294 related articles for article (PubMed ID: 22178553)
1. Tripeptidic BACE1 inhibitors devised by in-silico conformational structure-based design.
Hamada Y; Tagad HD; Nishimura Y; Ishiura S; Kiso Y
Bioorg Med Chem Lett; 2012 Jan; 22(2):1130-5. PubMed ID: 22178553
[TBL] [Abstract][Full Text] [Related]
2. Design of pentapeptidic BACE1 inhibitors with carboxylic acid bioisosteres at P1' and P4 positions.
Tagad HD; Hamada Y; Nguyen JT; Hamada T; Abdel-Rahman H; Yamani A; Nagamine A; Ikari H; Igawa N; Hidaka K; Sohma Y; Kimura T; Kiso Y
Bioorg Med Chem; 2010 May; 18(9):3175-86. PubMed ID: 20381362
[TBL] [Abstract][Full Text] [Related]
3. Novel non-peptidic and small-sized BACE1 inhibitors.
Hamada Y; Ohta H; Miyamoto N; Yamaguchi R; Yamani A; Hidaka K; Kimura T; Saito K; Hayashi Y; Ishiura S; Kiso Y
Bioorg Med Chem Lett; 2008 Mar; 18(5):1643-7. PubMed ID: 18261904
[TBL] [Abstract][Full Text] [Related]
4. Tetrapeptides, as small-sized peptidic inhibitors; synthesis and their inhibitory activity against BACE1.
Kakizawa T; Hidaka K; Hamada D; Yamaguchi R; Uemura T; Kitamura H; Tagad HD; Hamada T; Ziora Z; Hamada Y; Kimura T; Kiso Y
J Pept Sci; 2010 Jun; 16(6):257-62. PubMed ID: 20474036
[TBL] [Abstract][Full Text] [Related]
5. Structure-activity relationship study of BACE1 inhibitors possessing a chelidonic or 2,6-pyridinedicarboxylic scaffold at the P(2) position.
Hamada Y; Suzuki K; Nakanishi T; Sarma D; Ohta H; Yamaguchi R; Yamasaki M; Hidaka K; Ishiura S; Kiso Y
Bioorg Med Chem Lett; 2014 Jan; 24(2):618-23. PubMed ID: 24360554
[TBL] [Abstract][Full Text] [Related]
6. A stereoselective approach to peptidomimetic BACE1 inhibitors.
Butini S; Gabellieri E; Brindisi M; Giovani S; Maramai S; Kshirsagar G; Guarino E; Brogi S; La Pietra V; Giustiniano M; Marinelli L; Novellino E; Campiani G; Cappelli A; Gemma S
Eur J Med Chem; 2013; 70():233-47. PubMed ID: 24158015
[TBL] [Abstract][Full Text] [Related]
7. Novel BACE1 inhibitors possessing a 5-nitroisophthalic scaffold at the P2 position.
Hamada Y; Nakanishi T; Suzuki K; Yamaguchi R; Hamada T; Hidaka K; Ishiura S; Kiso Y
Bioorg Med Chem Lett; 2012 Jul; 22(14):4640-4. PubMed ID: 22726930
[TBL] [Abstract][Full Text] [Related]
8. Significance of interactions of BACE1-Arg235 with its ligands and design of BACE1 inhibitors with P2 pyridine scaffold.
Hamada Y; Ohta H; Miyamoto N; Sarma D; Hamada T; Nakanishi T; Yamasaki M; Yamani A; Ishiura S; Kiso Y
Bioorg Med Chem Lett; 2009 May; 19(9):2435-9. PubMed ID: 19345096
[TBL] [Abstract][Full Text] [Related]
9. Structure-guided design and synthesis of P1' position 1-phenylcycloalkylamine-derived pentapeptidic BACE1 inhibitors.
Tagad HD; Hamada Y; Nguyen JT; Hidaka K; Hamada T; Sohma Y; Kimura T; Kiso Y
Bioorg Med Chem; 2011 Sep; 19(17):5238-46. PubMed ID: 21803585
[TBL] [Abstract][Full Text] [Related]
10. Design and synthesis of potent beta-secretase (BACE1) inhibitors with P1' carboxylic acid bioisosteres.
Kimura T; Hamada Y; Stochaj M; Ikari H; Nagamine A; Abdel-Rahman H; Igawa N; Hidaka K; Nguyen JT; Saito K; Hayashi Y; Kiso Y
Bioorg Med Chem Lett; 2006 May; 16(9):2380-6. PubMed ID: 16481167
[TBL] [Abstract][Full Text] [Related]
11. Design and synthesis of BACE1 inhibitors containing a novel norstatine derivative (2R,3R)-3-amino-2-hydroxy-4-(phenylthio)butyric acid.
Ziora Z; Kasai S; Hidaka K; Nagamine A; Kimura T; Hayashi Y; Kiso Y
Bioorg Med Chem Lett; 2007 Mar; 17(6):1629-33. PubMed ID: 17251016
[TBL] [Abstract][Full Text] [Related]
12. Novel BACE1 inhibitors with a non-acidic heterocycle at the P1' position.
Suzuki K; Hamada Y; Nguyen JT; Kiso Y
Bioorg Med Chem; 2013 Nov; 21(21):6665-73. PubMed ID: 23993670
[TBL] [Abstract][Full Text] [Related]
13. New pyrazolyl and thienyl aminohydantoins as potent BACE1 inhibitors: exploring the S2' region.
Malamas MS; Erdei J; Gunawan I; Barnes K; Hui Y; Johnson M; Robichaud A; Zhou P; Yan Y; Solvibile W; Turner J; Fan KY; Chopra R; Bard J; Pangalos MN
Bioorg Med Chem Lett; 2011 Sep; 21(18):5164-70. PubMed ID: 21835615
[TBL] [Abstract][Full Text] [Related]
14. From fragment screening to in vivo efficacy: optimization of a series of 2-aminoquinolines as potent inhibitors of beta-site amyloid precursor protein cleaving enzyme 1 (BACE1).
Cheng Y; Judd TC; Bartberger MD; Brown J; Chen K; Fremeau RT; Hickman D; Hitchcock SA; Jordan B; Li V; Lopez P; Louie SW; Luo Y; Michelsen K; Nixey T; Powers TS; Rattan C; Sickmier EA; St Jean DJ; Wahl RC; Wen PH; Wood S
J Med Chem; 2011 Aug; 54(16):5836-57. PubMed ID: 21707077
[TBL] [Abstract][Full Text] [Related]
15. BACE1 inhibitors: optimization by replacing the P1' residue with non-acidic moiety.
Hamada Y; Abdel-Rahman H; Yamani A; Nguyen JT; Stochaj M; Hidaka K; Kimura T; Hayashi Y; Saito K; Ishiura S; Kiso Y
Bioorg Med Chem Lett; 2008 Mar; 18(5):1649-53. PubMed ID: 18249539
[TBL] [Abstract][Full Text] [Related]
16. Structure based design of iminohydantoin BACE1 inhibitors: identification of an orally available, centrally active BACE1 inhibitor.
Cumming JN; Smith EM; Wang L; Misiaszek J; Durkin J; Pan J; Iserloh U; Wu Y; Zhu Z; Strickland C; Voigt J; Chen X; Kennedy ME; Kuvelkar R; Hyde LA; Cox K; Favreau L; Czarniecki MF; Greenlee WJ; McKittrick BA; Parker EM; Stamford AW
Bioorg Med Chem Lett; 2012 Apr; 22(7):2444-9. PubMed ID: 22390835
[TBL] [Abstract][Full Text] [Related]
17. Conformational restriction approach to BACE1 inhibitors II: SAR study of the isocytosine derivatives fixed with a cis-cyclopropane ring.
Yonezawa S; Yamakawa H; Muto C; Hosono M; Yamamoto T; Hattori K; Sakagami M; Togame H; Tanaka Y; Nakano T; Takemoto H; Arisawa M; Shuto S
Bioorg Med Chem Lett; 2013 May; 23(10):2912-5. PubMed ID: 23562056
[TBL] [Abstract][Full Text] [Related]
18. Thiophene substituted acylguanidines as BACE1 inhibitors.
Fobare WF; Solvibile WR; Robichaud AJ; Malamas MS; Manas E; Turner J; Hu Y; Wagner E; Chopra R; Cowling R; Jin G; Bard J
Bioorg Med Chem Lett; 2007 Oct; 17(19):5353-6. PubMed ID: 17761418
[TBL] [Abstract][Full Text] [Related]
19. Design, synthesis and biological evaluation of tasiamide B derivatives as BACE1 inhibitors.
Liu J; Chen W; Xu Y; Ren S; Zhang W; Li Y
Bioorg Med Chem; 2015 May; 23(9):1963-74. PubMed ID: 25842365
[TBL] [Abstract][Full Text] [Related]
20. P-glycoprotein efflux and other factors limit brain amyloid beta reduction by beta-site amyloid precursor protein-cleaving enzyme 1 inhibitors in mice.
Meredith JE; Thompson LA; Toyn JH; Marcin L; Barten DM; Marcinkeviciene J; Kopcho L; Kim Y; Lin A; Guss V; Burton C; Iben L; Polson C; Cantone J; Ford M; Drexler D; Fiedler T; Lentz KA; Grace JE; Kolb J; Corsa J; Pierdomenico M; Jones K; Olson RE; Macor JE; Albright CF
J Pharmacol Exp Ther; 2008 Aug; 326(2):502-13. PubMed ID: 18499745
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
