268 related articles for article (PubMed ID: 22197397)
1. Pyridobenzothiazole derivatives as new chemotype targeting the HCV NS5B polymerase.
Manfroni G; Meschini F; Barreca ML; Leyssen P; Samuele A; Iraci N; Sabatini S; Massari S; Maga G; Neyts J; Cecchetti V
Bioorg Med Chem; 2012 Jan; 20(2):866-76. PubMed ID: 22197397
[TBL] [Abstract][Full Text] [Related]
2. Quinolones as HCV NS5B polymerase inhibitors.
Kumar DV; Rai R; Brameld KA; Somoza JR; Rajagopalan R; Janc JW; Xia YM; Ton TL; Shaghafi MB; Hu H; Lehoux I; To N; Young WB; Green MJ
Bioorg Med Chem Lett; 2011 Jan; 21(1):82-7. PubMed ID: 21145235
[TBL] [Abstract][Full Text] [Related]
3. Structure-based virtual screening, synthesis and SAR of novel inhibitors of hepatitis C virus NS5B polymerase.
Talele TT; Arora P; Kulkarni SS; Patel MR; Singh S; Chudayeu M; Kaushik-Basu N
Bioorg Med Chem; 2010 Jul; 18(13):4630-8. PubMed ID: 20627595
[TBL] [Abstract][Full Text] [Related]
4. Tri-substituted acylhydrazines as tertiary amide bioisosteres: HCV NS5B polymerase inhibitors.
Canales E; Carlson JS; Appleby T; Fenaux M; Lee J; Tian Y; Tirunagari N; Wong M; Watkins WJ
Bioorg Med Chem Lett; 2012 Jul; 22(13):4288-92. PubMed ID: 22664130
[TBL] [Abstract][Full Text] [Related]
5. Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors.
Stammers TA; Coulombe R; Rancourt J; Thavonekham B; Fazal G; Goulet S; Jakalian A; Wernic D; Tsantrizos Y; Poupart MA; Bös M; McKercher G; Thauvette L; Kukolj G; Beaulieu PL
Bioorg Med Chem Lett; 2013 May; 23(9):2585-9. PubMed ID: 23545108
[TBL] [Abstract][Full Text] [Related]
6. Anthranilic acid-based Thumb Pocket 2 HCV NS5B polymerase inhibitors with sub-micromolar potency in the cell-based replicon assay.
Stammers TA; Coulombe R; Duplessis M; Fazal G; Gagnon A; Garneau M; Goulet S; Jakalian A; LaPlante S; Rancourt J; Thavonekham B; Wernic D; Kukolj G; Beaulieu PL
Bioorg Med Chem Lett; 2013 Dec; 23(24):6879-85. PubMed ID: 24176401
[TBL] [Abstract][Full Text] [Related]
7. Cyclic amide bioisosterism: strategic application to the design and synthesis of HCV NS5B polymerase inhibitors.
Yang H; Hendricks RT; Arora N; Nitzan D; Yee C; Lucas MC; Yang Y; Fung A; Rajyaguru S; Harris SF; Leveque VJ; Hang JQ; Pogam SL; Reuter D; Tavares GA
Bioorg Med Chem Lett; 2010 Aug; 20(15):4614-9. PubMed ID: 20584604
[TBL] [Abstract][Full Text] [Related]
8. Allosteric inhibitors of hepatitis C virus NS5B polymerase thumb domain site II: structure-based design and synthesis of new templates.
Malancona S; Donghi M; Ferrara M; Martin Hernando JI; Pompei M; Pesci S; Ontoria JM; Koch U; Rowley M; Summa V
Bioorg Med Chem; 2010 Apr; 18(8):2836-48. PubMed ID: 20363140
[TBL] [Abstract][Full Text] [Related]
9. Novel 4-thiazolidinones as non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA polymerase.
Çakir G; Küçükgüzel İ; Guhamazumder R; Tatar E; Manvar D; Basu A; Patel BA; Zia J; Talele TT; Kaushik-Basu N
Arch Pharm (Weinheim); 2015 Jan; 348(1):10-22. PubMed ID: 25449674
[TBL] [Abstract][Full Text] [Related]
10. Recent advances on the synthesis of hepatitis C virus NS5B RNA-dependent RNA-polymerase inhibitors.
Zhao C; Wang Y; Ma S
Eur J Med Chem; 2015 Sep; 102():188-214. PubMed ID: 26276434
[TBL] [Abstract][Full Text] [Related]
11. The design, synthesis and biological evaluations of C-6 or C-7 substituted 2-hydroxyisoquinoline-1,3-diones as inhibitors of hepatitis C virus.
Chen YL; Tang J; Kesler MJ; Sham YY; Vince R; Geraghty RJ; Wang Z
Bioorg Med Chem; 2012 Jan; 20(1):467-79. PubMed ID: 22100256
[TBL] [Abstract][Full Text] [Related]
12. 2-Heteroarylimino-5-arylidene-4-thiazolidinones as a new class of non-nucleoside inhibitors of HCV NS5B polymerase.
Küçükgüzel I; Satılmış G; Gurukumar KR; Basu A; Tatar E; Nichols DB; Talele TT; Kaushik-Basu N
Eur J Med Chem; 2013 Nov; 69():931-41. PubMed ID: 24161679
[TBL] [Abstract][Full Text] [Related]
13. Discovery of novel Hepatitis C virus inhibitor targeting multiple allosteric sites of NS5B polymerase.
Khalid H; Landry KB; Ijaz B; Ashfaq UA; Ahmed M; Kanwal A; Froeyen M; Mirza MU
Infect Genet Evol; 2020 Oct; 84():104371. PubMed ID: 32485331
[TBL] [Abstract][Full Text] [Related]
14. Multiple e-pharmacophore modeling, 3D-QSAR, and high-throughput virtual screening of hepatitis C virus NS5B polymerase inhibitors.
Therese PJ; Manvar D; Kondepudi S; Battu MB; Sriram D; Basu A; Yogeeswari P; Kaushik-Basu N
J Chem Inf Model; 2014 Feb; 54(2):539-52. PubMed ID: 24460140
[TBL] [Abstract][Full Text] [Related]
15. Identification of anthranilic acid derivatives as a novel class of allosteric inhibitors of hepatitis C NS5B polymerase.
Nittoli T; Curran K; Insaf S; DiGrandi M; Orlowski M; Chopra R; Agarwal A; Howe AY; Prashad A; Floyd MB; Johnson B; Sutherland A; Wheless K; Feld B; O'Connell J; Mansour TS; Bloom J
J Med Chem; 2007 May; 50(9):2108-16. PubMed ID: 17402724
[TBL] [Abstract][Full Text] [Related]
16. Structure-based design of novel HCV NS5B thumb pocket 2 allosteric inhibitors with submicromolar gt1 replicon potency: discovery of a quinazolinone chemotype.
Beaulieu PL; Coulombe R; Duan J; Fazal G; Godbout C; Hucke O; Jakalian A; Joly MA; Lepage O; Llinàs-Brunet M; Naud J; Poirier M; Rioux N; Thavonekham B; Kukolj G; Stammers TA
Bioorg Med Chem Lett; 2013 Jul; 23(14):4132-40. PubMed ID: 23768906
[TBL] [Abstract][Full Text] [Related]
17. New pseudodimeric aurones as palm pocket inhibitors of Hepatitis C virus RNA-dependent RNA polymerase.
Meguellati A; Ahmed-Belkacem A; Nurisso A; Yi W; Brillet R; Berqouch N; Chavoutier L; Fortuné A; Pawlotsky JM; Boumendjel A; Peuchmaur M
Eur J Med Chem; 2016 Jun; 115():217-29. PubMed ID: 27017550
[TBL] [Abstract][Full Text] [Related]
18. Binding site characterization and resistance to a class of non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase.
Kukolj G; McGibbon GA; McKercher G; Marquis M; Lefèbvre S; Thauvette L; Gauthier J; Goulet S; Poupart MA; Beaulieu PL
J Biol Chem; 2005 Nov; 280(47):39260-7. PubMed ID: 16188890
[TBL] [Abstract][Full Text] [Related]
19. The versatile nature of the 6-aminoquinolone scaffold: identification of submicromolar hepatitis C virus NS5B inhibitors.
Manfroni G; Cannalire R; Barreca ML; Kaushik-Basu N; Leyssen P; Winquist J; Iraci N; Manvar D; Paeshuyse J; Guhamazumder R; Basu A; Sabatini S; Tabarrini O; Danielson UH; Neyts J; Cecchetti V
J Med Chem; 2014 Mar; 57(5):1952-63. PubMed ID: 24131104
[TBL] [Abstract][Full Text] [Related]
20. 2-(3-Thienyl)-5,6-dihydroxypyrimidine-4-carboxylic acids as inhibitors of HCV NS5B RdRp.
Pacini B; Avolio S; Ercolani C; Koch U; Migliaccio G; Narjes F; Pacini L; Tomei L; Harper S
Bioorg Med Chem Lett; 2009 Nov; 19(21):6245-9. PubMed ID: 19800789
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
