These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

359 related articles for article (PubMed ID: 22065587)

  • 1. 3-Formylchromone interacts with cysteine 38 in p65 protein and with cysteine 179 in IκBα kinase, leading to down-regulation of nuclear factor-κB (NF-κB)-regulated gene products and sensitization of tumor cells.
    Yadav VR; Prasad S; Gupta SC; Sung B; Phatak SS; Zhang S; Aggarwal BB
    J Biol Chem; 2012 Jan; 287(1):245-256. PubMed ID: 22065587
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Modification of the cysteine residues in IkappaBalpha kinase and NF-kappaB (p65) by xanthohumol leads to suppression of NF-kappaB-regulated gene products and potentiation of apoptosis in leukemia cells.
    Harikumar KB; Kunnumakkara AB; Ahn KS; Anand P; Krishnan S; Guha S; Aggarwal BB
    Blood; 2009 Feb; 113(9):2003-13. PubMed ID: 18952893
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Fisetin, an inhibitor of cyclin-dependent kinase 6, down-regulates nuclear factor-kappaB-regulated cell proliferation, antiapoptotic and metastatic gene products through the suppression of TAK-1 and receptor-interacting protein-regulated IkappaBalpha kinase activation.
    Sung B; Pandey MK; Aggarwal BB
    Mol Pharmacol; 2007 Jun; 71(6):1703-14. PubMed ID: 17387141
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Berberine modifies cysteine 179 of IkappaBalpha kinase, suppresses nuclear factor-kappaB-regulated antiapoptotic gene products, and potentiates apoptosis.
    Pandey MK; Sung B; Kunnumakkara AB; Sethi G; Chaturvedi MM; Aggarwal BB
    Cancer Res; 2008 Jul; 68(13):5370-9. PubMed ID: 18593939
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Pinitol targets nuclear factor-kappaB activation pathway leading to inhibition of gene products associated with proliferation, apoptosis, invasion, and angiogenesis.
    Sethi G; Ahn KS; Sung B; Aggarwal BB
    Mol Cancer Ther; 2008 Jun; 7(6):1604-14. PubMed ID: 18566231
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Evodiamine abolishes constitutive and inducible NF-kappaB activation by inhibiting IkappaBalpha kinase activation, thereby suppressing NF-kappaB-regulated antiapoptotic and metastatic gene expression, up-regulating apoptosis, and inhibiting invasion.
    Takada Y; Kobayashi Y; Aggarwal BB
    J Biol Chem; 2005 Apr; 280(17):17203-12. PubMed ID: 15710601
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Butein, a tetrahydroxychalcone, inhibits nuclear factor (NF)-kappaB and NF-kappaB-regulated gene expression through direct inhibition of IkappaBalpha kinase beta on cysteine 179 residue.
    Pandey MK; Sandur SK; Sung B; Sethi G; Kunnumakkara AB; Aggarwal BB
    J Biol Chem; 2007 Jun; 282(24):17340-50. PubMed ID: 17439942
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Targeting nuclear factor-kappa B activation pathway by thymoquinone: role in suppression of antiapoptotic gene products and enhancement of apoptosis.
    Sethi G; Ahn KS; Aggarwal BB
    Mol Cancer Res; 2008 Jun; 6(6):1059-70. PubMed ID: 18567808
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Cryptopleurine targets NF-κB pathway, leading to inhibition of gene products associated with cell survival, proliferation, invasion, and angiogenesis.
    Jin HR; Jin SZ; Cai XF; Li D; Wu X; Nan JX; Lee JJ; Jin X
    PLoS One; 2012; 7(6):e40355. PubMed ID: 22768286
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Ursolic acid inhibits nuclear factor-kappaB activation induced by carcinogenic agents through suppression of IkappaBalpha kinase and p65 phosphorylation: correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1.
    Shishodia S; Majumdar S; Banerjee S; Aggarwal BB
    Cancer Res; 2003 Aug; 63(15):4375-83. PubMed ID: 12907607
    [TBL] [Abstract][Full Text] [Related]  

  • 11. A synthetic triterpenoid, CDDO-Me, inhibits IkappaBalpha kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor kappaB-regulated gene products in human leukemic cells.
    Shishodia S; Sethi G; Konopleva M; Andreeff M; Aggarwal BB
    Clin Cancer Res; 2006 Mar; 12(6):1828-38. PubMed ID: 16551868
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Zerumbone abolishes NF-kappaB and IkappaBalpha kinase activation leading to suppression of antiapoptotic and metastatic gene expression, upregulation of apoptosis, and downregulation of invasion.
    Takada Y; Murakami A; Aggarwal BB
    Oncogene; 2005 Oct; 24(46):6957-69. PubMed ID: 16007145
    [TBL] [Abstract][Full Text] [Related]  

  • 13. N-(4-hydroxyphenyl)retinamide inhibits invasion, suppresses osteoclastogenesis, and potentiates apoptosis through down-regulation of I(kappa)B(alpha) kinase and nuclear factor-kappaB-regulated gene products.
    Shishodia S; Gutierrez AM; Lotan R; Aggarwal BB
    Cancer Res; 2005 Oct; 65(20):9555-65. PubMed ID: 16230421
    [TBL] [Abstract][Full Text] [Related]  

  • 14. A novel pentamethoxyflavone down-regulates tumor cell survival and proliferative and angiogenic gene products through inhibition of IκB kinase activation and sensitizes tumor cells to apoptosis by cytokines and chemotherapeutic agents.
    Phromnoi K; Reuter S; Sung B; Prasad S; Kannappan R; Yadav VR; Chanmahasathien W; Limtrakul P; Aggarwal BB
    Mol Pharmacol; 2011 Feb; 79(2):279-89. PubMed ID: 20930110
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Suppression of constitutive and tumor necrosis factor alpha-induced nuclear factor (NF)-kappaB activation and induction of apoptosis by apigenin in human prostate carcinoma PC-3 cells: correlation with down-regulation of NF-kappaB-responsive genes.
    Shukla S; Gupta S
    Clin Cancer Res; 2004 May; 10(9):3169-78. PubMed ID: 15131058
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) suppresses NF-kappaB activation and NF-kappaB-regulated gene products through modulation of p65 and IkappaBalpha kinase activation, leading to potentiation of apoptosis induced by cytokine and chemotherapeutic agents.
    Sandur SK; Ichikawa H; Sethi G; Ahn KS; Aggarwal BB
    J Biol Chem; 2006 Jun; 281(25):17023-17033. PubMed ID: 16624823
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-kappaB-regulated gene products and TAK1-mediated NF-kappaB activation.
    Sethi G; Ahn KS; Pandey MK; Aggarwal BB
    Blood; 2007 Apr; 109(7):2727-35. PubMed ID: 17110449
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Modification of cysteine 179 of IkappaBalpha kinase by nimbolide leads to down-regulation of NF-kappaB-regulated cell survival and proliferative proteins and sensitization of tumor cells to chemotherapeutic agents.
    Gupta SC; Prasad S; Reuter S; Kannappan R; Yadav VR; Ravindran J; Hema PS; Chaturvedi MM; Nair M; Aggarwal BB
    J Biol Chem; 2010 Nov; 285(46):35406-17. PubMed ID: 20829362
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Protein farnesyltransferase inhibitor (SCH 66336) abolishes NF-kappaB activation induced by various carcinogens and inflammatory stimuli leading to suppression of NF-kappaB-regulated gene expression and up-regulation of apoptosis.
    Takada Y; Khuri FR; Aggarwal BB
    J Biol Chem; 2004 Jun; 279(25):26287-99. PubMed ID: 15090542
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Coronarin D, a labdane diterpene, inhibits both constitutive and inducible nuclear factor-kappa B pathway activation, leading to potentiation of apoptosis, inhibition of invasion, and suppression of osteoclastogenesis.
    Kunnumakkara AB; Ichikawa H; Anand P; Mohankumar CJ; Hema PS; Nair MS; Aggarwal BB
    Mol Cancer Ther; 2008 Oct; 7(10):3306-17. PubMed ID: 18852134
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 18.