These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
4. A novel glycine transporter-1 (GlyT1) inhibitor, ASP2535 (4-[3-isopropyl-5-(6-phenyl-3-pyridyl)-4H-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole), improves cognition in animal models of cognitive impairment in schizophrenia and Alzheimer's disease. Harada K; Nakato K; Yarimizu J; Yamazaki M; Morita M; Takahashi S; Aota M; Saita K; Doihara H; Sato Y; Yamaji T; Ni K; Matsuoka N Eur J Pharmacol; 2012 Jun; 685(1-3):59-69. PubMed ID: 22542656 [TBL] [Abstract][Full Text] [Related]
5. Identification of N-(2-(azepan-1-yl)-2-phenylethyl)-benzenesulfonamides as novel inhibitors of GlyT1. Varnes JG; Forst JM; Hoerter TN; Holmquist CR; Wilkins DE; Tian G; Jonak G; Wang X; Potts WM; Wood MW; Alhambra C; Brugel TA; Albert JS Bioorg Med Chem Lett; 2010 Aug; 20(16):4878-81. PubMed ID: 20637614 [TBL] [Abstract][Full Text] [Related]
6. Acylglycinamides as inhibitors of glycine transporter type 1. Blunt R; Porter R; Johns A; Nash D; Puckey G; Wyman P; Herdon H; Teague S; Hadden V; Fontana S; Gordon L Bioorg Med Chem Lett; 2011 Oct; 21(20):6176-9. PubMed ID: 21889344 [TBL] [Abstract][Full Text] [Related]
7. Discovery and SAR studies of novel GlyT1 inhibitors. Walter MW; Hoffman BJ; Gordon K; Johnson K; Love P; Jones M; Man T; Phebus L; Reel JK; Rudyk HC; Shannon H; Svensson K; Yu H; Valli MJ; Porter WJ Bioorg Med Chem Lett; 2007 Sep; 17(18):5233-8. PubMed ID: 17629697 [TBL] [Abstract][Full Text] [Related]
8. Inhibitors of GlyT1 affect glycine transport via discrete binding sites. Mezler M; Hornberger W; Mueller R; Schmidt M; Amberg W; Braje W; Ochse M; Schoemaker H; Behl B Mol Pharmacol; 2008 Dec; 74(6):1705-15. PubMed ID: 18815213 [TBL] [Abstract][Full Text] [Related]
9. Design, synthesis, and in vivo efficacy of glycine transporter-1 (GlyT1) inhibitors derived from a series of [4-phenyl-1-(propylsulfonyl)piperidin-4-yl]methyl benzamides. Lindsley CW; Zhao Z; Leister WH; O'Brien J; Lemaire W; Williams DL; Chen TB; Chang RS; Burno M; Jacobson MA; Sur C; Kinney GG; Pettibone DJ; Tiller PR; Smith S; Tsou NN; Duggan ME; Conn PJ; Hartman GD ChemMedChem; 2006 Aug; 1(8):807-11. PubMed ID: 16902933 [No Abstract] [Full Text] [Related]
10. Glycine transporter (GlyT1) inhibitors with reduced residence time increase prepulse inhibition without inducing hyperlocomotion in DBA/2 mice. Kopec K; Flood DG; Gasior M; McKenna BA; Zuvich E; Schreiber J; Salvino JM; Durkin JT; Ator MA; Marino MJ Biochem Pharmacol; 2010 Nov; 80(9):1407-17. PubMed ID: 20637735 [TBL] [Abstract][Full Text] [Related]
11. The discovery of a structurally novel class of inhibitors of the type 1 glycine transporter. Lowe JA; Hou X; Schmidt C; David Tingley F; McHardy S; Kalman M; Deninno S; Sanner M; Ward K; Lebel L; Tunucci D; Valentine J; Bronk BS; Schaeffer E Bioorg Med Chem Lett; 2009 Jun; 19(11):2974-6. PubMed ID: 19410451 [TBL] [Abstract][Full Text] [Related]
12. Transmembrane domains 1 and 3 of the glycine transporter GLYT1 contain structural determinants of N[3-(4'-fluorophenyl)-3-(4'-phenylphenoxy)-propyl]sarcosine specificity. Núñez E; Martínez-Maza R; Geerlings A; Aragón C; López-Corcuera B Neuropharmacology; 2005 Nov; 49(6):922-34. PubMed ID: 16143353 [TBL] [Abstract][Full Text] [Related]
13. Discovery of N-{[1-(propylsulfonyl)-4-pyridin-2-ylpiperidin-4-yl]methyl}benzamides as novel, selective and potent GlyT1 inhibitors. Zhao Z; Leister WH; O'Brien JA; Lemaire W; Williams DL; Jacobson MA; Sur C; Kinney GG; Pettibone DJ; Tiller PR; Smith S; Hartman GD; Lindsley CW; Wolkenberg SE Bioorg Med Chem Lett; 2009 Mar; 19(5):1488-91. PubMed ID: 19179073 [TBL] [Abstract][Full Text] [Related]
14. Discovery of benzoylpiperazines as a novel class of potent and selective GlyT1 inhibitors. Pinard E; Alberati D; Borroni E; Fischer H; Hainzl D; Jolidon S; Moreau JL; Narquizian R; Nettekoven M; Norcross RD; Stalder H; Thomas AW Bioorg Med Chem Lett; 2008 Sep; 18(18):5134-9. PubMed ID: 18752953 [TBL] [Abstract][Full Text] [Related]
15. Neurochemical and behavioral profiling of the selective GlyT1 inhibitors ALX5407 and LY2365109 indicate a preferential action in caudal vs. cortical brain areas. Perry KW; Falcone JF; Fell MJ; Ryder JW; Yu H; Love PL; Katner J; Gordon KD; Wade MR; Man T; Nomikos GG; Phebus LA; Cauvin AJ; Johnson KW; Jones CK; Hoffmann BJ; Sandusky GE; Walter MW; Porter WJ; Yang L; Merchant KM; Shannon HE; Svensson KA Neuropharmacology; 2008 Oct; 55(5):743-54. PubMed ID: 18602930 [TBL] [Abstract][Full Text] [Related]
16. Synthesis and SAR of GlyT1 inhibitors derived from a series of N-((4-(morpholine-4-carbonyl)-1-(propylsulfonyl)piperidin-4-yl)methyl)benzamides. Zhao Z; O'Brien JA; Lemaire W; Williams DL; Jacobson MA; Sur C; Pettibone DJ; Tiller PR; Smith S; Hartman GD; Wolkenberg SE; Lindsley CW Bioorg Med Chem Lett; 2006 Dec; 16(23):5968-72. PubMed ID: 16987662 [TBL] [Abstract][Full Text] [Related]
17. Discovery of antiglioma activity of biaryl 1,2,3,4-tetrahydroisoquinoline derivatives and conformationally flexible analogues. Mohler ML; Kang GS; Hong SS; Patil R; Kirichenko OV; Li W; Rakov IM; Geisert EE; Miller DD J Med Chem; 2006 Sep; 49(19):5845-8. PubMed ID: 16970409 [TBL] [Abstract][Full Text] [Related]
18. Discovery of N-(2-aryl-cyclohexyl) substituted spiropiperidines as a novel class of GlyT1 inhibitors. Pinard E; Ceccarelli SM; Stalder H; Alberati D Bioorg Med Chem Lett; 2006 Jan; 16(2):349-53. PubMed ID: 16246557 [TBL] [Abstract][Full Text] [Related]
19. Discovery of 4-(benzylaminomethylene)isoquinoline-1,3-(2H,4H)-diones and 4-[(pyridylmethyl)aminomethylene]isoquinoline-1,3-(2H,4H)-diones as potent and selective inhibitors of the cyclin-dependent kinase 4. Tsou HR; Liu X; Birnberg G; Kaplan J; Otteng M; Tran T; Kutterer K; Tang Z; Suayan R; Zask A; Ravi M; Bretz A; Grillo M; McGinnis JP; Rabindran SK; Ayral-Kaloustian S; Mansour TS J Med Chem; 2009 Apr; 52(8):2289-310. PubMed ID: 19317452 [TBL] [Abstract][Full Text] [Related]
20. Design, synthesis, and SAR of N-((1-(4-(propylsulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide inhibitors of glycine transporter-1. Cioffi CL; Wolf MA; Guzzo PR; Sadalapure K; Parthasarathy V; Dethe D; Maeng JH; Carulli E; Loong DT; Fang X; Hu M; Gupta P; Chung M; Bai M; Moore N; Luche M; Khmelnitsky Y; Love PL; Watson MA; Mhyre AJ; Liu S Bioorg Med Chem Lett; 2013 Mar; 23(5):1257-61. PubMed ID: 23380375 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]