272 related articles for article (PubMed ID: 22105362)
1. PAK1 is a breast cancer oncogene that coordinately activates MAPK and MET signaling.
Shrestha Y; Schafer EJ; Boehm JS; Thomas SR; He F; Du J; Wang S; Barretina J; Weir BA; Zhao JJ; Polyak K; Golub TR; Beroukhim R; Hahn WC
Oncogene; 2012 Jul; 31(29):3397-408. PubMed ID: 22105362
[TBL] [Abstract][Full Text] [Related]
2. A Rac-Pak signaling pathway is essential for ErbB2-mediated transformation of human breast epithelial cancer cells.
Arias-Romero LE; Villamar-Cruz O; Pacheco A; Kosoff R; Huang M; Muthuswamy SK; Chernoff J
Oncogene; 2010 Oct; 29(43):5839-49. PubMed ID: 20711231
[TBL] [Abstract][Full Text] [Related]
3. Knockdown of PAK4 or PAK1 inhibits the proliferation of mutant KRAS colon cancer cells independently of RAF/MEK/ERK and PI3K/AKT signaling.
Tabusa H; Brooks T; Massey AJ
Mol Cancer Res; 2013 Feb; 11(2):109-21. PubMed ID: 23233484
[TBL] [Abstract][Full Text] [Related]
4. Prolactin-stimulated activation of ERK1/2 mitogen-activated protein kinases is controlled by PI3-kinase/Rac/PAK signaling pathway in breast cancer cells.
Aksamitiene E; Achanta S; Kolch W; Kholodenko BN; Hoek JB; Kiyatkin A
Cell Signal; 2011 Nov; 23(11):1794-805. PubMed ID: 21726627
[TBL] [Abstract][Full Text] [Related]
5. Impact of oncogenic driver mutations on feedback between the PI3K and MEK pathways in cancer cells.
Yuen HF; Abramczyk O; Montgomery G; Chan KK; Huang YH; Sasazuki T; Shirasawa S; Gopesh S; Chan KW; Fennell D; Janne P; El-Tanani M; Murray JT
Biosci Rep; 2012 Aug; 32(4):413-22. PubMed ID: 22668349
[TBL] [Abstract][Full Text] [Related]
6. Regulatable expression of p21-activated kinase-1 promotes anchorage-independent growth and abnormal organization of mitotic spindles in human epithelial breast cancer cells.
Vadlamudi RK; Adam L; Wang RA; Mandal M; Nguyen D; Sahin A; Chernoff J; Hung MC; Kumar R
J Biol Chem; 2000 Nov; 275(46):36238-44. PubMed ID: 10945974
[TBL] [Abstract][Full Text] [Related]
7. Signal transduction pathways activated and required for mammary carcinogenesis in response to specific oncogenes.
Amundadottir LT; Leder P
Oncogene; 1998 Feb; 16(6):737-46. PubMed ID: 9488037
[TBL] [Abstract][Full Text] [Related]
8. Blockage of PAK1 alleviates the proliferation and invasion of NSCLC cells via inhibiting ERK and AKT signaling activity.
Song P; Song B; Liu J; Wang X; Nan X; Wang J
Clin Transl Oncol; 2021 Apr; 23(4):892-901. PubMed ID: 32974862
[TBL] [Abstract][Full Text] [Related]
9. TDAG51 is an ERK signaling target that opposes ERK-mediated HME16C mammary epithelial cell transformation.
Oberst MD; Beberman SJ; Zhao L; Yin JJ; Ward Y; Kelly K
BMC Cancer; 2008 Jul; 8():189. PubMed ID: 18597688
[TBL] [Abstract][Full Text] [Related]
10. MAPK- and AKT-activated thyroid cancers are sensitive to group I PAK inhibition.
Knippler CM; Saji M; Rajan N; Porter K; La Perle KMD; Ringel MD
Endocr Relat Cancer; 2019 Aug; 26(8):699-712. PubMed ID: 31146260
[TBL] [Abstract][Full Text] [Related]
11. Kinase-deficient Pak1 mutants inhibit Ras transformation of Rat-1 fibroblasts.
Tang Y; Chen Z; Ambrose D; Liu J; Gibbs JB; Chernoff J; Field J
Mol Cell Biol; 1997 Aug; 17(8):4454-64. PubMed ID: 9234703
[TBL] [Abstract][Full Text] [Related]
12. VRK2 inhibits mitogen-activated protein kinase signaling and inversely correlates with ErbB2 in human breast cancer.
Fernández IF; Blanco S; Lozano J; Lazo PA
Mol Cell Biol; 2010 Oct; 30(19):4687-97. PubMed ID: 20679487
[TBL] [Abstract][Full Text] [Related]
13. Trihydrophobin 1 Interacts with PAK1 and Regulates ERK/MAPK Activation and Cell Migration.
Cheng C; Kong X; Wang H; Gan H; Hao Y; Zou W; Wu J; Chi Y; Yang J; Hong Y; Chen K; Gu J
J Biol Chem; 2009 Mar; 284(13):8786-96. PubMed ID: 19136554
[TBL] [Abstract][Full Text] [Related]
14. alpha6beta4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-kappaB-dependent resistance to apoptosis in 3D mammary acini.
Friedland JC; Lakins JN; Kazanietz MG; Chernoff J; Boettiger D; Weaver VM
J Cell Sci; 2007 Oct; 120(Pt 20):3700-12. PubMed ID: 17911169
[TBL] [Abstract][Full Text] [Related]
15. PAK1 regulates breast cancer cell invasion through secretion of matrix metalloproteinases in response to prolactin and three-dimensional collagen IV.
Rider L; Oladimeji P; Diakonova M
Mol Endocrinol; 2013 Jul; 27(7):1048-64. PubMed ID: 23744893
[TBL] [Abstract][Full Text] [Related]
16. Pak1 regulates multiple c-Kit mediated Ras-MAPK gain-in-function phenotypes in Nf1+/- mast cells.
McDaniel AS; Allen JD; Park SJ; Jaffer ZM; Michels EG; Burgin SJ; Chen S; Bessler WK; Hofmann C; Ingram DA; Chernoff J; Clapp DW
Blood; 2008 Dec; 112(12):4646-54. PubMed ID: 18768391
[TBL] [Abstract][Full Text] [Related]
17. P21-activated kinase 1 stimulates colon cancer cell growth and migration/invasion via ERK- and AKT-dependent pathways.
Huynh N; Liu KH; Baldwin GS; He H
Biochim Biophys Acta; 2010 Sep; 1803(9):1106-13. PubMed ID: 20595063
[TBL] [Abstract][Full Text] [Related]
18. PAK1 primes MEK1 for phosphorylation by Raf-1 kinase during cross-cascade activation of the ERK pathway.
Coles LC; Shaw PE
Oncogene; 2002 Mar; 21(14):2236-44. PubMed ID: 11948406
[TBL] [Abstract][Full Text] [Related]
19. p21-activated kinase 1 (PAK1) can promote ERK activation in a kinase-independent manner.
Wang Z; Fu M; Wang L; Liu J; Li Y; Brakebusch C; Mei Q
J Biol Chem; 2013 Jul; 288(27):20093-9. PubMed ID: 23653349
[TBL] [Abstract][Full Text] [Related]
20. microRNA-542-5p protects against acute lung injury in mice with severe acute pancreatitis by suppressing the mitogen-activated protein kinase signaling pathway through the negative regulation of P21-activated kinase 1.
Wu XM; Ji KQ; Wang HY; Zhao Y; Jia J; Gao XP; Zang B
J Cell Biochem; 2019 Jan; 120(1):290-304. PubMed ID: 30216510
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]