137 related articles for article (PubMed ID: 2214770)
1. 7-substituted 1,4,6-androstatriene-3,17-diones as enzyme-activated irreversible inhibitors of aromatase.
Li PK; Brueggemeier RW
J Steroid Biochem; 1990 Aug; 36(6):533-9. PubMed ID: 2214770
[TBL] [Abstract][Full Text] [Related]
2. Synthesis and biochemical studies of 7 alpha-substituted androsta-1,4-diene-3,17-diones as enzyme-activated irreversible inhibitors of aromatase.
Ebrahimian S; Chen HH; Brueggemeier RW
Steroids; 1993 Sep; 58(9):414-22. PubMed ID: 8236327
[TBL] [Abstract][Full Text] [Related]
3. Aromatase inhibition by 7-substituted steroids in human choriocarcinoma cell culture.
Brueggemeier RW; Katlic NE; Kenreigh CA; Li PK
J Steroid Biochem Mol Biol; 1992 Jan; 41(1):85-90. PubMed ID: 1734938
[TBL] [Abstract][Full Text] [Related]
4. A new hypothesis based on suicide substrate inhibitor studies for the mechanism of action of aromatase.
Covey DF; Hood WF
Cancer Res; 1982 Aug; 42(8 Suppl):3327s-3333s. PubMed ID: 7083195
[TBL] [Abstract][Full Text] [Related]
5. Aromatase inhibitors: effect of ring A and ring B unsaturation on aromatase inhibition by 4-thiosubstituted derivatives of 4-androstene-3,17-dione.
Abul-Hajj YJ; Liu XP; Hedge M
Steroids; 1995 May; 60(5):423-7. PubMed ID: 7570717
[TBL] [Abstract][Full Text] [Related]
6. Synthesis and biochemical studies of 7-substituted 4,6-androstadiene-3,17-diones as aromatase inhibitors.
Li PK; Brueggemeier RW
J Med Chem; 1990 Jan; 33(1):101-5. PubMed ID: 2296006
[TBL] [Abstract][Full Text] [Related]
7. Aromatase inactivation by a suicide substrate, androst-5-ene-4,7,17-trione: the 5beta,6beta-epoxy-19-oxo derivative, as a possible reactive electrophile irreversibly binding to the active site.
Numazawa M; Tachibana M
Biol Pharm Bull; 1997 May; 20(5):490-5. PubMed ID: 9178927
[TBL] [Abstract][Full Text] [Related]
8. 7-substituted steroidal aromatase inhibitors: structure-activity relationships and molecular modeling.
Li PK; Brueggemeier RW
J Enzyme Inhib; 1990; 4(2):113-20. PubMed ID: 2098517
[TBL] [Abstract][Full Text] [Related]
9. Enzyme-generated intermediates derived from 4-androstene-3,6,17-trione and 1,4,6-androstatriene-3,17-dione cause a time-dependent decrease in human placental aromatase activity.
Covey DF; Hood WF
Endocrinology; 1981 Apr; 108(4):1597-9. PubMed ID: 7472286
[TBL] [Abstract][Full Text] [Related]
10. Studies directed toward a mechanistic evaluation of aromatase inhibition by androst-5-ene-7,17-dione. Time-dependent inactivation by the 19-nor and 5 beta, 6 beta-epoxy derivatives.
Numazawa M; Tachibana M
Steroids; 1997 Jul; 62(7):516-22. PubMed ID: 9253790
[TBL] [Abstract][Full Text] [Related]
11. Novel 19-(cyclopropylamino)-androst-4-en-3,17-dione: a mechanism-based inhibitor of aromatase.
Njar VC; Düerkop J; Hartmann RW
J Enzyme Inhib; 1996; 10(1):47-56. PubMed ID: 8835929
[TBL] [Abstract][Full Text] [Related]
12. 6-Alkylandrosta-4,6-diene-3,17-diones and their 1,4,6-triene analogs as aromatase inhibitors. Structure-activity relationships.
Numazawa M; Oshibe M; Yamaguchi S
Steroids; 1997; 62(8-9):595-602. PubMed ID: 9292934
[TBL] [Abstract][Full Text] [Related]
13. Time-dependent inactivation of aromatase by 6-alkylandrosta-1,4-diene-3,17-diones. Effects of length and configuration of 6-alkyl group.
Numazawa M; Oshibe M; Yamaguchi S; Tachibana M
J Med Chem; 1996 Mar; 39(5):1033-8. PubMed ID: 8676338
[TBL] [Abstract][Full Text] [Related]
14. Mechanism for aromatase inactivation by a suicide substrate, androst-4-ene-3,6,17-trione. The 4 beta, 5 beta-epoxy-19-oxo derivative as a reactive electrophile irreversibly binding to the active site.
Numazawa M; Mutsumi A; Tachibana M
Biochem Pharmacol; 1996 Oct; 52(8):1253-9. PubMed ID: 8937433
[TBL] [Abstract][Full Text] [Related]
15. Steroidal inhibitors as chemical probes of the active site of aromatase.
Brueggemeir RW; Moh PP; Ebrahimian S; Darby MV
J Steroid Biochem Mol Biol; 1993 Mar; 44(4-6):357-65. PubMed ID: 8476749
[TBL] [Abstract][Full Text] [Related]
16. A time-dependent inactivation of aromatase by 19-substituted androst-4-ene-3,6,17-triones.
Numazawa M; Mutsumi A; Asano N; Ito Y
Steroids; 1993 Jan; 58(1):40-6. PubMed ID: 8430444
[TBL] [Abstract][Full Text] [Related]
17. Covalent modification of aromatase by a radiolabeled irreversible inhibitor.
Snider CE; Brueggemeier RW
J Steroid Biochem; 1985 Mar; 22(3):325-30. PubMed ID: 3990283
[TBL] [Abstract][Full Text] [Related]
18. Thiol-containing androgens as suicide substrates of aromatase.
Bednarski PJ; Porubek DJ; Nelson SD
J Med Chem; 1985 Jun; 28(6):775-9. PubMed ID: 4009599
[TBL] [Abstract][Full Text] [Related]
19. Time-dependent aromatase inactivation by 4 beta,5 beta-epoxides of the natural substrate androstenedione and its 19-oxygenated analogs.
Numazawa M; Yoshimura A; Tachibana M; Shelangouski M; Ishikawa M
Steroids; 2002 Mar; 67(3-4):185-93. PubMed ID: 11856542
[TBL] [Abstract][Full Text] [Related]
20. Studies of the time-dependent inactivation of aromatase by 4beta,5beta-epoxy-6-one and 5beta,6beta-epoxy-4-one steroids under various conditions.
Numazawa M; Yamada K
Biol Pharm Bull; 1999 Nov; 22(11):1207-11. PubMed ID: 10598029
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]