These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

271 related articles for article (PubMed ID: 22074918)

  • 21. Dominant negative effect of the loss-of-function γ-secretase mutants on the wild-type enzyme through heterooligomerization.
    Zhou R; Yang G; Shi Y
    Proc Natl Acad Sci U S A; 2017 Nov; 114(48):12731-12736. PubMed ID: 29078389
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities.
    Lai MT; Chen E; Crouthamel MC; DiMuzio-Mower J; Xu M; Huang Q; Price E; Register RB; Shi XP; Donoviel DB; Bernstein A; Hazuda D; Gardell SJ; Li YM
    J Biol Chem; 2003 Jun; 278(25):22475-81. PubMed ID: 12684521
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes.
    Shirotani K; Tomioka M; Kremmer E; Haass C; Steiner H
    Neurobiol Dis; 2007 Jul; 27(1):102-7. PubMed ID: 17560791
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Flexible and Accurate Substrate Processing with Distinct Presenilin/γ-Secretases in Human Cortical Neurons.
    Watanabe H; Imaizumi K; Cai T; Zhou Z; Tomita T; Okano H
    eNeuro; 2021; 8(2):. PubMed ID: 33608391
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Interactome analyses of mature γ-secretase complexes reveal distinct molecular environments of presenilin (PS) paralogs and preferential binding of signal peptide peptidase to PS2.
    Jeon AH; Böhm C; Chen F; Huo H; Ruan X; Ren CH; Ho K; Qamar S; Mathews PM; Fraser PE; Mount HT; St George-Hyslop P; Schmitt-Ulms G
    J Biol Chem; 2013 May; 288(21):15352-66. PubMed ID: 23589300
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Mutation analysis of the presenilin 1 N-terminal domain reveals a broad spectrum of gamma-secretase activity toward amyloid precursor protein and other substrates.
    Gong P; Vetrivel KS; Nguyen PD; Meckler X; Cheng H; Kounnas MZ; Wagner SL; Parent AT; Thinakaran G
    J Biol Chem; 2010 Dec; 285(49):38042-52. PubMed ID: 20921220
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Characterization of the reconstituted gamma-secretase complex from Sf9 cells co-expressing presenilin 1, nicastrin [correction of nacastrin], aph-1a, and pen-2.
    Zhang L; Lee J; Song L; Sun X; Shen J; Terracina G; Parker EM
    Biochemistry; 2005 Mar; 44(11):4450-7. PubMed ID: 15766275
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Advanced Yeast Models of Familial Alzheimer Disease Expressing FAD-Linked Presenilin to Screen Mutations and γ-Secretase Modulators.
    Futai E
    Methods Mol Biol; 2019; 2049():403-417. PubMed ID: 31602624
    [TBL] [Abstract][Full Text] [Related]  

  • 29. APH1, PEN2, and Nicastrin increase Abeta levels and gamma-secretase activity.
    Marlow L; Canet RM; Haugabook SJ; Hardy JA; Lahiri DK; Sambamurti K
    Biochem Biophys Res Commun; 2003 Jun; 305(3):502-9. PubMed ID: 12763021
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Alzheimer's disease-linked mutations in presenilin-1 result in a drastic loss of activity in purified γ-secretase complexes.
    Cacquevel M; Aeschbach L; Houacine J; Fraering PC
    PLoS One; 2012; 7(4):e35133. PubMed ID: 22529981
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Presenilin Is Essential for ApoE Secretion, a Novel Role of Presenilin Involved in Alzheimer's Disease Pathogenesis.
    Islam S; Sun Y; Gao Y; Nakamura T; Noorani AA; Li T; Wong PC; Kimura N; Matsubara E; Kasuga K; Ikeuchi T; Tomita T; Zou K; Michikawa M
    J Neurosci; 2022 Feb; 42(8):1574-1586. PubMed ID: 34987110
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1.
    Shirotani K; Edbauer D; Kostka M; Steiner H; Haass C
    J Neurochem; 2004 Jun; 89(6):1520-7. PubMed ID: 15189355
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Reconstitution of gamma-secretase activity.
    Edbauer D; Winkler E; Regula JT; Pesold B; Steiner H; Haass C
    Nat Cell Biol; 2003 May; 5(5):486-8. PubMed ID: 12679784
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease.
    Steiner H; Capell A; Leimer U; Haass C
    Eur Arch Psychiatry Clin Neurosci; 1999; 249(6):266-70. PubMed ID: 10653281
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Activation and intrinsic gamma-secretase activity of presenilin 1.
    Ahn K; Shelton CC; Tian Y; Zhang X; Gilchrist ML; Sisodia SS; Li YM
    Proc Natl Acad Sci U S A; 2010 Dec; 107(50):21435-40. PubMed ID: 21115843
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Signature amyloid β profiles are produced by different γ-secretase complexes.
    Acx H; Chávez-Gutiérrez L; Serneels L; Lismont S; Benurwar M; Elad N; De Strooper B
    J Biol Chem; 2014 Feb; 289(7):4346-55. PubMed ID: 24338474
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Presenilin transmembrane domain 8 conserved AXXXAXXXG motifs are required for the activity of the γ-secretase complex.
    Marinangeli C; Tasiaux B; Opsomer R; Hage S; Sodero AO; Dewachter I; Octave JN; Smith SO; Constantinescu SN; Kienlen-Campard P
    J Biol Chem; 2015 Mar; 290(11):7169-84. PubMed ID: 25614624
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Identification of gamma-secretase inhibitor potency determinants on presenilin.
    Zhao B; Yu M; Neitzel M; Marugg J; Jagodzinski J; Lee M; Hu K; Schenk D; Yednock T; Basi G
    J Biol Chem; 2008 Feb; 283(5):2927-38. PubMed ID: 18032377
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Pen2 and presenilin-1 modulate the dynamic equilibrium of presenilin-1 and presenilin-2 gamma-secretase complexes.
    Placanica L; Tarassishin L; Yang G; Peethumnongsin E; Kim SH; Zheng H; Sisodia SS; Li YM
    J Biol Chem; 2009 Jan; 284(5):2967-2977. PubMed ID: 19036728
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components.
    Zhang YW; Luo WJ; Wang H; Lin P; Vetrivel KS; Liao F; Li F; Wong PC; Farquhar MG; Thinakaran G; Xu H
    J Biol Chem; 2005 Apr; 280(17):17020-6. PubMed ID: 15711015
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 14.