BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

165 related articles for article (PubMed ID: 2206778)

  • 1. Preferential selection during therapy in vivo by edatrexate compared to methotrexate of resistant L1210 cell variants with decreased folylpolyglutamate synthetase activity.
    Rumberger BG; Schmid FA; Otter GM; Sirotnak FM
    Cancer Commun; 1990; 2(9):305-10. PubMed ID: 2206778
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Differing specificities for 4-aminofolate analogues of folylpolyglutamyl synthetase from tumors and proliferative intestinal epithelium of the mouse with significance for selective antitumor action.
    Rumberger BG; Barrueco JR; Sirotnak FM
    Cancer Res; 1990 Aug; 50(15):4639-43. PubMed ID: 2369741
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The mechanism of transport of the multitargeted antifolate (MTA) and its cross-resistance pattern in cells with markedly impaired transport of methotrexate.
    Zhao R; Babani S; Gao F; Liu L; Goldman ID
    Clin Cancer Res; 2000 Sep; 6(9):3687-95. PubMed ID: 10999762
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Relative frequency and kinetic properties of transport-defective phenotypes among methotrexate-resistant L1210 clonal cell lines derived in vivo.
    Sirotnak FM; Moccio DM; Kelleher LE; Goutas LJ
    Cancer Res; 1981 Nov; 41(11 Pt 1):4447-52. PubMed ID: 7306968
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Folylpolyglutamate synthetase expression in antifolate-sensitive and -resistant human cell lines.
    McGuire JJ; Russell CA
    Oncol Res; 1998; 10(4):193-200. PubMed ID: 9778690
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis and biologic activity of new side-chain-altered methotrexate and aminopterin analogs with dual inhibitory action against dihydrofolate reductase and folylpolyglutamate synthetase.
    Rosowsky A; Moran RG; Freisheim JH; Bader H; Forsch RA; Solan VC
    NCI Monogr; 1987; (5):145-52. PubMed ID: 3431589
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Methotrexate analogues. 34. Replacement of the glutamate moiety in methotrexate and aminopterin by long-chain 2-aminoalkanedioic acids.
    Rosowsky A; Bader H; Kohler W; Freisheim JH; Moran RG
    J Med Chem; 1988 Jul; 31(7):1338-44. PubMed ID: 2898531
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Different antifolate-resistant L1210 cell variants with either increased or decreased folylpolyglutamate synthetase gene expression at the level of mRNA transcription.
    Roy K; Mitsugi K; Sirlin S; Shane B; Sirotnak FM
    J Biol Chem; 1995 Nov; 270(45):26918-22. PubMed ID: 7592937
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Posttranscriptionally mediated decreases in folylpolyglutamate synthetase gene expression in some folate analogue-resistant variants of the L1210 cell. Evidence for an altered cognate mRNA in the variants affecting the rate of de novo synthesis of the enzyme.
    Roy K; Egan MG; Sirlin S; Sirotnak FM
    J Biol Chem; 1997 Mar; 272(11):6903-8. PubMed ID: 9054377
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Carrier- and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular-structure and biological activity.
    Westerhof GR; Schornagel JH; Kathmann I; Jackman AL; Rosowsky A; Forsch RA; Hynes JB; Boyle FT; Peters GJ; Pinedo HM
    Mol Pharmacol; 1995 Sep; 48(3):459-71. PubMed ID: 7565626
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Similar differential for total polyglutamylation and cytotoxicity among various folate analogues in human and murine tumor cells in vitro.
    Samuels LL; Moccio DM; Sirotnak FM
    Cancer Res; 1985 Apr; 45(4):1488-95. PubMed ID: 3978616
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Loss of folylpoly-gamma-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines.
    Liani E; Rothem L; Bunni MA; Smith CA; Jansen G; Assaraf YG
    Int J Cancer; 2003 Feb; 103(5):587-99. PubMed ID: 12494465
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Novel 6,5-fused ring heterocyclic antifolates: biochemical and biological characterization.
    McGuire JJ; Bergoltz VV; Heitzman KJ; Haile WH; Russell CA; Bolanowska WE; Kotake Y; Haneda T; Nomura H
    Cancer Res; 1994 May; 54(10):2673-9. PubMed ID: 8168096
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Patterns of cross-resistance to the antifolate drugs trimetrexate, metoprine, homofolate, and CB3717 in human lymphoma and osteosarcoma cells resistant to methotrexate.
    Diddens H; Niethammer D; Jackson RC
    Cancer Res; 1983 Nov; 43(11):5286-92. PubMed ID: 6225514
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Methotrexate analogues. 26. Inhibition of dihydrofolate reductase and folylpolyglutamate synthetase activity and in vitro tumor cell growth by methotrexate and aminopterin analogues containing a basic amino acid side chain.
    Rosowsky A; Freisheim JH; Moran RG; Solan VC; Bader H; Wright JE; Radike-Smith M
    J Med Chem; 1986 May; 29(5):655-60. PubMed ID: 2871191
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Impact of polyglutamation on sensitivity to raltitrexed and methotrexate in relation to drug-induced inhibition of de novo thymidylate and purine biosynthesis in CCRF-CEM cell lines.
    Barnes MJ; Estlin EJ; Taylor GA; Aherne GW; Hardcastle A; McGuire JJ; Calvete JA; Lunec J; Pearson AD; Newell DR
    Clin Cancer Res; 1999 Sep; 5(9):2548-58. PubMed ID: 10499632
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Biochemical and growth inhibition studies of methotrexate and aminopterin analogues containing a tetrazole ring in place of the gamma-carboxyl group.
    McGuire JJ; Russell CA; Bolanowska WE; Freitag CM; Jones CS; Kalman TI
    Cancer Res; 1990 Mar; 50(6):1726-31. PubMed ID: 2306727
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A new analogue of 10-deazaaminopterin with markedly enhanced curative effects against human tumor xenografts in mice.
    Sirotnak FM; DeGraw JI; Colwell WT; Piper JR
    Cancer Chemother Pharmacol; 1998; 42(4):313-8. PubMed ID: 9744777
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Sensitivity to 5,10-dideazatetrahydrofolate is fully conserved in a murine leukemia cell line highly resistant to methotrexate due to impaired transport mediated by the reduced folate carrier.
    Zhao R; Gao F; Babani S; Goldman ID
    Clin Cancer Res; 2000 Aug; 6(8):3304-11. PubMed ID: 10955817
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Methotrexate analogues. 33. N delta-acyl-N alpha-(4-amino-4-deoxypteroyl)-L-ornithine derivatives: synthesis and in vitro antitumor activity.
    Rosowsky A; Bader H; Cucchi CA; Moran RG; Kohler W; Freisheim JH
    J Med Chem; 1988 Jul; 31(7):1332-7. PubMed ID: 3385730
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.