BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

294 related articles for article (PubMed ID: 22177953)

  • 1. MEK1/2 dual-specificity protein kinases: structure and regulation.
    Roskoski R
    Biochem Biophys Res Commun; 2012 Jan; 417(1):5-10. PubMed ID: 22177953
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition.
    Ohren JF; Chen H; Pavlovsky A; Whitehead C; Zhang E; Kuffa P; Yan C; McConnell P; Spessard C; Banotai C; Mueller WT; Delaney A; Omer C; Sebolt-Leopold J; Dudley DT; Leung IK; Flamme C; Warmus J; Kaufman M; Barrett S; Tecle H; Hasemann CA
    Nat Struct Mol Biol; 2004 Dec; 11(12):1192-7. PubMed ID: 15543157
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Ribonucleotide reductase small subunit p53R2 suppresses MEK-ERK activity by binding to ERK kinase 2.
    Piao C; Jin M; Kim HB; Lee SM; Amatya PN; Hyun JW; Chang IY; You HJ
    Oncogene; 2009 May; 28(21):2173-84. PubMed ID: 19398949
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Oncogenic tyrosine kinase NPM/ALK induces activation of the MEK/ERK signaling pathway independently of c-Raf.
    Marzec M; Kasprzycka M; Liu X; Raghunath PN; Wlodarski P; Wasik MA
    Oncogene; 2007 Feb; 26(6):813-21. PubMed ID: 16909118
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A full-length 3D structure for MAPK/ERK kinase 2 (MEK2).
    Liang H; Liu T; Chen F; Liu Z; Liu S
    Sci China Life Sci; 2011 Apr; 54(4):336-41. PubMed ID: 21509657
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK.
    Brennan DF; Dar AC; Hertz NT; Chao WC; Burlingame AL; Shokat KM; Barford D
    Nature; 2011 Apr; 472(7343):366-9. PubMed ID: 21441910
    [TBL] [Abstract][Full Text] [Related]  

  • 7. RAF protein-serine/threonine kinases: structure and regulation.
    Roskoski R
    Biochem Biophys Res Commun; 2010 Aug; 399(3):313-7. PubMed ID: 20674547
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Mek1/2 MAPK kinases are essential for Mammalian development, homeostasis, and Raf-induced hyperplasia.
    Scholl FA; Dumesic PA; Barragan DI; Harada K; Bissonauth V; Charron J; Khavari PA
    Dev Cell; 2007 Apr; 12(4):615-29. PubMed ID: 17419998
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Rapid and transient activation of the ERK MAPK signalling pathway by macrophage migration inhibitory factor (MIF) and dependence on JAB1/CSN5 and Src kinase activity.
    Lue H; Kapurniotu A; Fingerle-Rowson G; Roger T; Leng L; Thiele M; Calandra T; Bucala R; Bernhagen J
    Cell Signal; 2006 May; 18(5):688-703. PubMed ID: 16122907
    [TBL] [Abstract][Full Text] [Related]  

  • 10. BRAF-inhibitor Associated MEK Mutations Increase RAF-Dependent and -Independent Enzymatic Activity.
    Emery CM; Monaco KA; Wang P; Balak M; Freeman A; Meltzer J; Delach SM; Rakiec D; Ruddy DA; Korn JM; Haling J; Acker MG; Caponigro G
    Mol Cancer Res; 2017 Oct; 15(10):1431-1444. PubMed ID: 28655712
    [TBL] [Abstract][Full Text] [Related]  

  • 11. RNAi-mediated MEK1 knock-down prevents ERK1/2 activation and abolishes human hepatocarcinoma growth in vitro and in vivo.
    Gailhouste L; Ezan F; Bessard A; Frémin C; Rageul J; Langouët S; Baffet G
    Int J Cancer; 2010 Mar; 126(6):1367-77. PubMed ID: 19816936
    [TBL] [Abstract][Full Text] [Related]  

  • 12. ERK1/2 can feedback-regulate cellular MEK1/2 levels.
    Hong SK; Wu PK; Karkhanis M; Park JI
    Cell Signal; 2015 Oct; 27(10):1939-48. PubMed ID: 26163823
    [TBL] [Abstract][Full Text] [Related]  

  • 13. MAP kinase: it's been longer than fifteen minutes.
    Sturgill TW
    Biochem Biophys Res Commun; 2008 Jun; 371(1):1-4. PubMed ID: 18406346
    [TBL] [Abstract][Full Text] [Related]  

  • 14. MEK1 and MEK2 differentially control the duration and amplitude of the ERK cascade response.
    Kocieniewski P; Lipniacki T
    Phys Biol; 2013 Jun; 10(3):035006. PubMed ID: 23735655
    [TBL] [Abstract][Full Text] [Related]  

  • 15. MEK1 and MEK2 regulate distinct functions by sorting ERK2 to different intracellular compartments.
    Skarpen E; Flinder LI; Rosseland CM; Orstavik S; Wierød L; Oksvold MP; Skålhegg BS; Huitfeldt HS
    FASEB J; 2008 Feb; 22(2):466-76. PubMed ID: 17928366
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Constitutively active MAP kinase kinase (MEK1) stimulates SAP kinase and c-Jun transcriptional activity in U937 human leukemic cells.
    Franklin CC; Kraft AS
    Oncogene; 1995 Dec; 11(11):2365-74. PubMed ID: 8570188
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Biochemistry. KSR plays CRAF-ty.
    Shi F; Lemmon MA
    Science; 2011 May; 332(6033):1043-4. PubMed ID: 21617065
    [No Abstract]   [Full Text] [Related]  

  • 18. MEK drives BRAF activation through allosteric control of KSR proteins.
    Lavoie H; Sahmi M; Maisonneuve P; Marullo SA; Thevakumaran N; Jin T; Kurinov I; Sicheri F; Therrien M
    Nature; 2018 Feb; 554(7693):549-553. PubMed ID: 29433126
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Protein kinase WNK2 inhibits cell proliferation by negatively modulating the activation of MEK1/ERK1/2.
    Moniz S; Veríssimo F; Matos P; Brazão R; Silva E; Kotelevets L; Chastre E; Gespach C; Jordan P
    Oncogene; 2007 Sep; 26(41):6071-81. PubMed ID: 17667937
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Kinase suppressor of RAS (KSR) amplifies the differentiation signal provided by low concentrations 1,25-dihydroxyvitamin D3.
    Wang X; Studzinski GP
    J Cell Physiol; 2004 Mar; 198(3):333-42. PubMed ID: 14755538
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.