181 related articles for article (PubMed ID: 22076568)
1. Combination of hedgehog signaling blockage and chemotherapy leads to tumor reduction in pancreatic adenocarcinomas.
Bahra M; Kamphues C; Boas-Knoop S; Lippert S; Esendik U; Schüller U; Hartmann W; Waha A; Neuhaus P; Heppner F; Pietsch T; Koch A
Pancreas; 2012 Mar; 41(2):222-9. PubMed ID: 22076568
[TBL] [Abstract][Full Text] [Related]
2. Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers.
Feldmann G; Dhara S; Fendrich V; Bedja D; Beaty R; Mullendore M; Karikari C; Alvarez H; Iacobuzio-Donahue C; Jimeno A; Gabrielson KL; Matsui W; Maitra A
Cancer Res; 2007 Mar; 67(5):2187-96. PubMed ID: 17332349
[TBL] [Abstract][Full Text] [Related]
3. A polymeric nanoparticle encapsulated small-molecule inhibitor of Hedgehog signaling (NanoHHI) bypasses secondary mutational resistance to Smoothened antagonists.
Chenna V; Hu C; Pramanik D; Aftab BT; Karikari C; Campbell NR; Hong SM; Zhao M; Rudek MA; Khan SR; Rudin CM; Maitra A
Mol Cancer Ther; 2012 Jan; 11(1):165-73. PubMed ID: 22027695
[TBL] [Abstract][Full Text] [Related]
4. An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer.
Feldmann G; Fendrich V; McGovern K; Bedja D; Bisht S; Alvarez H; Koorstra JB; Habbe N; Karikari C; Mullendore M; Gabrielson KL; Sharma R; Matsui W; Maitra A
Mol Cancer Ther; 2008 Sep; 7(9):2725-35. PubMed ID: 18790753
[TBL] [Abstract][Full Text] [Related]
5. Hedgehog inhibitor decreases chemosensitivity to 5-fluorouracil and gemcitabine under hypoxic conditions in pancreatic cancer.
Onishi H; Morifuji Y; Kai M; Suyama K; Iwasaki H; Katano M
Cancer Sci; 2012 Jul; 103(7):1272-9. PubMed ID: 22486854
[TBL] [Abstract][Full Text] [Related]
6. Perifosine inhibits S6K1-Gli1 signaling and enhances gemcitabine-induced anti-pancreatic cancer efficiency.
Xin Y; Shen XD; Cheng L; Hong DF; Chen B
Cancer Chemother Pharmacol; 2014 Apr; 73(4):711-9. PubMed ID: 24519751
[TBL] [Abstract][Full Text] [Related]
7. Adenovirus vector-mediated Gli1 siRNA induces growth inhibition and apoptosis in human pancreatic cancer with Smo-dependent or Smo-independent Hh pathway activation in vitro and in vivo.
Guo J; Gao J; Li Z; Gong Y; Man X; Jin J; Wu H
Cancer Lett; 2013 Oct; 339(2):185-94. PubMed ID: 23791879
[TBL] [Abstract][Full Text] [Related]
8. Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer.
Olive KP; Jacobetz MA; Davidson CJ; Gopinathan A; McIntyre D; Honess D; Madhu B; Goldgraben MA; Caldwell ME; Allard D; Frese KK; Denicola G; Feig C; Combs C; Winter SP; Ireland-Zecchini H; Reichelt S; Howat WJ; Chang A; Dhara M; Wang L; Rückert F; Grützmann R; Pilarsky C; Izeradjene K; Hingorani SR; Huang P; Davies SE; Plunkett W; Egorin M; Hruban RH; Whitebread N; McGovern K; Adams J; Iacobuzio-Donahue C; Griffiths J; Tuveson DA
Science; 2009 Jun; 324(5933):1457-61. PubMed ID: 19460966
[TBL] [Abstract][Full Text] [Related]
9. Cyclopamine reverts acquired chemoresistance and down-regulates cancer stem cell markers in pancreatic cancer cell lines.
Yao J; An Y; Wie JS; Ji ZL; Lu ZP; Wu JL; Jiang KR; Chen P; Xu ZK; Miao Y
Swiss Med Wkly; 2011; 141():w13208. PubMed ID: 21630164
[TBL] [Abstract][Full Text] [Related]
10. Pilot clinical trial of hedgehog pathway inhibitor GDC-0449 (vismodegib) in combination with gemcitabine in patients with metastatic pancreatic adenocarcinoma.
Kim EJ; Sahai V; Abel EV; Griffith KA; Greenson JK; Takebe N; Khan GN; Blau JL; Craig R; Balis UG; Zalupski MM; Simeone DM
Clin Cancer Res; 2014 Dec; 20(23):5937-5945. PubMed ID: 25278454
[TBL] [Abstract][Full Text] [Related]
11. LKB1 inhibits breast cancer partially through repressing the Hedgehog signaling pathway.
Zhuang Z; Wang K; Cheng X; Qu X; Jiang B; Li Z; Luo J; Shao Z; Duan T
PLoS One; 2013; 8(7):e67431. PubMed ID: 23861764
[TBL] [Abstract][Full Text] [Related]
12. Hedgehog signaling in normal urothelial cells and in urothelial carcinoma cell lines.
Thievessen I; Wolter M; Prior A; Seifert HH; Schulz WA
J Cell Physiol; 2005 May; 203(2):372-7. PubMed ID: 15521068
[TBL] [Abstract][Full Text] [Related]
13. Gli3 mediates cell survival and sensitivity to cyclopamine in pancreatic cancer.
Steg A; Amm HM; Novak Z; Frost AR; Johnson MR
Cancer Biol Ther; 2010 Nov; 10(9):893-902. PubMed ID: 20814245
[TBL] [Abstract][Full Text] [Related]
14. Targeting the hedgehog signaling pathway with interacting peptides to Patched-1.
Nakamura M; Tanaka H; Nagayoshi Y; Nakashima H; Tsutsumi K; Ohtsuka T; Takahata S; Tanaka M; Okada H
J Gastroenterol; 2012 Apr; 47(4):452-60. PubMed ID: 22170414
[TBL] [Abstract][Full Text] [Related]
15. Synergism between Hedgehog-GLI and EGFR signaling in Hedgehog-responsive human medulloblastoma cells induces downregulation of canonical Hedgehog-target genes and stabilized expression of GLI1.
Götschel F; Berg D; Gruber W; Bender C; Eberl M; Friedel M; Sonntag J; Rüngeler E; Hache H; Wierling C; Nietfeld W; Lehrach H; Frischauf A; Schwartz-Albiez R; Aberger F; Korf U
PLoS One; 2013; 8(6):e65403. PubMed ID: 23762360
[TBL] [Abstract][Full Text] [Related]
16. Hedgehog-signaling is upregulated in non-producing human adrenal adenomas and antagonism of hedgehog-signaling inhibits proliferation of NCI-H295R cells and an immortalized primary human adrenal cell line.
Werminghaus P; Haase M; Hornsby PJ; Schinner S; Schott M; Malendowicz LK; Lammers BJ; Goretzki PE; Müller-Mattheis V; Markus Giessing ; Willenberg HS
J Steroid Biochem Mol Biol; 2014 Jan; 139():7-15. PubMed ID: 24063979
[TBL] [Abstract][Full Text] [Related]
17. Cyclopamine treatment of full-blown Hh/Ptch-associated RMS partially inhibits Hh/Ptch signaling, but not tumor growth.
Ecke I; Rosenberger A; Obenauer S; Dullin C; Aberger F; Kimmina S; Schweyer S; Hahn H
Mol Carcinog; 2008 May; 47(5):361-72. PubMed ID: 17963245
[TBL] [Abstract][Full Text] [Related]
18. The Hedgehog signaling pathway in ovarian teratoma is stimulated by Sonic Hedgehog which induces internalization of Patched.
Sabol M; Car D; Musani V; Ozretic P; Oreskovic S; Weber I; Levanat S
Int J Oncol; 2012 Oct; 41(4):1411-8. PubMed ID: 22797776
[TBL] [Abstract][Full Text] [Related]
19. [New therapeutic strategy for cancer targeting the hedgehog signaling pathway].
Nakamura M; Kubo M; Nagai S; Yamaguchi K; Tanaka M; Katano M
Gan To Kagaku Ryoho; 2007 Nov; 34(12):1914-6. PubMed ID: 18219851
[TBL] [Abstract][Full Text] [Related]
20. All-trans-retinoic acid antagonizes the Hedgehog pathway by inducing patched.
Busch AM; Galimberti F; Nehls KE; Roengvoraphoj M; Sekula D; Li B; Guo Y; Direnzo J; Fiering SN; Spinella MJ; Robbins DJ; Memoli VA; Freemantle SJ; Dmitrovsky E
Cancer Biol Ther; 2014 Apr; 15(4):463-72. PubMed ID: 24496080
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
