 19(16):4903-9. PubMed ID: 21763147
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Amelioration of cognitive deficits in plaque-bearing Alzheimer's disease model mice through selective reduction of nascent soluble Aβ42 without affecting other Aβ pools.
    Mitani Y; Yarimizu J; Akashiba H; Shitaka Y; Ni K; Matsuoka N
    J Neurochem; 2013 May; 125(3):465-72. PubMed ID: 23240999
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Design and synthesis of dihydrobenzofuran amides as orally bioavailable, centrally active γ-secretase modulators.
    Pettersson M; Johnson DS; Subramanyam C; Bales KR; am Ende CW; Fish BA; Green ME; Kauffman GW; Lira R; Mullins PB; Navaratnam T; Sakya SM; Stiff CM; Tran TP; Vetelino BC; Xie L; Zhang L; Pustilnik LR; Wood KM; O'Donnell CJ
    Bioorg Med Chem Lett; 2012 Apr; 22(8):2906-11. PubMed ID: 22429469
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Fluorinated piperidine acetic acids as gamma-secretase modulators.
    Stanton MG; Hubbs J; Sloman D; Hamblett C; Andrade P; Angagaw M; Bi G; Black RM; Crispino J; Cruz JC; Fan E; Farris G; Hughes BL; Kenific CM; Middleton RE; Nikov G; Sajonz P; Shah S; Shomer N; Szewczak AA; Tanga F; Tudge MT; Shearman M; Munoz B
    Bioorg Med Chem Lett; 2010 Jan; 20(2):755-8. PubMed ID: 20005099
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Discovery and X-ray crystallographic analysis of a spiropiperidine iminohydantoin inhibitor of beta-secretase.
    Barrow JC; Stauffer SR; Rittle KE; Ngo PL; Yang Z; Selnick HG; Graham SL; Munshi S; McGaughey GB; Holloway MK; Simon AJ; Price EA; Sankaranarayanan S; Colussi D; Tugusheva K; Lai MT; Espeseth AS; Xu M; Huang Q; Wolfe A; Pietrak B; Zuck P; Levorse DA; Hazuda D; Vacca JP
    J Med Chem; 2008 Oct; 51(20):6259-62. PubMed ID: 18811140
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Discovery of novel 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine derivatives as γ-secretase modulators (Part 2).
    Takai T; Koike T; Nakamura M; Kajita Y; Yamashita T; Taya N; Tsukamoto T; Watanabe T; Murakami K; Igari T; Kamata M
    Bioorg Med Chem; 2016 Jul; 24(14):3192-206. PubMed ID: 27255179
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Design, synthesis and structure-activity relationship of novel [3.3.1] bicyclic sulfonamide-pyrazoles as potent γ-secretase inhibitors.
    Aubele DL; Truong AP; Dressen DB; Probst GD; Bowers S; Mattson MN; Semko CM; Sun M; Garofalo AW; Konradi AW; Sham HL; Zmolek W; Wong K; Goldbach E; Quinn KP; Sauer JM; Brigham EF; Wallace W; Nguyen L; Bova MP; Hemphill SS; Basi G
    Bioorg Med Chem Lett; 2011 Oct; 21(19):5791-4. PubMed ID: 21885276
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Gamma-secretase modulation and its promise for Alzheimer's disease: a medicinal chemistry perspective.
    Peretto I; La Porta E
    Curr Top Med Chem; 2008; 8(1):38-46. PubMed ID: 18220931
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Gamma-secretase modulation with Abeta42-lowering nonsteroidal anti-inflammatory drugs and derived compounds.
    Czirr E; Weggen S
    Neurodegener Dis; 2006; 3(4-5):298-304. PubMed ID: 17047371
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Discovery of novel 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine derivatives as γ-secretase modulators.
    Takai T; Hoashi Y; Tomata Y; Morimoto S; Nakamura M; Watanabe T; Igari T; Koike T
    Bioorg Med Chem Lett; 2015 Oct; 25(19):4245-9. PubMed ID: 26298496
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Iminoheterocycles as gamma-secretase modulators.
    Caldwell JP; Bennett CE; McCracken TM; Mazzola RD; Bara T; Buevich A; Burnett DA; Chu I; Cohen-Williams M; Josein H; Hyde L; Lee J; McKittrick B; Song L; Terracina G; Voigt J; Zhang L; Zhu Z
    Bioorg Med Chem Lett; 2010 Sep; 20(18):5380-4. PubMed ID: 20724152
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity.
    Weggen S; Eriksen JL; Das P; Sagi SA; Wang R; Pietrzik CU; Findlay KA; Smith TE; Murphy MP; Bulter T; Kang DE; Marquez-Sterling N; Golde TE; Koo EH
    Nature; 2001 Nov; 414(6860):212-6. PubMed ID: 11700559
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.