BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

104 related articles for article (PubMed ID: 22105553)

  • 1. Mutations in isocitrate dehydrogenase 2 accelerate glioma cell migration via matrix metalloproteinase-2 and 9.
    Fu Y; Zheng Y; Li K; Huang R; Zheng S; An N; Liang A
    Biotechnol Lett; 2012 Mar; 34(3):441-6. PubMed ID: 22105553
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Lithium chloride decreases proliferation and migration of C6 glioma cells harboring isocitrate dehydrogenase 2 mutant via GSK-3β.
    Fu Y; Zheng Y; Chan KG; Liang A; Hu F
    Mol Biol Rep; 2014 Jun; 41(6):3907-13. PubMed ID: 24549719
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Glioma-derived mutations in isocitrate dehydrogenase 2 beneficial to traditional chemotherapy.
    Fu Y; Huang R; Zheng Y; Zhang Z; Liang A
    Biochem Biophys Res Commun; 2011 Jul; 410(2):218-23. PubMed ID: 21641335
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Glioma derived isocitrate dehydrogenase-2 mutations induced up-regulation of HIF-1α and β-catenin signaling: possible impact on glioma cell metastasis and chemo-resistance.
    Fu Y; Zheng S; Zheng Y; Huang R; An N; Liang A; Hu C
    Int J Biochem Cell Biol; 2012 May; 44(5):770-5. PubMed ID: 22309944
    [TBL] [Abstract][Full Text] [Related]  

  • 5. IDH mutations in glioma and acute myeloid leukemia.
    Dang L; Jin S; Su SM
    Trends Mol Med; 2010 Sep; 16(9):387-97. PubMed ID: 20692206
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Glioma-derived mutations in IDH: from mechanism to potential therapy.
    Fu Y; Huang R; Du J; Yang R; An N; Liang A
    Biochem Biophys Res Commun; 2010 Jun; 397(2):127-30. PubMed ID: 20510884
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha.
    Zhao S; Lin Y; Xu W; Jiang W; Zha Z; Wang P; Yu W; Li Z; Gong L; Peng Y; Ding J; Lei Q; Guan KL; Xiong Y
    Science; 2009 Apr; 324(5924):261-5. PubMed ID: 19359588
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Mutation of isocitrate dehydrogenase 1 induces glioma cell proliferation via nuclear factor-κB activation in a hypoxia-inducible factor 1-α dependent manner.
    Wang G; Sai K; Gong F; Yang Q; Chen F; Lin J
    Mol Med Rep; 2014 May; 9(5):1799-805. PubMed ID: 24626950
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations.
    Gross S; Cairns RA; Minden MD; Driggers EM; Bittinger MA; Jang HG; Sasaki M; Jin S; Schenkein DP; Su SM; Dang L; Fantin VR; Mak TW
    J Exp Med; 2010 Feb; 207(2):339-44. PubMed ID: 20142433
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Replication Study: The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate.
    Showalter MR; Hatakeyama J; Cajka T; VanderVorst K; Carraway KL; Fiehn O;
    Elife; 2017 Jun; 6():. PubMed ID: 28653623
    [TBL] [Abstract][Full Text] [Related]  

  • 11. MicroRNA-183 upregulates HIF-1α by targeting isocitrate dehydrogenase 2 (IDH2) in glioma cells.
    Tanaka H; Sasayama T; Tanaka K; Nakamizo S; Nishihara M; Mizukawa K; Kohta M; Koyama J; Miyake S; Taniguchi M; Hosoda K; Kohmura E
    J Neurooncol; 2013 Feb; 111(3):273-83. PubMed ID: 23263745
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases.
    Xu W; Yang H; Liu Y; Yang Y; Wang P; Kim SH; Ito S; Yang C; Wang P; Xiao MT; Liu LX; Jiang WQ; Liu J; Zhang JY; Wang B; Frye S; Zhang Y; Xu YH; Lei QY; Guan KL; Zhao SM; Xiong Y
    Cancer Cell; 2011 Jan; 19(1):17-30. PubMed ID: 21251613
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Isocitrate dehydrogenase mutations may be a protective mechanism in glioma patients.
    Zhu J; Zuo J; Xu Q; Wang X; Wang Z; Zhou D
    Med Hypotheses; 2011 Apr; 76(4):602-3. PubMed ID: 21284999
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Silencing hypoxia-inducible factor-1alpha inhibits cell migration and invasion under hypoxic environment in malignant gliomas.
    Fujiwara S; Nakagawa K; Harada H; Nagato S; Furukawa K; Teraoka M; Seno T; Oka K; Iwata S; Ohnishi T
    Int J Oncol; 2007 Apr; 30(4):793-802. PubMed ID: 17332917
    [TBL] [Abstract][Full Text] [Related]  

  • 15. R132 mutations in canine isocitrate dehydrogenase 1 (IDH1) lead to functional changes.
    Kawakami S; Ochiai K; Azakami D; Kato Y; Michishita M; Morimatsu M; Ishiguro-Oonuma T; Onozawa E; Watanabe M; Omi T
    Vet Res Commun; 2018 Mar; 42(1):49-56. PubMed ID: 29285579
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Isocitrate dehydrogenase mutations: a challenge to traditional views on the genesis and malignant progression of gliomas.
    Weller M; Wick W; von Deimling A
    Glia; 2011 Aug; 59(8):1200-4. PubMed ID: 21294161
    [TBL] [Abstract][Full Text] [Related]  

  • 17. IDH mutations associated impact on related cancer epidemiology and subsequent effect toward HIF-1α.
    Semukunzi H; Roy D; Li H; Khan GJ; Lyu X; Yuan S; Lin S
    Biomed Pharmacother; 2017 May; 89():805-811. PubMed ID: 28273642
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Identification and Characterization of Small-Molecule Inhibitors of the R132H/R132H Mutant Isocitrate Dehydrogenase 1 Homodimer and R132H/Wild-Type Heterodimer.
    Brooks E; Wu X; Hanel A; Nguyen S; Wang J; Zhang JH; Harrison A; Zhang W
    J Biomol Screen; 2014 Sep; 19(8):1193-200. PubMed ID: 24980596
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Isocitrate dehydrogenase status and molecular subclasses of glioma and glioblastoma.
    Agnihotri S; Aldape KD; Zadeh G
    Neurosurg Focus; 2014 Dec; 37(6):E13. PubMed ID: 25434382
    [TBL] [Abstract][Full Text] [Related]  

  • 20. IDH1 and IDH2 mutations in tumorigenesis: mechanistic insights and clinical perspectives.
    Yang H; Ye D; Guan KL; Xiong Y
    Clin Cancer Res; 2012 Oct; 18(20):5562-71. PubMed ID: 23071358
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.