335 related articles for article (PubMed ID: 22148292)
21. Synthesis and biological properties of highly sequence-specific-alkylating N-methylpyrrole-N-methylimidazole polyamide conjugates.
Kashiwazaki G; Bando T; Yoshidome T; Masui S; Takagaki T; Hashiya K; Pandian GN; Yasuoka J; Akiyoshi K; Sugiyama H
J Med Chem; 2012 Mar; 55(5):2057-66. PubMed ID: 22309169
[TBL] [Abstract][Full Text] [Related]
22. A novel class of in vivo active anticancer agents: achiral seco-amino- and seco-hydroxycyclopropylbenz[e]indolone (seco-CBI) analogues of the duocarmycins and CC-1065.
Sato A; McNulty L; Cox K; Kim S; Scott A; Daniell K; Summerville K; Price C; Hudson S; Kiakos K; Hartley JA; Asao T; Lee M
J Med Chem; 2005 Jun; 48(11):3903-18. PubMed ID: 15916443
[TBL] [Abstract][Full Text] [Related]
23. Antibody-directed enzyme prodrug therapy: a promising approach for a selective treatment of cancer based on prodrugs and monoclonal antibodies.
Tietze LF; Krewer B
Chem Biol Drug Des; 2009 Sep; 74(3):205-11. PubMed ID: 19660031
[TBL] [Abstract][Full Text] [Related]
24. Synthesis and evaluation of stable bidentate transition metal complexes of 1-(chloromethyl)-5-hydroxy-3-(5,6,7-trimethoxyindol-2-ylcarbonyl)-2,3-dihydro-1H-pyrrolo[3,2-f]quinoline (seco-6-azaCBI-TMI) as hypoxia selective cytotoxins.
Milbank JB; Stevenson RJ; Ware DC; Chang JY; Tercel M; Ahn GO; Wilson WR; Denny WA
J Med Chem; 2009 Nov; 52(21):6822-34. PubMed ID: 19821576
[TBL] [Abstract][Full Text] [Related]
25. Preparation and antitumour properties of the enantiomers of a hypoxia-selective nitro analogue of the duocarmycins.
Tercel M; Lee HH; Yang S; Liyanage HD; Mehta SY; Boyd PD; Jaiswal JK; Tan KL; Pruijn FB
ChemMedChem; 2011 Oct; 6(10):1860-71. PubMed ID: 21793220
[TBL] [Abstract][Full Text] [Related]
26. Novel fluorinated prodrugs for activation by carboxypeptidase G2 showing good in vivo antitumor activity in gene-directed enzyme prodrug therapy.
Davies LC; Friedlos F; Hedley D; Martin J; Ogilvie LM; Scanlon IJ; Springer CJ
J Med Chem; 2005 Aug; 48(16):5321-8. PubMed ID: 16078849
[TBL] [Abstract][Full Text] [Related]
27. Synthesis and biophysical characterization of chlorambucil anticancer ether lipid prodrugs.
Pedersen PJ; Christensen MS; Ruysschaert T; Linderoth L; Andresen TL; Melander F; Mouritsen OG; Madsen R; Clausen MH
J Med Chem; 2009 May; 52(10):3408-15. PubMed ID: 19402667
[TBL] [Abstract][Full Text] [Related]
28. Aziridinyldinitrobenzamides: synthesis and structure-activity relationships for activation by E. coli nitroreductase.
Helsby NA; Atwell GJ; Yang S; Palmer BD; Anderson RF; Pullen SM; Ferry DM; Hogg A; Wilson WR; Denny WA
J Med Chem; 2004 Jun; 47(12):3295-307. PubMed ID: 15163209
[TBL] [Abstract][Full Text] [Related]
29. Disulfide prodrugs of albitiazolium (T3/SAR97276): synthesis and biological activities.
Caldarelli SA; Hamel M; Duckert JF; Ouattara M; Calas M; Maynadier M; Wein S; Périgaud C; Pellet A; Vial HJ; Peyrottes S
J Med Chem; 2012 May; 55(10):4619-28. PubMed ID: 22591034
[TBL] [Abstract][Full Text] [Related]
30. Design, synthesis, DNA binding, and biological evaluation of water-soluble hybrid molecules containing two pyrazole analogues of the alkylating cyclopropylpyrroloindole (CPI) subunit of the antitumor agent CC-1065 and polypyrrole minor groove binders.
Baraldi PG; Balboni G; Pavani MG; Spalluto G; Tabrizi MA; Clercq ED; Balzarini J; Bando T; Sugiyama H; Romagnoli R
J Med Chem; 2001 Aug; 44(16):2536-43. PubMed ID: 11472207
[TBL] [Abstract][Full Text] [Related]
31. Asymmetric synthesis and biological evaluation of glycosidic prodrugs for a selective cancer therapy.
Tietze LF; von Hof JM; Krewer B; Müller M; Major F; Schuster HJ; Schuberth I; Alves F
ChemMedChem; 2008 Dec; 3(12):1946-55. PubMed ID: 19021160
[TBL] [Abstract][Full Text] [Related]
32. Disulfide-linked antibody-maytansinoid conjugates: optimization of in vivo activity by varying the steric hindrance at carbon atoms adjacent to the disulfide linkage.
Kellogg BA; Garrett L; Kovtun Y; Lai KC; Leece B; Miller M; Payne G; Steeves R; Whiteman KR; Widdison W; Xie H; Singh R; Chari RV; Lambert JM; Lutz RJ
Bioconjug Chem; 2011 Apr; 22(4):717-27. PubMed ID: 21425776
[TBL] [Abstract][Full Text] [Related]
33. Design, synthesis and biological activity of protaxols.
Nicolaou KC; Riemer C; Kerr MA; Rideout D; Wrasidlo W
Nature; 1993 Jul; 364(6436):464-6. PubMed ID: 8101355
[TBL] [Abstract][Full Text] [Related]
34. DNA-Directed alkylating agents. 7. Synthesis, DNA interaction, and antitumor activity of bis(hydroxymethyl)- and bis(carbamate)-substituted pyrrolizines and imidazoles.
Atwell GJ; Fan JY; Tan K; Denny WA
J Med Chem; 1998 Nov; 41(24):4744-54. PubMed ID: 9822545
[TBL] [Abstract][Full Text] [Related]
35. Synthesis of the first spacer containing prodrug of a duocarmycin analogue and determination of its biological activity.
Schuster HJ; Krewer B; von Hof JM; Schmuck K; Schuberth I; Alves F; Tietze LF
Org Biomol Chem; 2010 Apr; 8(8):1833-42. PubMed ID: 20449487
[TBL] [Abstract][Full Text] [Related]
36. Synthesis and biological evaluation of prodrugs based on the natural antibiotic duocarmycin for use in ADEPT and PMT.
Tietze LF; Schmuck K; Schuster HJ; Müller M; Schuberth I
Chemistry; 2011 Feb; 17(6):1922-9. PubMed ID: 21274943
[TBL] [Abstract][Full Text] [Related]
37. Novel prodrugs of tegafur that display improved anticancer activity and antiangiogenic properties.
Engel D; Nudelman A; Tarasenko N; Levovich I; Makarovsky I; Sochotnikov S; Tarasenko I; Rephaeli A
J Med Chem; 2008 Jan; 51(2):314-23. PubMed ID: 18163551
[TBL] [Abstract][Full Text] [Related]
38. Targeted cancer therapy: conferring specificity to cytotoxic drugs.
Chari RV
Acc Chem Res; 2008 Jan; 41(1):98-107. PubMed ID: 17705444
[TBL] [Abstract][Full Text] [Related]
39. Design and synthesis of brefeldin A sulfide derivatives as prodrug candidates with enhanced aqueous solubilities.
Argade AB; Devraj R; Vroman JA; Haugwitz RD; Hollingshead M; Cushman M
J Med Chem; 1998 Aug; 41(18):3337-46. PubMed ID: 9719586
[TBL] [Abstract][Full Text] [Related]
40. Prodrugs of anthracyclines for use in antibody-directed enzyme prodrug therapy.
Florent JC; Dong X; Gaudel G; Mitaku S; Monneret C; Gesson JP; Jacquesy JC; Mondon M; Renoux B; Andrianomenjanahary S; Michel S; Koch M; Tillequin F; Gerken M; Czech J; Straub R; Bosslet K
J Med Chem; 1998 Sep; 41(19):3572-81. PubMed ID: 9733483
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]