BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

177 related articles for article (PubMed ID: 22174819)

  • 1. Antitumor activity of a novel oncrasin analogue is mediated by JNK activation and STAT3 inhibition.
    Guo W; Wu S; Wang L; Wei X; Liu X; Wang J; Lu Z; Hollingshead M; Fang B
    PLoS One; 2011; 6(12):e28487. PubMed ID: 22174819
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Antagonistic effect of flavonoids on NSC-741909-mediated antitumor activity via scavenging of reactive oxygen species.
    Guo W; Wei X; Wu S; Wang L; Peng H; Wang J; Fang B
    Eur J Pharmacol; 2010 Dec; 649(1-3):51-8. PubMed ID: 20854805
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Oxidative stress in NSC-741909-induced apoptosis of cancer cells.
    Wei X; Guo W; Wu S; Wang L; Huang P; Liu J; Fang B
    J Transl Med; 2010 Apr; 8():37. PubMed ID: 20398386
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Prodrug oncrasin-266 improves the stability, pharmacokinetics, and safety of NSC-743380.
    Wu S; Wang L; Huang X; Cao M; Hu J; Li H; Zhang H; Sun X; Meng QH; Hofstetter WL; Roth JA; Swisher SG; Fang B
    Bioorg Med Chem; 2014 Oct; 22(19):5234-40. PubMed ID: 25182964
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Inhibiting JNK dephosphorylation and induction of apoptosis by novel anticancer agent NSC-741909 in cancer cells.
    Wei X; Guo W; Wu S; Wang L; Lu Y; Xu B; Liu J; Fang B
    J Biol Chem; 2009 Jun; 284(25):16948-16955. PubMed ID: 19414586
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Oncrasin targets the JNK-NF-κB axis to sensitize glioma cells to TNFα-induced apoptosis.
    Gupta P; Dixit D; Sen E
    Carcinogenesis; 2013 Feb; 34(2):388-96. PubMed ID: 23125226
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Protein Kinase RNA-Like Endoplasmic Reticulum Kinase-Mediated Bcl-2 Protein Phosphorylation Contributes to Evodiamine-Induced Apoptosis of Human Renal Cell Carcinoma Cells.
    Wu WS; Chien CC; Chen YC; Chiu WT
    PLoS One; 2016; 11(8):e0160484. PubMed ID: 27483435
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Identification of a small molecule with synthetic lethality for K-ras and protein kinase C iota.
    Guo W; Wu S; Liu J; Fang B
    Cancer Res; 2008 Sep; 68(18):7403-8. PubMed ID: 18794128
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Analogues and derivatives of oncrasin-1, a novel inhibitor of the C-terminal domain of RNA polymerase II and their antitumor activities.
    Wu S; Wang L; Guo W; Liu X; Liu J; Wei X; Fang B
    J Med Chem; 2011 Apr; 54(8):2668-79. PubMed ID: 21443218
    [TBL] [Abstract][Full Text] [Related]  

  • 10. LLY17, a novel small molecule STAT3 inhibitor induces apoptosis and suppresses cell migration and tumor growth in triple-negative breast cancer.
    Pan L; Chen X; Fu S; Yu W; Li C; Wang T; Lo HW; Lin J
    Breast Cancer Res Treat; 2020 May; 181(1):31-41. PubMed ID: 32240456
    [TBL] [Abstract][Full Text] [Related]  

  • 11. A novel 7-bromoindirubin with potent anticancer activity suppresses survival of human melanoma cells associated with inhibition of STAT3 and Akt signaling.
    Liu L; Kritsanida M; Magiatis P; Gaboriaud N; Wang Y; Wu J; Buettner R; Yang F; Nam S; Skaltsounis L; Jove R
    Cancer Biol Ther; 2012 Nov; 13(13):1255-61. PubMed ID: 22895078
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Antitumor activity of a novel STAT3 inhibitor and redox modulator in non-small cell lung cancer cells.
    Liu X; Guo W; Wu S; Wang L; Wang J; Dai B; Kim ES; Heymach JV; Wang M; Girard L; Minna J; Roth JA; Swisher SG; Fang B
    Biochem Pharmacol; 2012 May; 83(10):1456-64. PubMed ID: 22387047
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Targeting the Janus-activated kinase-2-STAT3 signalling pathway in pancreatic cancer using the HSP90 inhibitor ganetespib.
    Nagaraju GP; Mezina A; Shaib WL; Landry J; El-Rayes BF
    Eur J Cancer; 2016 Jan; 52():109-19. PubMed ID: 26682870
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Regulation of Janus-activated kinase-2 (JAK2) by diindolylmethane in ovarian cancer in vitro and in vivo.
    Kandala PK; Srivastava SK
    Drug Discov Ther; 2012 Apr; 6(2):94-101. PubMed ID: 22622019
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A small molecule inhibits Akt through direct binding to Akt and preventing Akt membrane translocation.
    Kim D; Sun M; He L; Zhou QH; Chen J; Sun XM; Bepler G; Sebti SM; Cheng JQ
    J Biol Chem; 2010 Mar; 285(11):8383-94. PubMed ID: 20068047
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Evodiamine inhibits STAT3 signaling by inducing phosphatase shatterproof 1 in hepatocellular carcinoma cells.
    Yang J; Cai X; Lu W; Hu C; Xu X; Yu Q; Cao P
    Cancer Lett; 2013 Jan; 328(2):243-51. PubMed ID: 23032719
    [TBL] [Abstract][Full Text] [Related]  

  • 17. A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells.
    Lin L; Hutzen B; Li PK; Ball S; Zuo M; DeAngelis S; Foust E; Sobo M; Friedman L; Bhasin D; Cen L; Li C; Lin J
    Neoplasia; 2010 Jan; 12(1):39-50. PubMed ID: 20072652
    [TBL] [Abstract][Full Text] [Related]  

  • 18. 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit colon cancer cell and tumor growth through activation of c-jun N-terminal kinase.
    Lei P; Abdelrahim M; Cho SD; Liu S; Chintharlapalli S; Safe S
    Carcinogenesis; 2008 Jun; 29(6):1139-47. PubMed ID: 18460448
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Interruption of RNA processing machinery by a small compound, 1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxaldehyde (oncrasin-1).
    Guo W; Wu S; Wang L; Wang RY; Wei X; Liu J; Fang B
    Mol Cancer Ther; 2009 Feb; 8(2):441-8. PubMed ID: 19208825
    [TBL] [Abstract][Full Text] [Related]  

  • 20. 6-Bromoindirubin-3'-oxime inhibits JAK/STAT3 signaling and induces apoptosis of human melanoma cells.
    Liu L; Nam S; Tian Y; Yang F; Wu J; Wang Y; Scuto A; Polychronopoulos P; Magiatis P; Skaltsounis L; Jove R
    Cancer Res; 2011 Jun; 71(11):3972-9. PubMed ID: 21610112
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.