BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

187 related articles for article (PubMed ID: 22067061)

  • 1. Coordinated increase of γ-secretase reaction products in the plasma of some female Japanese sporadic Alzheimer's disease patients: quantitative analysis of p3-Alcα with a new ELISA system.
    Konno T; Hata S; Hamada Y; Horikoshi-Sakuraba Y; Nakaya T; Saito Y; Yamamoto T; Yamamoto T; Maeda M; Ikeuchi T; Gandy S; Akatsu H; Suzuki T;
    Mol Neurodegener; 2011 Nov; 6():76. PubMed ID: 22067061
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Multiple γ-secretase product peptides are coordinately increased in concentration in the cerebrospinal fluid of a subpopulation of sporadic Alzheimer's disease subjects.
    Hata S; Taniguchi M; Piao Y; Ikeuchi T; Fagan AM; Holtzman DM; Bateman R; Sohrabi HR; Martins RN; Gandy S; Urakami K; Suzuki T;
    Mol Neurodegener; 2012 Apr; 7():16. PubMed ID: 22534039
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Increased levels of plasma p3-alcα35, a major fragment of Alcadeinα by γ-secretase cleavage, in Alzheimer's disease.
    Omori C; Kaneko M; Nakajima E; Akatsu H; Waragai M; Maeda M; Morishima-Kawashima M; Saito Y; Nakaya T; Taru H; Yamamoto T; Asada T; Hata S; Suzuki T;
    J Alzheimers Dis; 2014; 39(4):861-70. PubMed ID: 24305499
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Alternative processing of γ-secretase substrates in common forms of mild cognitive impairment and Alzheimer's disease: evidence for γ-secretase dysfunction.
    Hata S; Fujishige S; Araki Y; Taniguchi M; Urakami K; Peskind E; Akatsu H; Araseki M; Yamamoto K; Martins RN; Maeda M; Nishimura M; Levey A; Chung KA; Montine T; Leverenz J; Fagan A; Goate A; Bateman R; Holtzman DM; Yamamoto T; Nakaya T; Gandy S; Suzuki T
    Ann Neurol; 2011 Jun; 69(6):1026-31. PubMed ID: 21681798
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Potential utility of soluble p3-alcadein α plasma levels as a biomarker for sporadic Alzheimer's disease.
    Kamogawa K; Kohara K; Tabara Y; Takita R; Miki T; Konno T; Hata S; Suzuki T
    J Alzheimers Dis; 2012; 31(2):421-8. PubMed ID: 22571980
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Conformational Models of APP Processing by Gamma Secretase Based on Analysis of Pathogenic Mutations.
    Kim M; Bezprozvanny I
    Int J Mol Sci; 2021 Dec; 22(24):. PubMed ID: 34948396
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Presenilin Is Essential for ApoE Secretion, a Novel Role of Presenilin Involved in Alzheimer's Disease Pathogenesis.
    Islam S; Sun Y; Gao Y; Nakamura T; Noorani AA; Li T; Wong PC; Kimura N; Matsubara E; Kasuga K; Ikeuchi T; Tomita T; Zou K; Michikawa M
    J Neurosci; 2022 Feb; 42(8):1574-1586. PubMed ID: 34987110
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Alcadein cleavages by amyloid beta-precursor protein (APP) alpha- and gamma-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma-secretase dysfunction.
    Hata S; Fujishige S; Araki Y; Kato N; Araseki M; Nishimura M; Hartmann D; Saftig P; Fahrenholz F; Taniguchi M; Urakami K; Akatsu H; Martins RN; Yamamoto K; Maeda M; Yamamoto T; Nakaya T; Gandy S; Suzuki T
    J Biol Chem; 2009 Dec; 284(52):36024-36033. PubMed ID: 19864413
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Mechanism of intramembrane cleavage of alcadeins by γ-secretase.
    Piao Y; Kimura A; Urano S; Saito Y; Taru H; Yamamoto T; Hata S; Suzuki T
    PLoS One; 2013; 8(4):e62431. PubMed ID: 23658629
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Cytoplasmic fragment of Alcadein α generated by regulated intramembrane proteolysis enhances amyloid β-protein precursor (APP) transport into the late secretory pathway and facilitates APP cleavage.
    Takei N; Sobu Y; Kimura A; Urano S; Piao Y; Araki Y; Taru H; Yamamoto T; Hata S; Nakaya T; Suzuki T
    J Biol Chem; 2015 Jan; 290(2):987-95. PubMed ID: 25406318
    [TBL] [Abstract][Full Text] [Related]  

  • 11. [Molecular Pathogenesis of Sporadic Alzheimer's Disease (AD) and Pharmaceutical Research to Develop a Biomarker for AD Diagnosis].
    Hata S
    Yakugaku Zasshi; 2015; 135(9):1023-7. PubMed ID: 26329547
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Amyloid-beta protein clearance and degradation (ABCD) pathways and their role in Alzheimer's disease.
    Baranello RJ; Bharani KL; Padmaraju V; Chopra N; Lahiri DK; Greig NH; Pappolla MA; Sambamurti K
    Curr Alzheimer Res; 2015; 12(1):32-46. PubMed ID: 25523424
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Major carboxyl terminal fragments generated by γ-secretase processing of the Alzheimer amyloid precursor are 50 and 51 amino acids long.
    Pinnix I; Ghiso JA; Pappolla MA; Sambamurti K
    Am J Geriatr Psychiatry; 2013 May; 21(5):474-83. PubMed ID: 23570890
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Hydrophilic loop 1 of Presenilin-1 and the APP GxxxG transmembrane motif regulate γ-secretase function in generating Alzheimer-causing Aβ peptides.
    Liu L; Lauro BM; Wolfe MS; Selkoe DJ
    J Biol Chem; 2021; 296():100393. PubMed ID: 33571524
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Measurement of alpha- and beta-secretase cleaved amyloid precursor protein in cerebrospinal fluid from Alzheimer patients.
    Olsson A; Höglund K; Sjögren M; Andreasen N; Minthon L; Lannfelt L; Buerger K; Möller HJ; Hampel H; Davidsson P; Blennow K
    Exp Neurol; 2003 Sep; 183(1):74-80. PubMed ID: 12957490
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The Alzheimer's Disease γ-Secretase Generates Higher 42:40 Ratios for β-Amyloid Than for p3 Peptides.
    Siegel G; Gerber H; Koch P; Bruestle O; Fraering PC; Rajendran L
    Cell Rep; 2017 Jun; 19(10):1967-1976. PubMed ID: 28591569
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by γ-Secretase and Amyloid-β Peptide Production.
    Gerber H; Wu F; Dimitrov M; Garcia Osuna GM; Fraering PC
    J Biol Chem; 2017 Mar; 292(9):3751-3767. PubMed ID: 28096459
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Amyloidogenic processing of amyloid β protein precursor (APP) is enhanced in the brains of alcadein α-deficient mice.
    Gotoh N; Saito Y; Hata S; Saito H; Ojima D; Murayama C; Shigeta M; Abe T; Konno D; Matsuzaki F; Suzuki T; Yamamoto T
    J Biol Chem; 2020 Jul; 295(28):9650-9662. PubMed ID: 32467230
    [TBL] [Abstract][Full Text] [Related]  

  • 19. γ-Secretase structure and activity are modified by alterations in its membrane localization and ambient environment.
    Suzuki T; Sobu Y; Hata S
    J Biochem; 2022 Mar; 171(3):253-256. PubMed ID: 34865063
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Proteolytic processing of the Alzheimer's disease amyloid precursor protein in brain and platelets.
    Evin G; Zhu A; Holsinger RM; Masters CL; Li QX
    J Neurosci Res; 2003 Nov; 74(3):386-92. PubMed ID: 14598315
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.