152 related articles for article (PubMed ID: 22115592)
1. A small molecule inhibitor of p53-inducible protein phosphatase PPM1D.
Yagi H; Chuman Y; Kozakai Y; Imagawa T; Takahashi Y; Yoshimura F; Tanino K; Sakaguchi K
Bioorg Med Chem Lett; 2012 Jan; 22(1):729-32. PubMed ID: 22115592
[TBL] [Abstract][Full Text] [Related]
2. Reversal of the ATM/ATR-mediated DNA damage response by the oncogenic phosphatase PPM1D.
Lu X; Nguyen TA; Donehower LA
Cell Cycle; 2005 Aug; 4(8):1060-4. PubMed ID: 15970689
[TBL] [Abstract][Full Text] [Related]
3. Inhibition of C-terminal truncated PPM1D enhances the effect of doxorubicin on cell viability in human colorectal carcinoma cell line.
Kozakai Y; Kamada R; Kiyota Y; Yoshimura F; Tanino K; Sakaguchi K
Bioorg Med Chem Lett; 2014 Dec; 24(24):5593-5596. PubMed ID: 25466181
[TBL] [Abstract][Full Text] [Related]
4. Novel inhibitors targeting PPM1D phosphatase potently suppress cancer cell proliferation.
Ogasawara S; Kiyota Y; Chuman Y; Kowata A; Yoshimura F; Tanino K; Kamada R; Sakaguchi K
Bioorg Med Chem; 2015 Oct; 23(19):6246-9. PubMed ID: 26358280
[TBL] [Abstract][Full Text] [Related]
5. PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints.
Lu X; Nannenga B; Donehower LA
Genes Dev; 2005 May; 19(10):1162-74. PubMed ID: 15870257
[TBL] [Abstract][Full Text] [Related]
6. The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop.
Lu X; Ma O; Nguyen TA; Jones SN; Oren M; Donehower LA
Cancer Cell; 2007 Oct; 12(4):342-54. PubMed ID: 17936559
[TBL] [Abstract][Full Text] [Related]
7. Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity.
Bulavin DV; Demidov ON; Saito S; Kauraniemi P; Phillips C; Amundson SA; Ambrosino C; Sauter G; Nebreda AR; Anderson CW; Kallioniemi A; Fornace AJ; Appella E
Nat Genet; 2002 Jun; 31(2):210-5. PubMed ID: 12021785
[TBL] [Abstract][Full Text] [Related]
8. Augmented cancer resistance and DNA damage response phenotypes in PPM1D null mice.
Nannenga B; Lu X; Dumble M; Van Maanen M; Nguyen TA; Sutton R; Kumar TR; Donehower LA
Mol Carcinog; 2006 Aug; 45(8):594-604. PubMed ID: 16652371
[TBL] [Abstract][Full Text] [Related]
9. Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase.
Shreeram S; Hee WK; Demidov ON; Kek C; Yamaguchi H; Fornace AJ; Anderson CW; Appella E; Bulavin DV
J Exp Med; 2006 Dec; 203(13):2793-9. PubMed ID: 17158963
[TBL] [Abstract][Full Text] [Related]
10. Kaempferol induces apoptosis in human HCT116 colon cancer cells via the Ataxia-Telangiectasia Mutated-p53 pathway with the involvement of p53 Upregulated Modulator of Apoptosis.
Li W; Du B; Wang T; Wang S; Zhang J
Chem Biol Interact; 2009 Jan; 177(2):121-7. PubMed ID: 19028473
[TBL] [Abstract][Full Text] [Related]
11. Wip1 phosphatase modulates ATM-dependent signaling pathways.
Shreeram S; Demidov ON; Hee WK; Yamaguchi H; Onishi N; Kek C; Timofeev ON; Dudgeon C; Fornace AJ; Anderson CW; Minami Y; Appella E; Bulavin DV
Mol Cell; 2006 Sep; 23(5):757-64. PubMed ID: 16949371
[TBL] [Abstract][Full Text] [Related]
12. PPM1D phosphatase, a target of p53 and RBM38 RNA-binding protein, inhibits p53 mRNA translation via dephosphorylation of RBM38.
Zhang M; Xu E; Zhang J; Chen X
Oncogene; 2015 Nov; 34(48):5900-11. PubMed ID: 25823026
[TBL] [Abstract][Full Text] [Related]
13. The oncogenic phosphatase PPM1D confers cisplatin resistance in ovarian carcinoma cells by attenuating checkpoint kinase 1 and p53 activation.
Ali AY; Abedini MR; Tsang BK
Oncogene; 2012 Apr; 31(17):2175-86. PubMed ID: 21927021
[TBL] [Abstract][Full Text] [Related]
14. Kotomolide A arrests cell cycle progression and induces apoptosis through the induction of ATM/p53 and the initiation of mitochondrial system in human non-small cell lung cancer A549 cells.
Chen CY; Hsu YL; Tsai YC; Kuo PL
Food Chem Toxicol; 2008 Jul; 46(7):2476-84. PubMed ID: 18511169
[TBL] [Abstract][Full Text] [Related]
15. Inhibition of Ser/Thr phosphatase PPM1D induces neutrophil differentiation in HL-60 cells.
Kamada R; Kudoh F; Yoshimura F; Tanino K; Sakaguchi K
J Biochem; 2017 Oct; 162(4):303-308. PubMed ID: 28486685
[TBL] [Abstract][Full Text] [Related]
16. The Wip1 phosphatase PPM1D dephosphorylates SQ/TQ motifs in checkpoint substrates phosphorylated by PI3K-like kinases.
Yamaguchi H; Durell SR; Chatterjee DK; Anderson CW; Appella E
Biochemistry; 2007 Nov; 46(44):12594-603. PubMed ID: 17939684
[TBL] [Abstract][Full Text] [Related]
17. Targeting the PPM1D phenotype; 2,4-bisarylthiazoles cause highly selective apoptosis in PPM1D amplified cell-lines.
Cheeseman MD; Faisal A; Rayter S; Barbeau OR; Kalusa A; Westlake M; Burke R; Swan M; van Montfort R; Linardopoulos S; Jones K
Bioorg Med Chem Lett; 2014 Aug; 24(15):3469-74. PubMed ID: 24953599
[TBL] [Abstract][Full Text] [Related]
18. PPM1D regulates p21 expression via dephoshporylation at serine 123.
Cao R; Zhang J; Zhang M; Chen X
Cell Cycle; 2015; 14(4):641-7. PubMed ID: 25590690
[TBL] [Abstract][Full Text] [Related]
19. Inhibitory role of cAMP on doxorubicin-induced apoptosis in pre-B ALL cells through dephosphorylation of p53 serine residues.
Safa M; Kazemi A; Zand H; Azarkeivan A; Zaker F; Hayat P
Apoptosis; 2010 Feb; 15(2):196-203. PubMed ID: 19882354
[TBL] [Abstract][Full Text] [Related]
20. PPM1D silencing by RNA interference inhibits proliferation and induces apoptosis in breast cancer cell lines with wild-type p53.
Pärssinen J; Alarmo EL; Karhu R; Kallioniemi A
Cancer Genet Cytogenet; 2008 Apr; 182(1):33-9. PubMed ID: 18328948
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
