These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

125 related articles for article (PubMed ID: 22074985)

  • 1. 3,5-Disubstituted-thiazolidine-2,4-dione analogs as anticancer agents: design, synthesis and biological characterization.
    Liu K; Rao W; Parikh H; Li Q; Guo TL; Grant S; Kellogg GE; Zhang S
    Eur J Med Chem; 2012 Jan; 47(1):125-37. PubMed ID: 22074985
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Discovery of 3-(2-aminoethyl)-5-(3-phenyl-propylidene)-thiazolidine-2,4-dione as a dual inhibitor of the Raf/MEK/ERK and the PI3K/Akt signaling pathways.
    Li Q; Wu J; Zheng H; Liu K; Guo TL; Liu Y; Eblen ST; Grant S; Zhang S
    Bioorg Med Chem Lett; 2010 Aug; 20(15):4526-30. PubMed ID: 20580230
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Role of RAF/MEK/ERK pathway, p-STAT-3 and Mcl-1 in sorafenib activity in human pancreatic cancer cell lines.
    Ulivi P; Arienti C; Amadori D; Fabbri F; Carloni S; Tesei A; Vannini I; Silvestrini R; Zoli W
    J Cell Physiol; 2009 Jul; 220(1):214-21. PubMed ID: 19288493
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Biological characterization of 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) as a selective sphingosine kinase-2 inhibitor and anticancer agent.
    Liu K; Guo TL; Hait NC; Allegood J; Parikh HI; Xu W; Kellogg GE; Grant S; Spiegel S; Zhang S
    PLoS One; 2013; 8(2):e56471. PubMed ID: 23437140
    [TBL] [Abstract][Full Text] [Related]  

  • 5. beta-Sitosterol induces G2/M arrest, endoreduplication, and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways.
    Moon DO; Kim MO; Choi YH; Kim GY
    Cancer Lett; 2008 Jun; 264(2):181-91. PubMed ID: 18314257
    [TBL] [Abstract][Full Text] [Related]  

  • 6. WJD008, a dual phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin inhibitor, prevents PI3K signaling and inhibits the proliferation of transformed cells with oncogenic PI3K mutant.
    Li T; Wang J; Wang X; Yang N; Chen SM; Tong LJ; Yang CH; Meng LH; Ding J
    J Pharmacol Exp Ther; 2010 Sep; 334(3):830-8. PubMed ID: 20522531
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Anticancer activity of novel hybrid molecules containing 5-benzylidene thiazolidine-2,4-dione.
    Romagnoli R; Baraldi PG; Salvador MK; Camacho ME; Balzarini J; Bermejo J; Estévez F
    Eur J Med Chem; 2013 May; 63():544-57. PubMed ID: 23537942
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Enhancement of peripheral benzodiazepine receptor ligand-induced apoptosis and cell cycle arrest of esophageal cancer cells by simultaneous inhibition of MAPK/ERK kinase.
    Sutter AP; Maaser K; Gerst B; Krahn A; Zeitz M; Scherübl H
    Biochem Pharmacol; 2004 May; 67(9):1701-10. PubMed ID: 15081869
    [TBL] [Abstract][Full Text] [Related]  

  • 9. In vivo antitumor activity of MEK and phosphatidylinositol 3-kinase inhibitors in basal-like breast cancer models.
    Hoeflich KP; O'Brien C; Boyd Z; Cavet G; Guerrero S; Jung K; Januario T; Savage H; Punnoose E; Truong T; Zhou W; Berry L; Murray L; Amler L; Belvin M; Friedman LS; Lackner MR
    Clin Cancer Res; 2009 Jul; 15(14):4649-64. PubMed ID: 19567590
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Inhibition of doxorubicin-induced autophagy in hepatocellular carcinoma Hep3B cells by sorafenib--the role of extracellular signal-regulated kinase counteraction.
    Manov I; Pollak Y; Broneshter R; Iancu TC
    FEBS J; 2011 Sep; 278(18):3494-507. PubMed ID: 21790999
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Effects of the RAF/MEK/ERK and PI3K/AKT signal transduction pathways on the abrogation of cytokine-dependence and prevention of apoptosis in hematopoietic cells.
    Shelton JG; Steelman LS; Lee JT; Knapp SL; Blalock WL; Moye PW; Franklin RA; Pohnert SC; Mirza AM; McMahon M; McCubrey JA
    Oncogene; 2003 Apr; 22(16):2478-92. PubMed ID: 12717425
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structural modifications of (Z)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione that improve selectivity for inhibiting the proliferation of melanoma cells containing active ERK signaling.
    Jung KY; Samadani R; Chauhan J; Nevels K; Yap JL; Zhang J; Worlikar S; Lanning ME; Chen L; Ensey M; Shukla S; Salmo R; Heinzl G; Gordon C; Dukes T; MacKerell AD; Shapiro P; Fletcher S
    Org Biomol Chem; 2013 Jun; 11(22):3706-32. PubMed ID: 23624850
    [TBL] [Abstract][Full Text] [Related]  

  • 13. 7-Chloro-6-piperidin-1-yl-quinoline-5,8-dione (PT-262), a novel synthetic compound induces lung carcinoma cell death associated with inhibiting ERK and CDC2 phosphorylation via a p53-independent pathway.
    Hsu TS; Chen C; Lee PT; Chiu SJ; Liu HF; Tsai CC; Chao JI
    Cancer Chemother Pharmacol; 2008 Oct; 62(5):799-808. PubMed ID: 18193228
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Indomethacin induces apoptosis in 786-O renal cell carcinoma cells by activating mitogen-activated protein kinases and AKT.
    Ou YC; Yang CR; Cheng CL; Raung SL; Hung YY; Chen CJ
    Eur J Pharmacol; 2007 Jun; 563(1-3):49-60. PubMed ID: 17341418
    [TBL] [Abstract][Full Text] [Related]  

  • 15. PI3K-FRAP/mTOR pathway is critical for hepatocyte proliferation whereas MEK/ERK supports both proliferation and survival.
    Coutant A; Rescan C; Gilot D; Loyer P; Guguen-Guillouzo C; Baffet G
    Hepatology; 2002 Nov; 36(5):1079-88. PubMed ID: 12395317
    [TBL] [Abstract][Full Text] [Related]  

  • 16. TLN-4601, a novel anticancer agent, inhibits Ras signaling post Ras prenylation and before MEK activation.
    Boufaied N; Wioland MA; Falardeau P; Gourdeau H
    Anticancer Drugs; 2010 Jun; 21(5):543-52. PubMed ID: 20220516
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Low dose leflunomide activates PI3K/Akt signalling in erythroleukemia cells and reduces apoptosis induced by anticancer agents.
    Leger DY; Liagre B; Beneytout JL
    Apoptosis; 2006 Oct; 11(10):1747-60. PubMed ID: 16927021
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Caffeine inhibits the proliferation of liver cancer cells and activates the MEK/ERK/EGFR signalling pathway.
    Okano J; Nagahara T; Matsumoto K; Murawaki Y
    Basic Clin Pharmacol Toxicol; 2008 Jun; 102(6):543-51. PubMed ID: 18346049
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Magnolol elicits activation of the extracellular signal-regulated kinase pathway by inducing p27KIP1-mediated G2/M-phase cell cycle arrest in human urinary bladder cancer 5637 cells.
    Lee SJ; Cho YH; Park K; Kim EJ; Jung KH; Park SS; Kim WJ; Moon SK
    Biochem Pharmacol; 2008 Jun; 75(12):2289-300. PubMed ID: 18468578
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Design, synthesis, and evaluation of 3,5-disubstituted 7-azaindoles as Trk inhibitors with anticancer and antiangiogenic activities.
    Hong S; Kim J; Seo JH; Jung KH; Hong SS; Hong S
    J Med Chem; 2012 Jun; 55(11):5337-49. PubMed ID: 22575050
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.