These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

327 related articles for article (PubMed ID: 22117896)

  • 1. Identification of target genes for the CDK subunits of the Mediator complex.
    Tsutsui T; Fukasawa R; Tanaka A; Hirose Y; Ohkuma Y
    Genes Cells; 2011 Dec; 16(12):1208-18. PubMed ID: 22117896
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Human mediator kinase subunit CDK11 plays a negative role in viral activator VP16-dependent transcriptional regulation.
    Tsutsui T; Umemura H; Tanaka A; Mizuki F; Hirose Y; Ohkuma Y
    Genes Cells; 2008 Aug; 13(8):817-26. PubMed ID: 18651850
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19.
    Park MJ; Shen H; Spaeth JM; Tolvanen JH; Failor C; Knudtson JF; McLaughlin J; Halder SK; Yang Q; Bulun SE; Al-Hendy A; Schenken RS; Aaltonen LA; Boyer TG
    J Biol Chem; 2018 Mar; 293(13):4870-4882. PubMed ID: 29440396
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Mediator complex recruits epigenetic regulators via its two cyclin-dependent kinase subunits to repress transcription of immune response genes.
    Tsutsui T; Fukasawa R; Shinmyouzu K; Nakagawa R; Tobe K; Tanaka A; Ohkuma Y
    J Biol Chem; 2013 Jul; 288(29):20955-20965. PubMed ID: 23749998
    [TBL] [Abstract][Full Text] [Related]  

  • 5. CDK8: a positive regulator of transcription.
    Galbraith MD; Donner AJ; Espinosa JM
    Transcription; 2010; 1(1):4-12. PubMed ID: 21327159
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Cyclin-dependent kinase 8 positively cooperates with Mediator to promote thyroid hormone receptor-dependent transcriptional activation.
    Belakavadi M; Fondell JD
    Mol Cell Biol; 2010 May; 30(10):2437-48. PubMed ID: 20231357
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Mediator cyclin-dependent kinases upregulate transcription of inflammatory genes in cooperation with NF-κB and C/EBPβ on stimulation of Toll-like receptor 9.
    Yamamoto S; Hagihara T; Horiuchi Y; Okui A; Wani S; Yoshida T; Inoue T; Tanaka A; Ito T; Hirose Y; Ohkuma Y
    Genes Cells; 2017 Mar; 22(3):265-276. PubMed ID: 28151579
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Transcriptional Responses to IFN-γ Require Mediator Kinase-Dependent Pause Release and Mechanistically Distinct CDK8 and CDK19 Functions.
    Steinparzer I; Sedlyarov V; Rubin JD; Eislmayr K; Galbraith MD; Levandowski CB; Vcelkova T; Sneezum L; Wascher F; Amman F; Kleinova R; Bender H; Andrysik Z; Espinosa JM; Superti-Furga G; Dowell RD; Taatjes DJ; Kovarik P
    Mol Cell; 2019 Nov; 76(3):485-499.e8. PubMed ID: 31495563
    [TBL] [Abstract][Full Text] [Related]  

  • 9. A kinase subunit of the human mediator complex, CDK8, positively regulates transcriptional activation.
    Furumoto T; Tanaka A; Ito M; Malik S; Hirose Y; Hanaoka F; Ohkuma Y
    Genes Cells; 2007 Jan; 12(1):119-32. PubMed ID: 17212659
    [TBL] [Abstract][Full Text] [Related]  

  • 10. A Kinase-Independent Role for Cyclin-Dependent Kinase 19 in p53 Response.
    Audetat KA; Galbraith MD; Odell AT; Lee T; Pandey A; Espinosa JM; Dowell RD; Taatjes DJ
    Mol Cell Biol; 2017 Jul; 37(13):. PubMed ID: 28416637
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Mediator CDK subunits are platforms for interactions with various chromatin regulatory complexes.
    Fukasawa R; Tsutsui T; Hirose Y; Tanaka A; Ohkuma Y
    J Biochem; 2012 Sep; 152(3):241-9. PubMed ID: 22668559
    [TBL] [Abstract][Full Text] [Related]  

  • 12. HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia.
    Galbraith MD; Allen MA; Bensard CL; Wang X; Schwinn MK; Qin B; Long HW; Daniels DL; Hahn WC; Dowell RD; Espinosa JM
    Cell; 2013 Jun; 153(6):1327-39. PubMed ID: 23746844
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Regulatory functions of the Mediator kinases CDK8 and CDK19.
    Fant CB; Taatjes DJ
    Transcription; 2019 Apr; 10(2):76-90. PubMed ID: 30585107
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Pan-Cancer Analysis of the Mediator Complex Transcriptome Identifies CDK19 and CDK8 as Therapeutic Targets in Advanced Prostate Cancer.
    Brägelmann J; Klümper N; Offermann A; von Mässenhausen A; Böhm D; Deng M; Queisser A; Sanders C; Syring I; Merseburger AS; Vogel W; Sievers E; Vlasic I; Carlsson J; Andrén O; Brossart P; Duensing S; Svensson MA; Adler D; Kirfel J; Perner S
    Clin Cancer Res; 2017 Apr; 23(7):1829-1840. PubMed ID: 27678455
    [No Abstract]   [Full Text] [Related]  

  • 15. Inhibition of Cyclin-Dependent Kinase 8/Cyclin-Dependent Kinase 19 Suppresses Its Pro-Oncogenic Effects in Prostate Cancer.
    Offermann A; Joerg V; Becker F; Roesch MC; Kang D; Lemster AL; Tharun L; Behrends J; Merseburger AS; Culig Z; Sailer V; Brägelmann J; Kirfel J; Perner S
    Am J Pathol; 2022 May; 192(5):813-823. PubMed ID: 35181333
    [TBL] [Abstract][Full Text] [Related]  

  • 16. CDK8 and CDK19: positive regulators of signal-induced transcription and negative regulators of Mediator complex proteins.
    Chen M; Li J; Zhang L; Wang L; Cheng C; Ji H; Altilia S; Ding X; Cai G; Altomare D; Shtutman M; Byrum SD; Mackintosh SG; Feoktistov A; Soshnikova N; Mogila VA; Tatarskiy V; Erokhin M; Chetverina D; Prawira A; Ni Y; Urban S; McInnes C; Broude EV; Roninson IB
    Nucleic Acids Res; 2023 Aug; 51(14):7288-7313. PubMed ID: 37378433
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Uterine leiomyoma-linked MED12 mutations disrupt mediator-associated CDK activity.
    Turunen M; Spaeth JM; Keskitalo S; Park MJ; Kivioja T; Clark AD; Mäkinen N; Gao F; Palin K; Nurkkala H; Vähärautio A; Aavikko M; Kämpjärvi K; Vahteristo P; Kim CA; Aaltonen LA; Varjosalo M; Taipale J; Boyer TG
    Cell Rep; 2014 May; 7(3):654-60. PubMed ID: 24746821
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Cyclin C influences the timing of mitosis in fission yeast.
    Banyai G; Szilagyi Z; Baraznenok V; Khorosjutina O; Gustafsson CM
    Mol Biol Cell; 2017 Jul; 28(13):1738-1744. PubMed ID: 28515143
    [TBL] [Abstract][Full Text] [Related]  

  • 19. CDK8/19 Mediator kinases potentiate induction of transcription by NFκB.
    Chen M; Liang J; Ji H; Yang Z; Altilia S; Hu B; Schronce A; McDermott MSJ; Schools GP; Lim CU; Oliver D; Shtutman MS; Lu T; Stark GR; Porter DC; Broude EV; Roninson IB
    Proc Natl Acad Sci U S A; 2017 Sep; 114(38):10208-10213. PubMed ID: 28855340
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Increased mediator complex subunit CDK19 expression associates with aggressive prostate cancer.
    Becker F; Joerg V; Hupe MC; Roth D; Krupar R; Lubczyk V; Kuefer R; Sailer V; Duensing S; Kirfel J; Merseburger AS; Brägelmann J; Perner S; Offermann A
    Int J Cancer; 2020 Jan; 146(2):577-588. PubMed ID: 31271443
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 17.