These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
133 related articles for article (PubMed ID: 22079339)
1. Mapping of the binding sites for the OX1 orexin receptor antagonist, SB-334867, using orexin/hypocretin receptor chimaeras. Putula J; Kukkonen JP Neurosci Lett; 2012 Jan; 506(1):111-5. PubMed ID: 22079339 [TBL] [Abstract][Full Text] [Related]
2. Mapping the binding pocket of dual antagonist almorexant to human orexin 1 and orexin 2 receptors: comparison with the selective OX1 antagonist SB-674042 and the selective OX2 antagonist N-ethyl-2-[(6-methoxy-pyridin-3-yl)-(toluene-2-sulfonyl)-amino]-N-pyridin-3-ylmethyl-acetamide (EMPA). Malherbe P; Roche O; Marcuz A; Kratzeisen C; Wettstein JG; Bissantz C Mol Pharmacol; 2010 Jul; 78(1):81-93. PubMed ID: 20404073 [TBL] [Abstract][Full Text] [Related]
3. Characterisation of the binding of [3H]-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor. Langmead CJ; Jerman JC; Brough SJ; Scott C; Porter RA; Herdon HJ Br J Pharmacol; 2004 Jan; 141(2):340-6. PubMed ID: 14691055 [TBL] [Abstract][Full Text] [Related]
4. Orexin/hypocretin receptor chimaeras reveal structural features important for orexin peptide distinction. Putula J; Turunen PM; Johansson L; Näsman J; Ra R; Korhonen L; Kukkonen JP FEBS Lett; 2011 May; 585(9):1368-74. PubMed ID: 21510948 [TBL] [Abstract][Full Text] [Related]
6. Both orexin receptors are expressed in rat ovaries and fluctuate with the estrous cycle: effects of orexin receptor antagonists on gonadotropins and ovulation. Silveyra P; Lux-Lantos V; Libertun C Am J Physiol Endocrinol Metab; 2007 Oct; 293(4):E977-85. PubMed ID: 17638707 [TBL] [Abstract][Full Text] [Related]
7. Study of human Orexin-1 and -2 G-protein-coupled receptors with novel and published antagonists by modeling, molecular dynamics simulations, and site-directed mutagenesis. Heifetz A; Morris GB; Biggin PC; Barker O; Fryatt T; Bentley J; Hallett D; Manikowski D; Pal S; Reifegerste R; Slack M; Law R Biochemistry; 2012 Apr; 51(15):3178-97. PubMed ID: 22448975 [TBL] [Abstract][Full Text] [Related]
9. Orexin-A is composed of a highly conserved C-terminal and a specific, hydrophilic N-terminal region, revealing the structural basis of specific recognition by the orexin-1 receptor. Takai T; Takaya T; Nakano M; Akutsu H; Nakagawa A; Aimoto S; Nagai K; Ikegami T J Pept Sci; 2006 Jul; 12(7):443-54. PubMed ID: 16429482 [TBL] [Abstract][Full Text] [Related]
10. Chimeric, mutant orexin receptors show key interactions between orexin receptors, peptides and antagonists. Tran DT; Bonaventure P; Hack M; Mirzadegan T; Dvorak C; Letavic M; Carruthers N; Lovenberg T; Sutton SW Eur J Pharmacol; 2011 Sep; 667(1-3):120-8. PubMed ID: 21679703 [TBL] [Abstract][Full Text] [Related]
11. Effects of orexins A and B on expression of orexin receptors and progesterone release in luteal and granulosa ovarian cells. Cataldi NI; Lux-Lantos VA; Libertun C Regul Pept; 2012 Oct; 178(1-3):56-63. PubMed ID: 22749989 [TBL] [Abstract][Full Text] [Related]
12. The selective orexin 1 receptor antagonist SB-334867-A impairs acquisition and consolidation but not retrieval of spatial memory in Morris water maze. Akbari E; Naghdi N; Motamedi F Peptides; 2007 Mar; 28(3):650-6. PubMed ID: 17161886 [TBL] [Abstract][Full Text] [Related]
13. Modulation of nociceptive dural input to the trigeminal nucleus caudalis via activation of the orexin 1 receptor in the rat. Holland PR; Akerman S; Goadsby PJ Eur J Neurosci; 2006 Nov; 24(10):2825-33. PubMed ID: 17156207 [TBL] [Abstract][Full Text] [Related]
14. Agonist ligand discrimination by the two orexin receptors depends on the expression system. Putula J; Turunen PM; Jäntti MH; Ekholm ME; Kukkonen JP Neurosci Lett; 2011 Apr; 494(1):57-60. PubMed ID: 21362456 [TBL] [Abstract][Full Text] [Related]
15. Biochemical and electrophysiological characterization of almorexant, a dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist: comparison with selective OX1 and OX2 antagonists. Malherbe P; Borroni E; Pinard E; Wettstein JG; Knoflach F Mol Pharmacol; 2009 Sep; 76(3):618-31. PubMed ID: 19542319 [TBL] [Abstract][Full Text] [Related]
16. Functional and binding kinetic studies make a distinction between OX1 and OX2 orexin receptor antagonists. Faedo S; Perdonà E; Antolini M; di Fabio R; Merlo Pich E; Corsi M Eur J Pharmacol; 2012 Oct; 692(1-3):1-9. PubMed ID: 22796453 [TBL] [Abstract][Full Text] [Related]
17. Biochemical and behavioural characterization of EMPA, a novel high-affinity, selective antagonist for the OX(2) receptor. Malherbe P; Borroni E; Gobbi L; Knust H; Nettekoven M; Pinard E; Roche O; Rogers-Evans M; Wettstein JG; Moreau JL Br J Pharmacol; 2009 Apr; 156(8):1326-41. PubMed ID: 19751316 [TBL] [Abstract][Full Text] [Related]
18. Pharmacological characterisation of the orexin receptor subtype mediating postsynaptic excitation in the rat dorsal raphe nucleus. Soffin EM; Gill CH; Brough SJ; Jerman JC; Davies CH Neuropharmacology; 2004 Jun; 46(8):1168-76. PubMed ID: 15111023 [TBL] [Abstract][Full Text] [Related]
19. The orexin OX(1) receptor exists predominantly as a homodimer in the basal state: potential regulation of receptor organization by both agonist and antagonist ligands. Xu TR; Ward RJ; Pediani JD; Milligan G Biochem J; 2011 Oct; 439(1):171-83. PubMed ID: 21770891 [TBL] [Abstract][Full Text] [Related]
20. Food-induced expression of orexin receptors in rat duodenal mucosa regulates the bicarbonate secretory response to orexin-A. Bengtsson MW; Mäkelä K; Sjöblom M; Uotila S; Akerman KE; Herzig KH; Flemström G Am J Physiol Gastrointest Liver Physiol; 2007 Aug; 293(2):G501-9. PubMed ID: 17585016 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]