1504 related articles for article (PubMed ID: 22101433)
1. Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia.
Metallo CM; Gameiro PA; Bell EL; Mattaini KR; Yang J; Hiller K; Jewell CM; Johnson ZR; Irvine DJ; Guarente L; Kelleher JK; Vander Heiden MG; Iliopoulos O; Stephanopoulos G
Nature; 2011 Nov; 481(7381):380-4. PubMed ID: 22101433
[TBL] [Abstract][Full Text] [Related]
2. Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability.
Wise DR; Ward PS; Shay JE; Cross JR; Gruber JJ; Sachdeva UM; Platt JM; DeMatteo RG; Simon MC; Thompson CB
Proc Natl Acad Sci U S A; 2011 Dec; 108(49):19611-6. PubMed ID: 22106302
[TBL] [Abstract][Full Text] [Related]
3. Fatty acid labeling from glutamine in hypoxia can be explained by isotope exchange without net reductive isocitrate dehydrogenase (IDH) flux.
Fan J; Kamphorst JJ; Rabinowitz JD; Shlomi T
J Biol Chem; 2013 Oct; 288(43):31363-9. PubMed ID: 24030823
[TBL] [Abstract][Full Text] [Related]
4. Reductive carboxylation supports growth in tumour cells with defective mitochondria.
Mullen AR; Wheaton WW; Jin ES; Chen PH; Sullivan LB; Cheng T; Yang Y; Linehan WM; Chandel NS; DeBerardinis RJ
Nature; 2011 Nov; 481(7381):385-8. PubMed ID: 22101431
[TBL] [Abstract][Full Text] [Related]
5. Metabolic and mind shifts: from glucose to glutamine and acetate addictions in cancer.
Corbet C; Feron O
Curr Opin Clin Nutr Metab Care; 2015 Jul; 18(4):346-53. PubMed ID: 26001655
[TBL] [Abstract][Full Text] [Related]
6. Reductive carboxylation supports redox homeostasis during anchorage-independent growth.
Jiang L; Shestov AA; Swain P; Yang C; Parker SJ; Wang QA; Terada LS; Adams ND; McCabe MT; Pietrak B; Schmidt S; Metallo CM; Dranka BP; Schwartz B; DeBerardinis RJ
Nature; 2016 Apr; 532(7598):255-8. PubMed ID: 27049945
[TBL] [Abstract][Full Text] [Related]
7. Enhancement of de novo lipogenesis by the IDH1 and IDH2-dependent reverse TCA cycle maintains the growth and angiogenic capacity of bone marrow-derived endothelial progenitor cells under hypoxia.
He Q; Yu T; Chen J; Liang J; Lin D; Yan K; Xie Z; Song Y; Chen Z
Free Radic Biol Med; 2024 Mar; 213():327-342. PubMed ID: 38281628
[TBL] [Abstract][Full Text] [Related]
8. Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells.
Fendt SM; Bell EL; Keibler MA; Olenchock BA; Mayers JR; Wasylenko TM; Vokes NI; Guarente L; Vander Heiden MG; Stephanopoulos G
Nat Commun; 2013; 4():2236. PubMed ID: 23900562
[TBL] [Abstract][Full Text] [Related]
9. In vivo HIF-mediated reductive carboxylation is regulated by citrate levels and sensitizes VHL-deficient cells to glutamine deprivation.
Gameiro PA; Yang J; Metelo AM; Pérez-Carro R; Baker R; Wang Z; Arreola A; Rathmell WK; Olumi A; López-Larrubia P; Stephanopoulos G; Iliopoulos O
Cell Metab; 2013 Mar; 17(3):372-85. PubMed ID: 23473032
[TBL] [Abstract][Full Text] [Related]
10. Reverse TCA cycle flux through isocitrate dehydrogenases 1 and 2 is required for lipogenesis in hypoxic melanoma cells.
Filipp FV; Scott DA; Ronai ZA; Osterman AL; Smith JW
Pigment Cell Melanoma Res; 2012 May; 25(3):375-83. PubMed ID: 22360810
[TBL] [Abstract][Full Text] [Related]
11. Quantifying reductive carboxylation flux of glutamine to lipid in a brown adipocyte cell line.
Yoo H; Antoniewicz MR; Stephanopoulos G; Kelleher JK
J Biol Chem; 2008 Jul; 283(30):20621-7. PubMed ID: 18364355
[TBL] [Abstract][Full Text] [Related]
12. Distinct von Hippel-Lindau gene and hypoxia-regulated alterations in gene and protein expression patterns of renal cell carcinoma and their effects on metabolism.
Leisz S; Schulz K; Erb S; Oefner P; Dettmer K; Mougiakakos D; Wang E; Marincola FM; Stehle F; Seliger B
Oncotarget; 2015 May; 6(13):11395-406. PubMed ID: 25890500
[TBL] [Abstract][Full Text] [Related]
13. Hydrogen sulfide inhibits hypoxia- but not anoxia-induced hypoxia-inducible factor 1 activation in a von hippel-lindau- and mitochondria-dependent manner.
Kai S; Tanaka T; Daijo H; Harada H; Kishimoto S; Suzuki K; Takabuchi S; Takenaga K; Fukuda K; Hirota K
Antioxid Redox Signal; 2012 Feb; 16(3):203-16. PubMed ID: 22004513
[TBL] [Abstract][Full Text] [Related]
14. Cancer-associated isocitrate dehydrogenase 1 (IDH1) R132H mutation and d-2-hydroxyglutarate stimulate glutamine metabolism under hypoxia.
Reitman ZJ; Duncan CG; Poteet E; Winters A; Yan LJ; Gooden DM; Spasojevic I; Boros LG; Yang SH; Yan H
J Biol Chem; 2014 Aug; 289(34):23318-28. PubMed ID: 24986863
[TBL] [Abstract][Full Text] [Related]
15. Reductive TCA cycle metabolism fuels glutamine- and glucose-stimulated insulin secretion.
Zhang GF; Jensen MV; Gray SM; El K; Wang Y; Lu D; Becker TC; Campbell JE; Newgard CB
Cell Metab; 2021 Apr; 33(4):804-817.e5. PubMed ID: 33321098
[TBL] [Abstract][Full Text] [Related]
16. FASN deficiency induces a cytosol-to-mitochondria citrate flux to mitigate detachment-induced oxidative stress.
Dai W; Wang Z; Wang G; Wang QA; DeBerardinis R; Jiang L
Cell Rep; 2023 Aug; 42(8):112971. PubMed ID: 37578864
[TBL] [Abstract][Full Text] [Related]
17. Glutaminase and poly(ADP-ribose) polymerase inhibitors suppress pyrimidine synthesis and VHL-deficient renal cancers.
Okazaki A; Gameiro PA; Christodoulou D; Laviollette L; Schneider M; Chaves F; Stemmer-Rachamimov A; Yazinski SA; Lee R; Stephanopoulos G; Zou L; Iliopoulos O
J Clin Invest; 2017 May; 127(5):1631-1645. PubMed ID: 28346230
[TBL] [Abstract][Full Text] [Related]
18. Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function.
Krieg M; Haas R; Brauch H; Acker T; Flamme I; Plate KH
Oncogene; 2000 Nov; 19(48):5435-43. PubMed ID: 11114720
[TBL] [Abstract][Full Text] [Related]
19. Pathway of carbon flow during fatty acid synthesis from lactate and pyruvate in rat adipose tissue.
Patel MS; Jomain-Baum M; Ballard FJ; Hanson RW
J Lipid Res; 1971 Mar; 12(2):179-91. PubMed ID: 4396562
[TBL] [Abstract][Full Text] [Related]
20. Glutamine metabolism in AS-30D hepatoma cells. Evidence for its conversion into lipids via reductive carboxylation.
Holleran AL; Briscoe DA; Fiskum G; Kelleher JK
Mol Cell Biochem; 1995 Nov; 152(2):95-101. PubMed ID: 8751155
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
