These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

242 related articles for article (PubMed ID: 22086918)

  • 21. Differential regulation of muscarinic M1 receptors by orthosteric and allosteric ligands.
    Davis CN; Bradley SR; Schiffer HH; Friberg M; Koch K; Tolf BR; Bonhaus DW; Lameh J
    BMC Pharmacol; 2009 Dec; 9():14. PubMed ID: 19951444
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Novel Fused Arylpyrimidinone Based Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor.
    Mistry SN; Lim H; Jörg M; Capuano B; Christopoulos A; Lane JR; Scammells PJ
    ACS Chem Neurosci; 2016 May; 7(5):647-61. PubMed ID: 26891194
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Allosteric modulation of a chemogenetically modified G protein-coupled receptor.
    Abdul-Ridha A; Lane JR; Sexton PM; Canals M; Christopoulos A
    Mol Pharmacol; 2013 Feb; 83(2):521-30. PubMed ID: 23197649
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Bitopic Binding Mode of an M
    Bradley SJ; Molloy C; Bundgaard C; Mogg AJ; Thompson KJ; Dwomoh L; Sanger HE; Crabtree MD; Brooke SM; Sexton PM; Felder CC; Christopoulos A; Broad LM; Tobin AB; Langmead CJ
    Mol Pharmacol; 2018 Jun; 93(6):645-656. PubMed ID: 29695609
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Allosteric modulators of M
    Widman CJ; Ventresca S; Dietrich J; Elmslie G; Smith H; Kaup G; Wesley A; Doenecke M; Williams FE; Schiefer IT; Ellis J; Messer WS
    Sci Rep; 2024 Jun; 14(1):14901. PubMed ID: 38942828
    [TBL] [Abstract][Full Text] [Related]  

  • 26. 4-Phenylpyridin-2-one Derivatives: A Novel Class of Positive Allosteric Modulator of the M1 Muscarinic Acetylcholine Receptor.
    Mistry SN; Jörg M; Lim H; Vinh NB; Sexton PM; Capuano B; Christopoulos A; Lane JR; Scammells PJ
    J Med Chem; 2016 Jan; 59(1):388-409. PubMed ID: 26624844
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Prediction of functionally selective allosteric interactions at an M3 muscarinic acetylcholine receptor mutant using Saccharomyces cerevisiae.
    Stewart GD; Sexton PM; Christopoulos A
    Mol Pharmacol; 2010 Aug; 78(2):205-14. PubMed ID: 20466821
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Contrasting effects of allosteric and orthosteric agonists on m1 muscarinic acetylcholine receptor internalization and down-regulation.
    Thomas RL; Langmead CJ; Wood MD; Challiss RA
    J Pharmacol Exp Ther; 2009 Dec; 331(3):1086-95. PubMed ID: 19767446
    [TBL] [Abstract][Full Text] [Related]  

  • 29. New insights into the function of M4 muscarinic acetylcholine receptors gained using a novel allosteric modulator and a DREADD (designer receptor exclusively activated by a designer drug).
    Nawaratne V; Leach K; Suratman N; Loiacono RE; Felder CC; Armbruster BN; Roth BL; Sexton PM; Christopoulos A
    Mol Pharmacol; 2008 Oct; 74(4):1119-31. PubMed ID: 18628403
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Probe dependence in the allosteric modulation of a G protein-coupled receptor: implications for detection and validation of allosteric ligand effects.
    Valant C; Felder CC; Sexton PM; Christopoulos A
    Mol Pharmacol; 2012 Jan; 81(1):41-52. PubMed ID: 21989256
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Accelerated structure-based design of chemically diverse allosteric modulators of a muscarinic G protein-coupled receptor.
    Miao Y; Goldfeld DA; Moo EV; Sexton PM; Christopoulos A; McCammon JA; Valant C
    Proc Natl Acad Sci U S A; 2016 Sep; 113(38):E5675-84. PubMed ID: 27601651
    [TBL] [Abstract][Full Text] [Related]  

  • 32. M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss.
    Bradley SJ; Bourgognon JM; Sanger HE; Verity N; Mogg AJ; White DJ; Butcher AJ; Moreno JA; Molloy C; Macedo-Hatch T; Edwards JM; Wess J; Pawlak R; Read DJ; Sexton PM; Broad LM; Steinert JR; Mallucci GR; Christopoulos A; Felder CC; Tobin AB
    J Clin Invest; 2017 Feb; 127(2):487-499. PubMed ID: 27991860
    [TBL] [Abstract][Full Text] [Related]  

  • 33. An Antibody Biosensor Establishes the Activation of the M1 Muscarinic Acetylcholine Receptor during Learning and Memory.
    Butcher AJ; Bradley SJ; Prihandoko R; Brooke SM; Mogg A; Bourgognon JM; Macedo-Hatch T; Edwards JM; Bottrill AR; Challiss RA; Broad LM; Felder CC; Tobin AB
    J Biol Chem; 2016 Apr; 291(17):8862-75. PubMed ID: 26826123
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Pharmacological characterization of LY593093, an M1 muscarinic acetylcholine receptor-selective partial orthosteric agonist.
    Watt ML; Schober DA; Hitchcock S; Liu B; Chesterfield AK; McKinzie D; Felder CC
    J Pharmacol Exp Ther; 2011 Aug; 338(2):622-32. PubMed ID: 21558436
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Development of a photoactivatable allosteric ligand for the m1 muscarinic acetylcholine receptor.
    Davie BJ; Sexton PM; Capuano B; Christopoulos A; Scammells PJ
    ACS Chem Neurosci; 2014 Oct; 5(10):902-7. PubMed ID: 25188871
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Biased Profile of Xanomeline at the Recombinant Human M
    McDonald JK; van der Westhuizen ET; Pham V; Thompson G; Felder CC; Paul SM; Thal DM; Christopoulos A; Valant C
    ACS Chem Neurosci; 2022 Apr; 13(8):1206-1218. PubMed ID: 35380782
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Allostery in GPCRs: 'MWC' revisited.
    Canals M; Sexton PM; Christopoulos A
    Trends Biochem Sci; 2011 Dec; 36(12):663-72. PubMed ID: 21920759
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Molecular Mechanisms of Action of M5 Muscarinic Acetylcholine Receptor Allosteric Modulators.
    Berizzi AE; Gentry PR; Rueda P; Den Hoedt S; Sexton PM; Langmead CJ; Christopoulos A
    Mol Pharmacol; 2016 Oct; 90(4):427-36. PubMed ID: 27461343
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Molecular mechanisms of action and in vivo validation of an M4 muscarinic acetylcholine receptor allosteric modulator with potential antipsychotic properties.
    Leach K; Loiacono RE; Felder CC; McKinzie DL; Mogg A; Shaw DB; Sexton PM; Christopoulos A
    Neuropsychopharmacology; 2010 Mar; 35(4):855-69. PubMed ID: 19940843
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Direct SUMOylation of M1 muscarinic acetylcholine receptor increases its ligand-binding affinity and signal transduction.
    Xu J; Tan P; Li H; Cui Y; Qiu Y; Wang H; Zhang X; Li J; Zhu L; Zhou W; Chen H
    FASEB J; 2019 Mar; 33(3):3237-3251. PubMed ID: 30407877
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 13.