135 related articles for article (PubMed ID: 22197136)
1. Synthesis and structure-activity relationship of 5-pyridazin-3-one phenoxypiperidines as potent, selective histamine H(3) receptor inverse agonists.
Tao M; Aimone LD; Gruner JA; Mathiasen JR; Huang Z; Lyons J; Raddatz R; Hudkins RL
Bioorg Med Chem Lett; 2012 Jan; 22(2):1073-7. PubMed ID: 22197136
[TBL] [Abstract][Full Text] [Related]
2. Optimization of 5-pyridazin-3-one phenoxypropylamines as potent, selective histamine H₃ receptor antagonists with potent cognition enhancing activity.
Tao M; Aimone LD; Huang Z; Mathiasen J; Raddatz R; Lyons J; Hudkins RL
J Med Chem; 2012 Jan; 55(1):414-23. PubMed ID: 22107017
[TBL] [Abstract][Full Text] [Related]
3. 4-phenoxypiperidine pyridazin-3-one histamine H(3) receptor inverse agonists demonstrating potent and robust wake promoting activity.
Hudkins RL; Zulli AL; Dandu Rr; Tao M; Josef KA; Aimone LD; Haltiwanger RC; Huang Z; Lyons JA; Mathiasen JR; Raddatz R; Gruner JA
Bioorg Med Chem Lett; 2012 Feb; 22(4):1504-9. PubMed ID: 22290075
[TBL] [Abstract][Full Text] [Related]
4. Identification of pyridazin-3-one derivatives as potent, selective histamine H₃ receptor inverse agonists with robust wake activity.
Hudkins RL; Aimone LD; Bailey TR; Bendesky RJ; Dandu RR; Dunn D; Gruner JA; Josef KA; Lin YG; Lyons J; Marcy VR; Mathiasen JR; Sundar BG; Tao M; Zulli AL; Raddatz R; Bacon ER
Bioorg Med Chem Lett; 2011 Sep; 21(18):5493-7. PubMed ID: 21782432
[TBL] [Abstract][Full Text] [Related]
5. 4,5-dihydropyridazin-3-one derivatives as histamine H₃ receptor inverse agonists.
Hudkins RL; Aimone LD; Dandu RR; Dunn D; Gruner JA; Huang Z; Josef KA; Lyons JA; Mathiasen JR; Tao M; Zulli AL; Raddatz R
Bioorg Med Chem Lett; 2012 Jan; 22(1):194-8. PubMed ID: 22142542
[TBL] [Abstract][Full Text] [Related]
6. Synthesis and evaluation of 4- and 5-pyridazin-3-one phenoxypropylamine analogues as histamine-3 receptor antagonists.
Becknell NC; Lyons JA; Aimone LD; Huang Z; Gruner JA; Raddatz R; Hudkins RL
Bioorg Med Chem; 2012 Jun; 20(12):3880-6. PubMed ID: 22578490
[TBL] [Abstract][Full Text] [Related]
7. Discovery of (1R,6S)-5-[4-(1-cyclobutyl-piperidin-4-yloxy)-phenyl]-3,4-diaza-bicyclo[4.1.0]hept-4-en-2-one (R,S-4a): histamine H(3) receptor inverse agonist demonstrating potent cognitive enhancing and wake promoting activity.
Hudkins RL; Josef KA; Becknell NC; Aimone LD; Lyons JA; Mathiasen JR; Gruner JA; Raddatz R
Bioorg Med Chem Lett; 2014 Mar; 24(5):1303-6. PubMed ID: 24513042
[TBL] [Abstract][Full Text] [Related]
8. Synthesis and structure-activity relationships of 4,5-fused pyridazinones as histamine H₃ receptor antagonists.
Tao M; Raddatz R; Aimone LD; Hudkins RL
Bioorg Med Chem Lett; 2011 Oct; 21(20):6126-30. PubMed ID: 21906941
[TBL] [Abstract][Full Text] [Related]
9. Discovery and characterization of 6-{4-[3-(R)-2-methylpyrrolidin-1-yl)propoxy]phenyl}-2H-pyridazin-3-one (CEP-26401, irdabisant): a potent, selective histamine H3 receptor inverse agonist.
Hudkins RL; Raddatz R; Tao M; Mathiasen JR; Aimone LD; Becknell NC; Prouty CP; Knutsen LJ; Yazdanian M; Moachon G; Ator MA; Mallamo JP; Marino MJ; Bacon ER; Williams M
J Med Chem; 2011 Jul; 54(13):4781-92. PubMed ID: 21634396
[TBL] [Abstract][Full Text] [Related]
10. 4-phenoxypiperidines: potent, conformationally restricted, non-imidazole histamine H3 antagonists.
Dvorak CA; Apodaca R; Barbier AJ; Berridge CW; Wilson SJ; Boggs JD; Xiao W; Lovenberg TW; Carruthers NI
J Med Chem; 2005 Mar; 48(6):2229-38. PubMed ID: 15771465
[TBL] [Abstract][Full Text] [Related]
11. Synthesis and evaluation of pyridone-phenoxypropyl-R-2-methylpyrrolidine analogues as histamine H3 receptor antagonists.
Becknell NC; Lyons JA; Aimone LD; Gruner JA; Mathiasen JR; Raddatz R; Hudkins RL
Bioorg Med Chem Lett; 2011 Dec; 21(23):7076-80. PubMed ID: 22014551
[TBL] [Abstract][Full Text] [Related]
12. Amine-constrained pyridazinone histamine H₃ receptor antagonists.
Sundar BG; Bailey T; Bacon E; Aimone L; Huang Z; Lyons J; Raddatz R; Hudkins R
Bioorg Med Chem Lett; 2011 Sep; 21(18):5543-6. PubMed ID: 21824776
[TBL] [Abstract][Full Text] [Related]
13. Discovery of potent and selective histamine H3 receptor inverse agonists based on the 3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one scaffold.
Richter HG; Freichel C; Huwyler J; Nakagawa T; Nettekoven M; Plancher JM; Raab S; Roche O; Schuler F; Taylor S; Ullmer C; Wiegand R
Bioorg Med Chem Lett; 2010 Oct; 20(19):5713-7. PubMed ID: 20801030
[TBL] [Abstract][Full Text] [Related]
14. 3,4-Diaza-bicyclo[4.1.0]hept-4-en-2-one phenoxypropylamine analogs of irdabisant (CEP-26401) as potent histamine-3 receptor inverse agonists with robust wake-promoting activity.
Hudkins RL; Becknell NC; Lyons JA; Aimone LD; Olsen M; Haltiwanger RC; Mathiasen JR; Raddatz R; Gruner JA
Eur J Med Chem; 2015 May; 95():349-56. PubMed ID: 25827402
[TBL] [Abstract][Full Text] [Related]
15. Pharmacological properties and procognitive effects of ABT-288, a potent and selective histamine H3 receptor antagonist.
Esbenshade TA; Browman KE; Miller TR; Krueger KM; Komater-Roderwald V; Zhang M; Fox GB; Rueter L; Robb HM; Radek RJ; Drescher KU; Fey TA; Bitner RS; Marsh K; Polakowski JS; Zhao C; Cowart MD; Hancock AA; Sullivan JP; Brioni JD
J Pharmacol Exp Ther; 2012 Oct; 343(1):233-45. PubMed ID: 22815533
[TBL] [Abstract][Full Text] [Related]
16. Synthesis of constrained benzocinnolinone analogues of CEP-26401 (irdabisant) as potent, selective histamine H3 receptor inverse agonists.
Josef KA; Aimone LD; Lyons J; Raddatz R; Hudkins RL
Bioorg Med Chem Lett; 2012 Jun; 22(12):4198-202. PubMed ID: 22617490
[TBL] [Abstract][Full Text] [Related]
17. Pharmacological characterization of A-960656, a histamine H₃ receptor antagonist with efficacy in animal models of osteoarthritis and neuropathic pain.
Cowart M; Hsieh G; Black LA; Zhan C; Gomez EJ; Pai M; Strakhova M; Manelli A; Carr T; Wetter J; Lee A; Diaz G; Garrison T; Brioni JD
Eur J Pharmacol; 2012 Jun; 684(1-3):87-94. PubMed ID: 22504024
[TBL] [Abstract][Full Text] [Related]
18. Novel morpholine ketone analogs as potent histamine H3 receptor inverse agonists with wake activity.
Sundar BG; Bailey TR; Dunn D; Hostetler GA; Chatterjee S; Bacon ER; Yue C; Schweizer D; Aimone LD; Gruner JA; Lyons J; Raddatz R; Lesur B
Bioorg Med Chem Lett; 2012 Feb; 22(4):1546-9. PubMed ID: 22297111
[TBL] [Abstract][Full Text] [Related]
19. Diether derivatives of homo- or substituted piperidines as non-imidazole histamine H3 receptor ligands.
Łazewska D; Kuder K; Ligneau X; Camelin JC; Schunack W; Stark H; Kieć-Kononowicz K
Bioorg Med Chem; 2009 Apr; 17(8):3037-42. PubMed ID: 19329325
[TBL] [Abstract][Full Text] [Related]
20. Pharmacological and behavioral properties of A-349821, a selective and potent human histamine H3 receptor antagonist.
Esbenshade TA; Fox GB; Krueger KM; Baranowski JL; Miller TR; Kang CH; Denny LI; Witte DG; Yao BB; Pan JB; Faghih R; Bennani YL; Williams M; Hancock AA
Biochem Pharmacol; 2004 Sep; 68(5):933-45. PubMed ID: 15294456
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
