BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

396 related articles for article (PubMed ID: 22195962)

  • 1. Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism.
    Hitosugi T; Fan J; Chung TW; Lythgoe K; Wang X; Xie J; Ge Q; Gu TL; Polakiewicz RD; Roesel JL; Chen GZ; Boggon TJ; Lonial S; Fu H; Khuri FR; Kang S; Chen J
    Mol Cell; 2011 Dec; 44(6):864-77. PubMed ID: 22195962
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Tyr-301 phosphorylation inhibits pyruvate dehydrogenase by blocking substrate binding and promotes the Warburg effect.
    Fan J; Kang HB; Shan C; Elf S; Lin R; Xie J; Gu TL; Aguiar M; Lonning S; Chung TW; Arellano M; Khoury HJ; Shin DM; Khuri FR; Boggon TJ; Kang S; Chen J
    J Biol Chem; 2014 Sep; 289(38):26533-26541. PubMed ID: 25104357
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Tyr-94 phosphorylation inhibits pyruvate dehydrogenase phosphatase 1 and promotes tumor growth.
    Shan C; Kang HB; Elf S; Xie J; Gu TL; Aguiar M; Lonning S; Hitosugi T; Chung TW; Arellano M; Khoury HJ; Shin DM; Khuri FR; Boggon TJ; Fan J
    J Biol Chem; 2014 Aug; 289(31):21413-22. PubMed ID: 24962578
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis.
    Li X; Jiang Y; Meisenhelder J; Yang W; Hawke DH; Zheng Y; Xia Y; Aldape K; He J; Hunter T; Wang L; Lu Z
    Mol Cell; 2016 Mar; 61(5):705-719. PubMed ID: 26942675
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Tyrosine phosphorylation of lactate dehydrogenase A is important for NADH/NAD(+) redox homeostasis in cancer cells.
    Fan J; Hitosugi T; Chung TW; Xie J; Ge Q; Gu TL; Polakiewicz RD; Chen GZ; Boggon TJ; Lonial S; Khuri FR; Kang S; Chen J
    Mol Cell Biol; 2011 Dec; 31(24):4938-50. PubMed ID: 21969607
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex.
    Fan J; Shan C; Kang HB; Elf S; Xie J; Tucker M; Gu TL; Aguiar M; Lonning S; Chen H; Mohammadi M; Britton LM; Garcia BA; Alečković M; Kang Y; Kaluz S; Devi N; Van Meir EG; Hitosugi T; Seo JH; Lonial S; Gaddh M; Arellano M; Khoury HJ; Khuri FR; Boggon TJ; Kang S; Chen J
    Mol Cell; 2014 Feb; 53(4):534-48. PubMed ID: 24486017
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Src drives the Warburg effect and therapy resistance by inactivating pyruvate dehydrogenase through tyrosine-289 phosphorylation.
    Jin Y; Cai Q; Shenoy AK; Lim S; Zhang Y; Charles S; Tarrash M; Fu X; Kamarajugadda S; Trevino JG; Tan M; Lu J
    Oncotarget; 2016 May; 7(18):25113-24. PubMed ID: 26848621
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Microenvironmental control of glucose metabolism in tumors by regulation of pyruvate dehydrogenase.
    Golias T; Kery M; Radenkovic S; Papandreou I
    Int J Cancer; 2019 Feb; 144(4):674-686. PubMed ID: 30121950
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Targeting pyruvate dehydrogenase kinase signaling in the development of effective cancer therapy.
    Anwar S; Shamsi A; Mohammad T; Islam A; Hassan MI
    Biochim Biophys Acta Rev Cancer; 2021 Aug; 1876(1):188568. PubMed ID: 34023419
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Tetrameric Acetyl-CoA Acetyltransferase 1 Is Important for Tumor Growth.
    Fan J; Lin R; Xia S; Chen D; Elf SE; Liu S; Pan Y; Xu H; Qian Z; Wang M; Shan C; Zhou L; Lei QY; Li Y; Mao H; Lee BH; Sudderth J; DeBerardinis RJ; Zhang G; Owonikoko T; Gaddh M; Arellano ML; Khoury HJ; Khuri FR; Kang S; Doetsch PW; Lonial S; Boggon TJ; Curran WJ; Chen J
    Mol Cell; 2016 Dec; 64(5):859-874. PubMed ID: 27867011
    [TBL] [Abstract][Full Text] [Related]  

  • 11. A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence.
    Kaplon J; Zheng L; Meissl K; Chaneton B; Selivanov VA; Mackay G; van der Burg SH; Verdegaal EM; Cascante M; Shlomi T; Gottlieb E; Peeper DS
    Nature; 2013 Jun; 498(7452):109-12. PubMed ID: 23685455
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Metabolic reorganization in winter: Regulation of pyruvate dehydrogenase (PDH) during long-term freezing and anoxia.
    Al-Attar R; Wijenayake S; Storey KB
    Cryobiology; 2019 Feb; 86():10-18. PubMed ID: 30639451
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth.
    Hitosugi T; Kang S; Vander Heiden MG; Chung TW; Elf S; Lythgoe K; Dong S; Lonial S; Wang X; Chen GZ; Xie J; Gu TL; Polakiewicz RD; Roesel JL; Boggon TJ; Khuri FR; Gilliland DG; Cantley LC; Kaufman J; Chen J
    Sci Signal; 2009 Nov; 2(97):ra73. PubMed ID: 19920251
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Vitamin C activates pyruvate dehydrogenase (PDH) targeting the mitochondrial tricarboxylic acid (TCA) cycle in hypoxic
    Cenigaonandia-Campillo A; Serna-Blasco R; Gómez-Ocabo L; Solanes-Casado S; Baños-Herraiz N; Puerto-Nevado LD; Cañas JA; Aceñero MJ; García-Foncillas J; Aguilera Ó
    Theranostics; 2021; 11(8):3595-3606. PubMed ID: 33664850
    [No Abstract]   [Full Text] [Related]  

  • 15. Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer.
    Stacpoole PW
    J Natl Cancer Inst; 2017 Nov; 109(11):. PubMed ID: 29059435
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers.
    Chatterjee N; Pazarentzos E; Mayekar MK; Gui P; Allegakoen DV; Hrustanovic G; Olivas V; Lin L; Verschueren E; Johnson JR; Hofree M; Yan JJ; Newton BW; Dollen JV; Earnshaw CH; Flanagan J; Chan E; Asthana S; Ideker T; Wu W; Suzuki J; Barad BA; Kirichok Y; Fraser JS; Weiss WA; Krogan NJ; Tulpule A; Sabnis AJ; Bivona TG
    Cell Rep; 2019 Aug; 28(9):2317-2330.e8. PubMed ID: 31461649
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Mitochondrial mutations contribute to HIF1alpha accumulation via increased reactive oxygen species and up-regulated pyruvate dehydrogenease kinase 2 in head and neck squamous cell carcinoma.
    Sun W; Zhou S; Chang SS; McFate T; Verma A; Califano JA
    Clin Cancer Res; 2009 Jan; 15(2):476-84. PubMed ID: 19147752
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Dynamic regulation of mitochondrial pyruvate metabolism is necessary for orthotopic pancreatic tumor growth.
    Echeverri Ruiz NP; Mohan V; Wu J; Scott S; Kreamer M; Benej M; Golias T; Papandreou I; Denko NC
    Cancer Metab; 2021 Nov; 9(1):39. PubMed ID: 34749809
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Ilimaquinone Induces the Apoptotic Cell Death of Cancer Cells by Reducing Pyruvate Dehydrogenase Kinase 1 Activity.
    Kwak CH; Jin L; Han JH; Han CW; Kim E; Cho M; Chung TW; Bae SJ; Jang SB; Ha KT
    Int J Mol Sci; 2020 Aug; 21(17):. PubMed ID: 32825675
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Phosphorylation of the pyruvate dehydrogenase complex precedes HIF-1-mediated effects and pyruvate dehydrogenase kinase 1 upregulation during the first hours of hypoxic treatment in hepatocellular carcinoma cells.
    Zimmer AD; Walbrecq G; Kozar I; Behrmann I; Haan C
    Hypoxia (Auckl); 2016; 4():135-145. PubMed ID: 27800515
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 20.