BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

110 related articles for article (PubMed ID: 22197390)

  • 1. The discovery of potent antagonists of NPBWR1 (GPR7).
    Anthony Romero F; Hastings NB; Moningka R; Guo Z; Wang M; Di Salvo J; Lei Y; Trusca D; Deng Q; Tong V; Terebetski JL; Ball RG; Ujjainwalla F
    Bioorg Med Chem Lett; 2012 Jan; 22(2):1014-8. PubMed ID: 22197390
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Pharmacological and pharmacokinetic characterization of 2-piperazine-alpha-isopropyl benzylamine derivatives as melanocortin-4 receptor antagonists.
    Chen C; Tucci FC; Jiang W; Tran JA; Fleck BA; Hoare SR; Wen J; Chen T; Johns M; Markison S; Foster AC; Marinkovic D; Chen CW; Arellano M; Harman J; Saunders J; Bozigian H; Marks D
    Bioorg Med Chem; 2008 May; 16(10):5606-18. PubMed ID: 18417348
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Discovery process and pharmacological characterization of a novel dual orexin 1 and orexin 2 receptor antagonist useful for treatment of sleep disorders.
    Di Fabio R; Pellacani A; Faedo S; Roth A; Piccoli L; Gerrard P; Porter RA; Johnson CN; Thewlis K; Donati D; Stasi L; Spada S; Stemp G; Nash D; Branch C; Kindon L; Massagrande M; Poffe A; Braggio S; Chiarparin E; Marchioro C; Ratti E; Corsi M
    Bioorg Med Chem Lett; 2011 Sep; 21(18):5562-7. PubMed ID: 21831639
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Synthesis and structure-activity relationships of indole and benzimidazole piperazines as histamine H(4) receptor antagonists.
    Terzioglu N; van Rijn RM; Bakker RA; De Esch IJ; Leurs R
    Bioorg Med Chem Lett; 2004 Nov; 14(21):5251-6. PubMed ID: 15454206
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Design, synthesis and SAR analysis of novel potent and selective small molecule antagonists of NPBWR1 (GPR7).
    Urbano M; Guerrero M; Zhao J; Velaparthi S; Saldanha SA; Chase P; Wang Z; Civelli O; Hodder P; Schaeffer MT; Brown S; Rosen H; Roberts E
    Bioorg Med Chem Lett; 2012 Dec; 22(23):7135-41. PubMed ID: 23079522
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Deconstruction of sulfonamide inhibitors of the urotensin receptor (UT) and design and synthesis of benzylamine and benzylsulfone antagonists.
    Taylor SJ; Soleymanzadeh F; Muegge I; Akiba I; Taki N; Ueda S; Mainolfi E; Eldrup AB
    Bioorg Med Chem Lett; 2013 Apr; 23(7):2177-80. PubMed ID: 23453841
    [TBL] [Abstract][Full Text] [Related]  

  • 7. SAR analysis of novel non-peptidic NPBWR1 (GPR7) antagonists.
    Guerrero M; Urbano M; Schaeffer MT; Brown S; Rosen H; Roberts E
    Bioorg Med Chem Lett; 2013 Feb; 23(3):614-9. PubMed ID: 23287738
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis of novel histamine H4 receptor antagonists.
    Lane CA; Hay D; Mowbray CE; Paradowski M; Selby MD; Swain NA; Williams DH
    Bioorg Med Chem Lett; 2012 Jan; 22(2):1156-9. PubMed ID: 22189138
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Fragment-based lead discovery of a novel class of small molecule antagonists of neuropeptide B/W receptor subtype 1 (GPR7).
    Moningka R; Romero FA; Hastings NB; Guo Z; Wang M; Di Salvo J; Li Y; Trusca D; Deng Q; Tong V; Terebetski JL; Ball RG; Ujjainwalla F
    Bioorg Med Chem Lett; 2020 Dec; 30(23):127510. PubMed ID: 32898693
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discovery of ((1S,3R)-1-isopropyl-3-((3S,4S)-3-methoxy-tetrahydro-2H-pyran-4-ylamino)cyclopentyl)(4-(5-(trifluoromethyl)pyridazin-3-yl)piperazin-1-yl)methanone, PF-4254196, a CCR2 antagonist with an improved cardiovascular profile.
    Hughes RO; Rogier DJ; Devraj R; Zheng C; Cao G; Feng H; Xia M; Anand R; Xing L; Glenn J; Zhang K; Covington M; Morton PA; Hutzler JM; Davis JW; Scherle P; Baribaud F; Bahinski A; Mo ZL; Newton R; Metcalf B; Xue CB
    Bioorg Med Chem Lett; 2011 May; 21(9):2626-30. PubMed ID: 21315584
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Computational insights into the binding mechanism of antagonists with neuropeptide B/W receptor 1.
    Patra MC; Maharana J; Dehury B; De S
    Mol Biosyst; 2014 Aug; 10(8):2236-46. PubMed ID: 24938207
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Piperazinebenzylamines as potent and selective antagonists of the human melanocortin-4 receptor.
    Pontillo J; Tran JA; Fleck BA; Marinkovic D; Arellano M; Tucci FC; Lanier M; Nelson J; Parker J; Saunders J; Murphy B; Foster AC; Chen C
    Bioorg Med Chem Lett; 2004 Nov; 14(22):5605-9. PubMed ID: 15482933
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Design, synthesis, in vitro, and in vivo characterization of phenylpiperazines and pyridinylpiperazines as potent and selective antagonists of the melanocortin-4 receptor.
    Tran JA; Jiang W; Tucci FC; Fleck BA; Wen J; Sai Y; Madan A; Chen TK; Markison S; Foster AC; Hoare SR; Marks D; Harman J; Chen CW; Arellano M; Marinkovic D; Bozigian H; Saunders J; Chen C
    J Med Chem; 2007 Dec; 50(25):6356-66. PubMed ID: 17994683
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Discovery and initial SAR of arylsulfonylpiperazine inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1).
    Sun D; Wang Z; Di Y; Jaen JC; Labelle M; Ma J; Miao S; Sudom A; Tang L; Tomooka CS; Tu H; Ursu S; Walker N; Yan X; Ye Q; Powers JP
    Bioorg Med Chem Lett; 2008 Jun; 18(12):3513-6. PubMed ID: 18511278
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists.
    Venable JD; Cai H; Chai W; Dvorak CA; Grice CA; Jablonowski JA; Shah CR; Kwok AK; Ly KS; Pio B; Wei J; Desai PJ; Jiang W; Nguyen S; Ling P; Wilson SJ; Dunford PJ; Thurmond RL; Lovenberg TW; Karlsson L; Carruthers NI; Edwards JP
    J Med Chem; 2005 Dec; 48(26):8289-98. PubMed ID: 16366610
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Discovery of [(2R,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): a dual orexin receptor antagonist with potent sleep-promoting properties.
    Coleman PJ; Schreier JD; Cox CD; Breslin MJ; Whitman DB; Bogusky MJ; McGaughey GB; Bednar RA; Lemaire W; Doran SM; Fox SV; Garson SL; Gotter AL; Harrell CM; Reiss DR; Cabalu TD; Cui D; Prueksaritanont T; Stevens J; Tannenbaum PL; Ball RG; Stellabott J; Young SD; Hartman GD; Winrow CJ; Renger JJ
    ChemMedChem; 2012 Mar; 7(3):415-24, 337. PubMed ID: 22307992
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synthesis and biological evaluation of benzodioxanylpiperazine derivatives as potent serotonin 5-HT(1A) antagonists: the discovery of Lecozotan.
    Childers WE; Abou-Gharbia MA; Kelly MG; Andree TH; Harrison BL; Ho DM; Hornby G; Huryn DM; Potestio L; Rosenzweig-Lipson SJ; Schmid J; Smith DL; Sukoff SJ; Zhang G; Schechter LE
    J Med Chem; 2005 May; 48(10):3467-70. PubMed ID: 15887953
    [TBL] [Abstract][Full Text] [Related]  

  • 18. N-(2-alkylaminoethyl)-4-(1,2,4-oxadiazol-5-yl)piperazine-1-carboxamides as highly potent smoothened antagonists.
    Muraglia E; Ontoria JM; Branca D; Dessole G; Bresciani A; Fonsi M; Giuliano C; Llauger Bufi L; Monteagudo E; Palumbi MC; Torrisi C; Rowley M; Steinkühler C; Jones P
    Bioorg Med Chem Lett; 2011 Sep; 21(18):5283-8. PubMed ID: 21802943
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis and structure-activity relationship of fluoro analogues of 8-{2-[4-(4-methoxyphenyl)piperazin-1yl]ethyl}-8-azaspiro[4.5]decane-7,9-dione as selective alpha(1d)-adrenergic receptor antagonists.
    Konkel MJ; Wetzel JM; Cahir M; Craig DA; Noble SA; Gluchowski C
    J Med Chem; 2005 Apr; 48(8):3076-9. PubMed ID: 15828846
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis, structure-activity relationship studies, and identification of novel 5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine derivatives as dual orexin receptor antagonists. Part 1.
    Sifferlen T; Koberstein R; Cottreel E; Boller A; Weller T; Gatfield J; Brisbare-Roch C; Jenck F; Boss C
    Bioorg Med Chem Lett; 2013 Apr; 23(7):2212-6. PubMed ID: 23434414
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.