248 related articles for article (PubMed ID: 22215675)
1. Wilms tumor gene on X chromosome (WTX) inhibits degradation of NRF2 protein through competitive binding to KEAP1 protein.
Camp ND; James RG; Dawson DW; Yan F; Davison JM; Houck SA; Tang X; Zheng N; Major MB; Moon RT
J Biol Chem; 2012 Feb; 287(9):6539-50. PubMed ID: 22215675
[TBL] [Abstract][Full Text] [Related]
2. Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling.
Major MB; Camp ND; Berndt JD; Yi X; Goldenberg SJ; Hubbert C; Biechele TL; Gingras AC; Zheng N; Maccoss MJ; Angers S; Moon RT
Science; 2007 May; 316(5827):1043-6. PubMed ID: 17510365
[TBL] [Abstract][Full Text] [Related]
3. SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner.
Rada P; Rojo AI; Chowdhry S; McMahon M; Hayes JD; Cuadrado A
Mol Cell Biol; 2011 Mar; 31(6):1121-33. PubMed ID: 21245377
[TBL] [Abstract][Full Text] [Related]
4. p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription.
Jain A; Lamark T; Sjøttem E; Larsen KB; Awuh JA; Øvervatn A; McMahon M; Hayes JD; Johansen T
J Biol Chem; 2010 Jul; 285(29):22576-91. PubMed ID: 20452972
[TBL] [Abstract][Full Text] [Related]
5. Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination.
Hast BE; Goldfarb D; Mulvaney KM; Hast MA; Siesser PF; Yan F; Hayes DN; Major MB
Cancer Res; 2013 Apr; 73(7):2199-210. PubMed ID: 23382044
[TBL] [Abstract][Full Text] [Related]
6. Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of β-TrCP and GSK-3.
Hayes JD; Chowdhry S; Dinkova-Kostova AT; Sutherland C
Biochem Soc Trans; 2015 Aug; 43(4):611-20. PubMed ID: 26551701
[TBL] [Abstract][Full Text] [Related]
7. A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62.
Lau A; Wang XJ; Zhao F; Villeneuve NF; Wu T; Jiang T; Sun Z; White E; Zhang DD
Mol Cell Biol; 2010 Jul; 30(13):3275-85. PubMed ID: 20421418
[TBL] [Abstract][Full Text] [Related]
8. Functional inactivation of the WTX gene is not a frequent event in Wilms' tumors.
Perotti D; Gamba B; Sardella M; Spreafico F; Terenziani M; Collini P; Pession A; Nantron M; Fossati-Bellani F; Radice P
Oncogene; 2008 Jul; 27(33):4625-32. PubMed ID: 18391980
[TBL] [Abstract][Full Text] [Related]
9. Regulation of the Nrf2-Keap1 antioxidant response by the ubiquitin proteasome system: an insight into cullin-ring ubiquitin ligases.
Villeneuve NF; Lau A; Zhang DD
Antioxid Redox Signal; 2010 Dec; 13(11):1699-712. PubMed ID: 20486766
[TBL] [Abstract][Full Text] [Related]
10. Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1.
Eggler AL; Small E; Hannink M; Mesecar AD
Biochem J; 2009 Jul; 422(1):171-80. PubMed ID: 19489739
[TBL] [Abstract][Full Text] [Related]
11. Fas-associated factor 1 is a scaffold protein that promotes β-transducin repeat-containing protein (β-TrCP)-mediated β-catenin ubiquitination and degradation.
Zhang L; Zhou F; Li Y; Drabsch Y; Zhang J; van Dam H; ten Dijke P
J Biol Chem; 2012 Aug; 287(36):30701-10. PubMed ID: 22730322
[TBL] [Abstract][Full Text] [Related]
12. Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.
Zhang DD; Lo SC; Cross JV; Templeton DJ; Hannink M
Mol Cell Biol; 2004 Dec; 24(24):10941-53. PubMed ID: 15572695
[TBL] [Abstract][Full Text] [Related]
13. Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity.
Chowdhry S; Zhang Y; McMahon M; Sutherland C; Cuadrado A; Hayes JD
Oncogene; 2013 Aug; 32(32):3765-81. PubMed ID: 22964642
[TBL] [Abstract][Full Text] [Related]
14. Berberine inhibits Wilms' tumor cell progression through upregulation of Wilms' tumor gene on the X chromosome.
Liu Y; Liu S
Mol Med Rep; 2013 Nov; 8(5):1537-41. PubMed ID: 24002362
[TBL] [Abstract][Full Text] [Related]
15. Stat3 inhibits WTX expression through up-regulation of microRNA-370 in Wilms tumor.
Cao X; Liu D; Yan X; Zhang Y; Yuan L; Zhang T; Fu M; Zhou Y; Wang J
FEBS Lett; 2013 Mar; 587(6):639-44. PubMed ID: 23333300
[TBL] [Abstract][Full Text] [Related]
16. Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2.
Sun Z; Zhang S; Chan JY; Zhang DD
Mol Cell Biol; 2007 Sep; 27(18):6334-49. PubMed ID: 17636022
[TBL] [Abstract][Full Text] [Related]
17. Antioxidant-induced INrf2 (Keap1) tyrosine 85 phosphorylation controls the nuclear export and degradation of the INrf2-Cul3-Rbx1 complex to allow normal Nrf2 activation and repression.
Kaspar JW; Niture SK; Jaiswal AK
J Cell Sci; 2012 Feb; 125(Pt 4):1027-38. PubMed ID: 22448038
[TBL] [Abstract][Full Text] [Related]
18. The Keap1-Nrf2 system as an in vivo sensor for electrophiles.
Uruno A; Motohashi H
Nitric Oxide; 2011 Aug; 25(2):153-60. PubMed ID: 21385624
[TBL] [Abstract][Full Text] [Related]
19. USP15 negatively regulates Nrf2 through deubiquitination of Keap1.
Villeneuve NF; Tian W; Wu T; Sun Z; Lau A; Chapman E; Fang D; Zhang DD
Mol Cell; 2013 Jul; 51(1):68-79. PubMed ID: 23727018
[TBL] [Abstract][Full Text] [Related]
20. [Prothyomosin alpha interaction with KEAP1 doesn't lead to prothymosin alpha ubiquination and degradation].
Mel'nikov SV; Evstaf'eva AG; Vartapetian AB
Mol Biol (Mosk); 2007; 41(5):868-75. PubMed ID: 18240569
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
