149 related articles for article (PubMed ID: 22212721)
1. Biological evaluation and docking studies of recently identified inhibitors of phosphoinositide-3-kinases.
Sabbah DA; Simms NA; Brattain MG; Vennerstrom JL; Zhong H
Bioorg Med Chem Lett; 2012 Jan; 22(2):876-80. PubMed ID: 22212721
[TBL] [Abstract][Full Text] [Related]
2. N-Phenyl-4-hydroxy-2-quinolone-3-carboxamides as selective inhibitors of mutant H1047R phosphoinositide-3-kinase (PI3Kα).
Sabbah DA; Simms NA; Wang W; Dong Y; Ezell EL; Brattain MG; Vennerstrom JL; Zhong HA
Bioorg Med Chem; 2012 Dec; 20(24):7175-83. PubMed ID: 23121722
[TBL] [Abstract][Full Text] [Related]
3. Synthesis, biological evaluation and structure-activity relationship of a novel class of PI3Kα H1047R mutant inhibitors.
Zhang N; Yu Z; Yang X; Zhou Y; Wang J; Zhang SL; Wang MW; He Y
Eur J Med Chem; 2018 Oct; 158():707-719. PubMed ID: 30245395
[TBL] [Abstract][Full Text] [Related]
4. Molecular modeling based approach, synthesis, and cytotoxic activity of novel benzoin derivatives targeting phosphoinostide 3-kinase (PI3Kα).
Sabbah DA; Saada M; Khalaf RA; Bardaweel S; Sweidan K; Al-Qirim T; Al-Zughier A; Halim HA; Sheikha GA
Bioorg Med Chem Lett; 2015 Aug; 25(16):3120-4. PubMed ID: 26099539
[TBL] [Abstract][Full Text] [Related]
5. Difuran-substituted quinoxalines as a novel class of PI3Kα H1047R mutant inhibitors: Synthesis, biological evaluation and structure-activity relationship.
Zhang N; Yu Z; Yang X; Zhou Y; Tang Q; Hu P; Wang J; Zhang SL; Wang MW; He Y
Eur J Med Chem; 2018 Sep; 157():37-49. PubMed ID: 30071408
[TBL] [Abstract][Full Text] [Related]
6. Docking Studies and Antiproliferative Activities of 6-(3-aryl-2-propenoyl)-2(3H)- benzoxazolone Derivatives as Novel Inhibitors of Phosphatidylinositol 3-Kinase (PI3Kα).
Bilginer S; Bardaweel SK; Sabbah DA; Gul HI
Anticancer Agents Med Chem; 2021; 21(6):716-724. PubMed ID: 32767959
[TBL] [Abstract][Full Text] [Related]
7. Docking studies on isoform-specific inhibition of phosphoinositide-3-kinases.
Sabbah DA; Vennerstrom JL; Zhong H
J Chem Inf Model; 2010 Oct; 50(10):1887-98. PubMed ID: 20866085
[TBL] [Abstract][Full Text] [Related]
8. Development of novel chromeno[4,3-c]pyrazol-4(2H)-one derivates bearing sulfonylpiperazine as antitumor inhibitors targeting PI3Kα.
Yin Y; Sha S; Wu X; Wang SF; Qiao F; Song ZC; Zhu HL
Eur J Med Chem; 2019 Nov; 182():111630. PubMed ID: 31446244
[TBL] [Abstract][Full Text] [Related]
9. Computer-aided design, synthesis, and biological evaluation of new indole-2-carboxamide derivatives as PI3Kα/EGFR inhibitors.
Sweidan K; Sabbah DA; Bardaweel S; Dush KA; Sheikha GA; Mubarak MS
Bioorg Med Chem Lett; 2016 Jun; 26(11):2685-90. PubMed ID: 27084677
[TBL] [Abstract][Full Text] [Related]
10. Novel 4-aminoquinazoline derivatives induce growth inhibition, cell cycle arrest and apoptosis via PI3Kα inhibition.
Fan YH; Ding HW; Liu DD; Song HR; Xu YN; Wang J
Bioorg Med Chem; 2018 May; 26(8):1675-1685. PubMed ID: 29475582
[TBL] [Abstract][Full Text] [Related]
11. The Rational Design of Selective Benzoxazepin Inhibitors of the α-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-Isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326).
Heffron TP; Heald RA; Ndubaku C; Wei B; Augistin M; Do S; Edgar K; Eigenbrot C; Friedman L; Gancia E; Jackson PS; Jones G; Kolesnikov A; Lee LB; Lesnick JD; Lewis C; McLean N; Mörtl M; Nonomiya J; Pang J; Price S; Prior WW; Salphati L; Sideris S; Staben ST; Steinbacher S; Tsui V; Wallin J; Sampath D; Olivero AG
J Med Chem; 2016 Feb; 59(3):985-1002. PubMed ID: 26741947
[TBL] [Abstract][Full Text] [Related]
12. Discovery of Chromeno[4,3-c]pyrazol-4(2H)-one Containing Carbonyl or Oxime Derivatives as Potential, Selective Inhibitors PI3Kα.
Lu L; Sha S; Wang K; Zhang YH; Liu YD; Ju GD; Wang B; Zhu HL
Chem Pharm Bull (Tokyo); 2016 Nov; 64(11):1576-1581. PubMed ID: 27581755
[TBL] [Abstract][Full Text] [Related]
13. Structure-Based Design: Synthesis, X-ray Crystallography, and Biological Evaluation of N-Substituted-4-Hydroxy-2-Quinolone-3-Carboxamides as Potential Cytotoxic Agents.
Sabbah DA; Hishmah B; Sweidan K; Bardaweel S; AlDamen M; Zhong HA; Abu Khalaf R; Hasan Ibrahim A; Al-Qirim T; Abu Sheikha G; Mubarak MS
Anticancer Agents Med Chem; 2018; 18(2):263-276. PubMed ID: 28901259
[TBL] [Abstract][Full Text] [Related]
14. Synthesis, anticancer and antimicrobial evaluation of new benzofuran based derivatives: PI3K inhibition, quorum sensing and molecular modeling study.
El-Khouly OA; Henen MA; El-Sayed MA; Shabaan MI; El-Messery SM
Bioorg Med Chem; 2021 Feb; 31():115976. PubMed ID: 33388654
[TBL] [Abstract][Full Text] [Related]
15. Design, synthesis, and biological evaluation of novel 3-substituted imidazo[1,2-a]pyridine and quinazolin-4(3H)-one derivatives as PI3Kα inhibitors.
Fan YH; Li W; Liu DD; Bai MX; Song HR; Xu YN; Lee S; Zhou ZP; Wang J; Ding HW
Eur J Med Chem; 2017 Oct; 139():95-106. PubMed ID: 28800461
[TBL] [Abstract][Full Text] [Related]
16. Ligand-Based Drug Design: Synthesis and Biological Evaluation of Substituted Benzoin Derivatives as Potential Antitumor Agents.
Sabbah DA; Ibrahim AH; Talib WH; Alqaisi KM; Sweidan K; Bardaweel SK; Sheikha GA; Zhong HA; Al-Shalabi E; Khalaf RA; Mubarak MS
Med Chem; 2019; 15(4):417-429. PubMed ID: 30207238
[TBL] [Abstract][Full Text] [Related]
17. Design, synthesis and biological evaluation of novel series of 2H-benzo[b][1,4]oxazin-3(4H)-one and 2H-benzo[b][1,4]oxazine scaffold derivatives as PI3Kα inhibitors.
Dong FD; Liu DD; Deng CL; Qin XC; Chen K; Wang J; Song HR; Ding HW
Bioorg Med Chem; 2018 Aug; 26(14):3982-3991. PubMed ID: 29937355
[TBL] [Abstract][Full Text] [Related]
18. Volatile Inhibitors of Phosphatidylinositol-3-Kinase (PI3K) Pathway: Anticancer Potential of Aroma Compounds of Plant Essential Oils.
Bordoloi M; Saikia S; Kolita B; Sarmah R; Roy S; Narzary B
Anticancer Agents Med Chem; 2018; 18(1):87-109. PubMed ID: 28356026
[TBL] [Abstract][Full Text] [Related]
19. Design, synthesis, and biological evaluation of pyrazolopyrimidine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (part I).
Zhang L; Fan J; Chong JH; Cesena A; Tam BY; Gilson C; Boykin C; Wang D; Aivazian D; Marcotte D; Xiao G; Le Brazidec JY; Piao J; Lundgren K; Hong K; Vu K; Nguyen K; Gan LS; Silvian L; Ling L; Teng M; Reff M; Takeda N; Timple N; Wang Q; Morena R; Khan S; Zhao S; Li T; Lee WC; Taveras AG; Chao J
Bioorg Med Chem Lett; 2011 Sep; 21(18):5633-7. PubMed ID: 21798738
[TBL] [Abstract][Full Text] [Related]
20. Benzoin Schiff Bases: Design, Synthesis, and Biological Evaluation as Potential Antitumor Agents.
Sabbah DA; Al-Tarawneh F; Talib WH; Sweidan K; Bardaweel SK; Al-Shalabi E; Zhong HA; Abu Sheikha G; Abu Khalaf R; Mubarak MS
Med Chem; 2018; 14(7):695-708. PubMed ID: 29651943
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]