These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

168 related articles for article (PubMed ID: 22098351)

  • 1. Druggability assessment of protein-protein interfaces.
    Wanner J; Fry DC; Peng Z; Roberts J
    Future Med Chem; 2011 Dec; 3(16):2021-38. PubMed ID: 22098351
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Binding site detection and druggability index from first principles.
    Seco J; Luque FJ; Barril X
    J Med Chem; 2009 Apr; 52(8):2363-71. PubMed ID: 19296650
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Identifying and characterizing binding sites and assessing druggability.
    Halgren TA
    J Chem Inf Model; 2009 Feb; 49(2):377-89. PubMed ID: 19434839
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structure-based druggability assessment--identifying suitable targets for small molecule therapeutics.
    Fauman EB; Rai BK; Huang ES
    Curr Opin Chem Biol; 2011 Aug; 15(4):463-8. PubMed ID: 21704549
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Druggability indices for protein targets derived from NMR-based screening data.
    Hajduk PJ; Huth JR; Fesik SW
    J Med Chem; 2005 Apr; 48(7):2518-25. PubMed ID: 15801841
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Assessing the druggability of protein-protein interactions by a supervised machine-learning method.
    Sugaya N; Ikeda K
    BMC Bioinformatics; 2009 Aug; 10():263. PubMed ID: 19703312
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structure-based maximal affinity model predicts small-molecule druggability.
    Cheng AC; Coleman RG; Smyth KT; Cao Q; Soulard P; Caffrey DR; Salzberg AC; Huang ES
    Nat Biotechnol; 2007 Jan; 25(1):71-5. PubMed ID: 17211405
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Biochemical network-based drug-target prediction.
    Klipp E; Wade RC; Kummer U
    Curr Opin Biotechnol; 2010 Aug; 21(4):511-6. PubMed ID: 20554441
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Improving drug candidates by design: a focus on physicochemical properties as a means of improving compound disposition and safety.
    Meanwell NA
    Chem Res Toxicol; 2011 Sep; 24(9):1420-56. PubMed ID: 21790149
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Prediction of protein-protein interaction inhibitors by chemoinformatics and machine learning methods.
    Neugebauer A; Hartmann RW; Klein CD
    J Med Chem; 2007 Sep; 50(19):4665-8. PubMed ID: 17705363
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Small-molecule protein-protein interaction inhibitors: therapeutic potential in light of molecular size, chemical space, and ligand binding efficiency considerations.
    Buchwald P
    IUBMB Life; 2010 Oct; 62(10):724-31. PubMed ID: 20979208
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Small-molecule stabilization of protein-protein interactions: an underestimated concept in drug discovery?
    Thiel P; Kaiser M; Ottmann C
    Angew Chem Int Ed Engl; 2012 Feb; 51(9):2012-8. PubMed ID: 22308055
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structural biology and drug discovery for protein-protein interactions.
    Jubb H; Higueruelo AP; Winter A; Blundell TL
    Trends Pharmacol Sci; 2012 May; 33(5):241-8. PubMed ID: 22503442
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Understanding and predicting druggability. A high-throughput method for detection of drug binding sites.
    Schmidtke P; Barril X
    J Med Chem; 2010 Aug; 53(15):5858-67. PubMed ID: 20684613
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The Evolving Druggability and Developability Space: Chemically Modified New Modalities and Emerging Small Molecules.
    Yang W; Gadgil P; Krishnamurthy VR; Landis M; Mallick P; Patel D; Patel PJ; Reid DL; Sanchez-Felix M
    AAPS J; 2020 Jan; 22(2):21. PubMed ID: 31900602
    [TBL] [Abstract][Full Text] [Related]  

  • 16. PockDrug-Server: a new web server for predicting pocket druggability on holo and apo proteins.
    Hussein HA; Borrel A; Geneix C; Petitjean M; Regad L; Camproux AC
    Nucleic Acids Res; 2015 Jul; 43(W1):W436-42. PubMed ID: 25956651
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Predicting protein druggability.
    Hajduk PJ; Huth JR; Tse C
    Drug Discov Today; 2005 Dec; 10(23-24):1675-82. PubMed ID: 16376828
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Rational modulator design by exploitation of protein-protein complex structures.
    Wichapong K; Poelman H; Ercig B; Hrdinova J; Liu X; Lutgens E; Nicolaes GA
    Future Med Chem; 2019 May; 11(9):1015-1033. PubMed ID: 31141413
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A large-scale computational approach to drug repositioning.
    Li YY; An J; Jones SJ
    Genome Inform; 2006; 17(2):239-47. PubMed ID: 17503396
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Probing the druggability of protein-protein interactions: targeting the Notch1 receptor ankyrin domain using a fragment-based approach.
    Abdel-Rahman N; Martinez-Arias A; Blundell TL
    Biochem Soc Trans; 2011 Oct; 39(5):1327-33. PubMed ID: 21936810
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.