BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

98 related articles for article (PubMed ID: 22148323)

  • 1. Maximizing lipophilic efficiency: the use of Free-Wilson analysis in the design of inhibitors of acetyl-CoA carboxylase.
    Freeman-Cook KD; Amor P; Bader S; Buzon LM; Coffey SB; Corbett JW; Dirico KJ; Doran SD; Elliott RL; Esler W; Guzman-Perez A; Henegar KE; Houser JA; Jones CS; Limberakis C; Loomis K; McPherson K; Murdande S; Nelson KL; Phillion D; Pierce BS; Song W; Sugarman E; Tapley S; Tu M; Zhao Z
    J Med Chem; 2012 Jan; 55(2):935-42. PubMed ID: 22148323
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis and structure-activity relationships of N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1- methylprop-2-ynyl}carboxy derivatives as selective acetyl-CoA carboxylase 2 inhibitors.
    Gu YG; Weitzberg M; Clark RF; Xu X; Li Q; Zhang T; Hansen TM; Liu G; Xin Z; Wang X; Wang R; McNally T; Zinker BA; Frevert EU; Camp HS; Beutel BA; Sham HL
    J Med Chem; 2006 Jun; 49(13):3770-3. PubMed ID: 16789734
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats.
    Bengtsson C; Blaho S; Saitton DB; Brickmann K; Broddefalk J; Davidsson O; Drmota T; Folmer R; Hallberg K; Hallén S; Hovland R; Isin E; Johannesson P; Kull B; Larsson LO; Löfgren L; Nilsson KE; Noeske T; Oakes N; Plowright AT; Schnecke V; Ståhlberg P; Sörme P; Wan H; Wellner E; Oster L
    Bioorg Med Chem; 2011 May; 19(10):3039-53. PubMed ID: 21515056
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Symmetrical approach of spiro-pyrazolidinediones as acetyl-CoA carboxylase inhibitors.
    Kamata M; Yamashita T; Kina A; Tawada M; Endo S; Mizukami A; Sasaki M; Tani A; Nakano Y; Watanabe Y; Furuyama N; Funami M; Amano N; Fukatsu K
    Bioorg Med Chem Lett; 2012 Jul; 22(14):4769-72. PubMed ID: 22677317
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Design, synthesis, and structure-activity relationships of novel spiro-piperidines as acetyl-CoA carboxylase inhibitors.
    Kamata M; Yamashita T; Kina A; Funata M; Mizukami A; Sasaki M; Tani A; Funami M; Amano N; Fukatsu K
    Bioorg Med Chem Lett; 2012 Jun; 22(11):3643-7. PubMed ID: 22560583
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Phenoxy thiazole derivatives as potent and selective acetyl-CoA carboxylase 2 inhibitors: Modulation of isozyme selectivity by incorporation of phenyl ring substituents.
    Clark RF; Zhang T; Wang X; Wang R; Zhang X; Camp HS; Beutel BA; Sham HL; Gu YG
    Bioorg Med Chem Lett; 2007 Apr; 17(7):1961-5. PubMed ID: 17267221
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis of 7-oxo-dihydrospiro[indazole-5,4'-piperidine] acetyl-CoA carboxylase inhibitors.
    Bagley SW; Southers JA; Cabral S; Rose CR; Bernhardson DJ; Edmonds DJ; Polivkova J; Yang X; Kung DW; Griffith DA; Bader SJ
    J Org Chem; 2012 Feb; 77(3):1497-506. PubMed ID: 22239115
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Identification and synthesis of novel inhibitors of acetyl-CoA carboxylase with in vitro and in vivo efficacy on fat oxidation.
    Keil S; Müller M; Zoller G; Haschke G; Schroeter K; Glien M; Ruf S; Focken I; Herling AW; Schmoll D
    J Med Chem; 2010 Dec; 53(24):8679-87. PubMed ID: 21082864
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis of spiro[chroman-2,4'-piperidin]-4-one derivatives as acetyl-CoA carboxylase inhibitors.
    Shinde P; Srivastava SK; Odedara R; Tuli D; Munshi S; Patel J; Zambad SP; Sonawane R; Gupta RC; Chauthaiwale V; Dutt C
    Bioorg Med Chem Lett; 2009 Feb; 19(3):949-53. PubMed ID: 19097787
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Expression, purification, and characterization of human and rat acetyl coenzyme A carboxylase (ACC) isozymes.
    Cheng D; Chu CH; Chen L; Feder JN; Mintier GA; Wu Y; Cook JW; Harpel MR; Locke GA; An Y; Tamura JK
    Protein Expr Purif; 2007 Jan; 51(1):11-21. PubMed ID: 16854592
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis and in vitro evaluation of novel spiroketopyrazoles as acetyl-CoA carboxylase inhibitors and potential antitumor agents.
    Huang T; Wu X; Yan S; Liu T; Yin X
    Eur J Med Chem; 2021 Feb; 212():113036. PubMed ID: 33276990
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Expression of genes regulating malonyl-CoA in human skeletal muscle.
    Pender C; Trentadue AR; Pories WJ; Dohm GL; Houmard JA; Youngren JF
    J Cell Biochem; 2006 Oct; 99(3):860-7. PubMed ID: 16721829
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Potent biphenyl- and 3-phenyl pyridine-based inhibitors of acetyl-CoA carboxylase.
    Haque TS; Liang N; Golla R; Seethala R; Ma Z; Ewing WR; Cooper CB; Pelleymounter MA; Poss MA; Cheng D
    Bioorg Med Chem Lett; 2009 Oct; 19(20):5872-6. PubMed ID: 19740659
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Design, synthesis and biological evaluation of novel spiro-pentacylamides as acetyl-CoA carboxylase inhibitors.
    Wei Q; Mei L; Yang Y; Ma H; Chen H; Zhang H; Zhou J
    Bioorg Med Chem; 2018 Aug; 26(14):3866-3874. PubMed ID: 30049586
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Hepatic de novo lipogenesis is present in liver-specific ACC1-deficient mice.
    Harada N; Oda Z; Hara Y; Fujinami K; Okawa M; Ohbuchi K; Yonemoto M; Ikeda Y; Ohwaki K; Aragane K; Tamai Y; Kusunoki J
    Mol Cell Biol; 2007 Mar; 27(5):1881-8. PubMed ID: 17210641
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase.
    Kung DW; Griffith DA; Esler WP; Vajdos FF; Mathiowetz AM; Doran SD; Amor PA; Bagley SW; Banks T; Cabral S; Ford K; Garcia-Irizarry CN; Landis MS; Loomis K; McPherson K; Niosi M; Rockwell KL; Rose C; Smith AC; Southers JA; Tapley S; Tu M; Valentine JJ
    Bioorg Med Chem Lett; 2015 Nov; 25(22):5352-6. PubMed ID: 26411795
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Design of selective, ATP-competitive inhibitors of Akt.
    Freeman-Cook KD; Autry C; Borzillo G; Gordon D; Barbacci-Tobin E; Bernardo V; Briere D; Clark T; Corbett M; Jakubczak J; Kakar S; Knauth E; Lippa B; Luzzio MJ; Mansour M; Martinelli G; Marx M; Nelson K; Pandit J; Rajamohan F; Robinson S; Subramanyam C; Wei L; Wythes M; Morris J
    J Med Chem; 2010 Jun; 53(12):4615-22. PubMed ID: 20481595
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Gene expression analysis in rats treated with experimental acetyl-coenzyme A carboxylase inhibitors suggests interactions with the peroxisome proliferator-activated receptor alpha pathway.
    Waring JF; Yang Y; Healan-Greenberg CH; Adler AL; Dickinson R; McNally T; Wang X; Weitzberg M; Xu X; Lisowski A; Warder SE; Gu YG; Zinker BA; Blomme EA; Camp HS
    J Pharmacol Exp Ther; 2008 Feb; 324(2):507-16. PubMed ID: 18025247
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2.
    Abu-Elheiga L; Matzuk MM; Abo-Hashema KA; Wakil SJ
    Science; 2001 Mar; 291(5513):2613-6. PubMed ID: 11283375
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Acetyl-CoA carboxylase inhibition for the treatment of metabolic syndrome.
    Harwood HJ
    Curr Opin Investig Drugs; 2004 Mar; 5(3):283-9. PubMed ID: 15083594
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 5.