These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

165 related articles for article (PubMed ID: 22076419)

  • 1. A novel model and molecular therapy for Z alpha-1 antitrypsin deficiency.
    McNab GL; Dafforn TR; Wood A; Sapey E; Stockley RA
    Mamm Genome; 2012 Apr; 23(3-4):241-9. PubMed ID: 22076419
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The molecular species responsible for α
    Ronzoni R; Heyer-Chauhan N; Fra A; Pearce AC; Rüdiger M; Miranda E; Irving JA; Lomas DA
    FEBS J; 2021 Apr; 288(7):2222-2237. PubMed ID: 33058391
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Modification of gene expression and increase in alpha1-antitrypsin (alpha1-AT) secretion after homologous recombination in alpha1-AT-deficient monocytes.
    McNab GL; Ahmad A; Mistry D; Stockley RA
    Hum Gene Ther; 2007 Nov; 18(11):1171-7. PubMed ID: 17937578
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The role of bronchial epithelial cells in the pathogenesis of COPD in Z-alpha-1 antitrypsin deficiency.
    Pini L; Tiberio L; Venkatesan N; Bezzi M; Corda L; Luisetti M; Ferrarotti I; Malerba M; Lomas DA; Janciauskiene S; Vizzardi E; Modina D; Schiaffonati L; Tantucci C
    Respir Res; 2014 Sep; 15(1):112. PubMed ID: 25218041
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Therapeutic targeting of misfolding and conformational change in α1-antitrypsin deficiency.
    Nyon MP; Gooptu B
    Future Med Chem; 2014 Jun; 6(9):1047-65. PubMed ID: 25068987
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Activation of endoplasmic reticulum-specific stress responses associated with the conformational disease Z alpha 1-antitrypsin deficiency.
    Lawless MW; Greene CM; Mulgrew A; Taggart CC; O'Neill SJ; McElvaney NG
    J Immunol; 2004 May; 172(9):5722-6. PubMed ID: 15100318
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A transgenic zebrafish model of hepatocyte function in human Z α1-antitrypsin deficiency.
    Yip E; Giousoh A; Fung C; Wilding B; Prakash MD; Williams C; Verkade H; Bryson-Richardson RJ; Bird PI
    Biol Chem; 2019 Nov; 400(12):1603-1616. PubMed ID: 31091192
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Fluphenazine reduces proteotoxicity in C. elegans and mammalian models of alpha-1-antitrypsin deficiency.
    Li J; Pak SC; O'Reilly LP; Benson JA; Wang Y; Hidvegi T; Hale P; Dippold C; Ewing M; Silverman GA; Perlmutter DH
    PLoS One; 2014; 9(1):e87260. PubMed ID: 24498058
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Small molecules block the polymerization of Z alpha1-antitrypsin and increase the clearance of intracellular aggregates.
    Mallya M; Phillips RL; Saldanha SA; Gooptu B; Brown SC; Termine DJ; Shirvani AM; Wu Y; Sifers RN; Abagyan R; Lomas DA
    J Med Chem; 2007 Nov; 50(22):5357-63. PubMed ID: 17918823
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discovery of an inhibitor of Z-alpha1 antitrypsin polymerization.
    Berthelier V; Harris JB; Estenson KN; Baudry J
    PLoS One; 2015; 10(5):e0126256. PubMed ID: 25961288
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Deficiency Mutations of Alpha-1 Antitrypsin. Effects on Folding, Function, and Polymerization.
    Haq I; Irving JA; Saleh AD; Dron L; Regan-Mochrie GL; Motamedi-Shad N; Hurst JR; Gooptu B; Lomas DA
    Am J Respir Cell Mol Biol; 2016 Jan; 54(1):71-80. PubMed ID: 26091018
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The pathological Trento variant of alpha-1-antitrypsin (E75V) shows nonclassical behaviour during polymerization.
    Miranda E; Ferrarotti I; Berardelli R; Laffranchi M; Cerea M; Gangemi F; Haq I; Ottaviani S; Lomas DA; Irving JA; Fra A
    FEBS J; 2017 Jul; 284(13):2110-2126. PubMed ID: 28504839
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Intrahepatic heteropolymerization of M and Z alpha-1-antitrypsin.
    Laffranchi M; Elliston EL; Miranda E; Perez J; Ronzoni R; Jagger AM; Heyer-Chauhan N; Brantly ML; Fra A; Lomas DA; Irving JA
    JCI Insight; 2020 Jul; 5(14):. PubMed ID: 32699193
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Practical genetics: alpha-1-antitrypsin deficiency and the serpinopathies.
    Crowther DC; Belorgey D; Miranda E; Kinghorn KJ; Sharp LK; Lomas DA
    Eur J Hum Genet; 2004 Mar; 12(3):167-72. PubMed ID: 14694355
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Heteropolymerization of α-1-antitrypsin mutants in cell models mimicking heterozygosity.
    Laffranchi M; Berardelli R; Ronzoni R; Lomas DA; Fra A
    Hum Mol Genet; 2018 May; 27(10):1785-1793. PubMed ID: 29538751
    [TBL] [Abstract][Full Text] [Related]  

  • 16. High-resolution ex vivo NMR spectroscopy of human Z α
    Jagger AM; Waudby CA; Irving JA; Christodoulou J; Lomas DA
    Nat Commun; 2020 Dec; 11(1):6371. PubMed ID: 33311470
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Mineralization of alpha-1-antitrypsin inclusion bodies in Mmalton alpha-1-antitrypsin deficiency.
    Callea F; Giovannoni I; Francalanci P; Boldrini R; Faa G; Medicina D; Nobili V; Desmet VJ; Ishak K; Seyama K; Bellacchio E
    Orphanet J Rare Dis; 2018 May; 13(1):79. PubMed ID: 29769092
    [TBL] [Abstract][Full Text] [Related]  

  • 18. An analog of glibenclamide selectively enhances autophagic degradation of misfolded α1-antitrypsin Z.
    Wang Y; Cobanoglu MC; Li J; Hidvegi T; Hale P; Ewing M; Chu AS; Gong Z; Muzumdar R; Pak SC; Silverman GA; Bahar I; Perlmutter DH
    PLoS One; 2019; 14(1):e0209748. PubMed ID: 30673724
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A novel monoclonal antibody to characterize pathogenic polymers in liver disease associated with alpha1-antitrypsin deficiency.
    Miranda E; Pérez J; Ekeowa UI; Hadzic N; Kalsheker N; Gooptu B; Portmann B; Belorgey D; Hill M; Chambers S; Teckman J; Alexander GJ; Marciniak SJ; Lomas DA
    Hepatology; 2010 Sep; 52(3):1078-88. PubMed ID: 20583215
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Oxidative stress contributes to liver damage in a murine model of alpha-1-antitrypsin deficiency.
    Marcus NY; Blomenkamp K; Ahmad M; Teckman JH
    Exp Biol Med (Maywood); 2012 Oct; 237(10):1163-72. PubMed ID: 23104507
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.