BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

1324 related articles for article (PubMed ID: 22076378)

  • 1. Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase.
    Du J; Zhou Y; Su X; Yu JJ; Khan S; Jiang H; Kim J; Woo J; Kim JH; Choi BH; He B; Chen W; Zhang S; Cerione RA; Auwerx J; Hao Q; Lin H
    Science; 2011 Nov; 334(6057):806-9. PubMed ID: 22076378
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structural insights into the molecular mechanism underlying Sirt5-catalyzed desuccinylation of histone peptides.
    Hang T; Chen W; Wu M; Zhan L; Wang C; Jia N; Zhang X; Zang J
    Biochem J; 2019 Jan; 476(2):211-223. PubMed ID: 30523058
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Quantitative Analysis of the Sirt5-Regulated Lysine Succinylation Proteome in Mammalian Cells.
    Chen Y
    Methods Mol Biol; 2016; 1410():23-37. PubMed ID: 26867736
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Lysine desuccinylase SIRT5 binds to cardiolipin and regulates the electron transport chain.
    Zhang Y; Bharathi SS; Rardin MJ; Lu J; Maringer KV; Sims-Lucas S; Prochownik EV; Gibson BW; Goetzman ES
    J Biol Chem; 2017 Jun; 292(24):10239-10249. PubMed ID: 28458255
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The bicyclic intermediate structure provides insights into the desuccinylation mechanism of human sirtuin 5 (SIRT5).
    Zhou Y; Zhang H; He B; Du J; Lin H; Cerione RA; Hao Q
    J Biol Chem; 2012 Aug; 287(34):28307-14. PubMed ID: 22767592
    [TBL] [Abstract][Full Text] [Related]  

  • 6. LC-MS/MS-based quantitative study of the acyl group- and site-selectivity of human sirtuins to acylated nucleosomes.
    Tanabe K; Liu J; Kato D; Kurumizaka H; Yamatsugu K; Kanai M; Kawashima SA
    Sci Rep; 2018 Feb; 8(1):2656. PubMed ID: 29422688
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Overexpression of SIRT5 confirms its involvement in deacetylation and activation of carbamoyl phosphate synthetase 1.
    Ogura M; Nakamura Y; Tanaka D; Zhuang X; Fujita Y; Obara A; Hamasaki A; Hosokawa M; Inagaki N
    Biochem Biophys Res Commun; 2010 Feb; 393(1):73-8. PubMed ID: 20097174
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Chemical probing of the human sirtuin 5 active site reveals its substrate acyl specificity and peptide-based inhibitors.
    Roessler C; Nowak T; Pannek M; Gertz M; Nguyen GT; Scharfe M; Born I; Sippl W; Steegborn C; Schutkowski M
    Angew Chem Int Ed Engl; 2014 Sep; 53(40):10728-32. PubMed ID: 25111069
    [TBL] [Abstract][Full Text] [Related]  

  • 9. SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle.
    Nakagawa T; Lomb DJ; Haigis MC; Guarente L
    Cell; 2009 May; 137(3):560-70. PubMed ID: 19410549
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Lysine glutarylation is a protein posttranslational modification regulated by SIRT5.
    Tan M; Peng C; Anderson KA; Chhoy P; Xie Z; Dai L; Park J; Chen Y; Huang H; Zhang Y; Ro J; Wagner GR; Green MF; Madsen AS; Schmiesing J; Peterson BS; Xu G; Ilkayeva OR; Muehlbauer MJ; Braulke T; Mühlhausen C; Backos DS; Olsen CA; McGuire PJ; Pletcher SD; Lombard DB; Hirschey MD; Zhao Y
    Cell Metab; 2014 Apr; 19(4):605-17. PubMed ID: 24703693
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The ɛ-Amino Group of Protein Lysine Residues Is Highly Susceptible to Nonenzymatic Acylation by Several Physiological Acyl-CoA Thioesters.
    Simic Z; Weiwad M; Schierhorn A; Steegborn C; Schutkowski M
    Chembiochem; 2015 Nov; 16(16):2337-47. PubMed ID: 26382620
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Characterization of the cardiac succinylome and its role in ischemia-reperfusion injury.
    Boylston JA; Sun J; Chen Y; Gucek M; Sack MN; Murphy E
    J Mol Cell Cardiol; 2015 Nov; 88():73-81. PubMed ID: 26388266
    [TBL] [Abstract][Full Text] [Related]  

  • 13. SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.
    Park J; Chen Y; Tishkoff DX; Peng C; Tan M; Dai L; Xie Z; Zhang Y; Zwaans BM; Skinner ME; Lombard DB; Zhao Y
    Mol Cell; 2013 Jun; 50(6):919-30. PubMed ID: 23806337
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Regulation of urea cycle by reversible high-stoichiometry lysine succinylation.
    Zhang R; Fang J; Xie X; Carrico C; Meyer JG; Wei L; Bons J; Rose J; Riley R; Kwok R; Ashok Kumaar PV; Zhang Y; He W; Nishida Y; Liu X; Locasale JW; Schilling B; Verdin E
    Nat Metab; 2024 Mar; 6(3):550-566. PubMed ID: 38448615
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Sirt5 deacylation activities show differential sensitivities to nicotinamide inhibition.
    Fischer F; Gertz M; Suenkel B; Lakshminarasimhan M; Schutkowski M; Steegborn C
    PLoS One; 2012; 7(9):e45098. PubMed ID: 23028781
    [TBL] [Abstract][Full Text] [Related]  

  • 16. An optimized desuccinylase activity assay reveals a difference in desuccinylation activity between proliferative and differentiated cells.
    Yuan T; Keijer J; Guo AH; Lombard DB; de Boer VCJ
    Sci Rep; 2020 Oct; 10(1):17030. PubMed ID: 33046741
    [TBL] [Abstract][Full Text] [Related]  

  • 17. SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks.
    Rardin MJ; He W; Nishida Y; Newman JC; Carrico C; Danielson SR; Guo A; Gut P; Sahu AK; Li B; Uppala R; Fitch M; Riiff T; Zhu L; Zhou J; Mulhern D; Stevens RD; Ilkayeva OR; Newgard CB; Jacobson MP; Hellerstein M; Goetzman ES; Gibson BW; Verdin E
    Cell Metab; 2013 Dec; 18(6):920-33. PubMed ID: 24315375
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function.
    Sadhukhan S; Liu X; Ryu D; Nelson OD; Stupinski JA; Li Z; Chen W; Zhang S; Weiss RS; Locasale JW; Auwerx J; Lin H
    Proc Natl Acad Sci U S A; 2016 Apr; 113(16):4320-5. PubMed ID: 27051063
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Exogenous nicotinamide adenine dinucleotide administration alleviates ischemia/reperfusion-induced oxidative injury in isolated rat hearts via Sirt5-SDH-succinate pathway.
    Liu L; Wang Q; Zhao B; Wu Q; Wang P
    Eur J Pharmacol; 2019 Sep; 858():172520. PubMed ID: 31278893
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Ablation of
    Hershberger KA; Abraham DM; Liu J; Locasale JW; Grimsrud PA; Hirschey MD
    J Biol Chem; 2018 Jul; 293(27):10630-10645. PubMed ID: 29769314
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 67.