697 related articles for article (PubMed ID: 22217465)
1. In vitro metabolism of BIIB021, an inhibitor of heat shock protein 90, in liver microsomes and hepatocytes of rats, dogs, and humans and recombinant human cytochrome P450 isoforms.
Xu L; Woodward C; Khan S; Prakash C
Drug Metab Dispos; 2012 Apr; 40(4):680-93. PubMed ID: 22217465
[TBL] [Abstract][Full Text] [Related]
2. Metabolism and excretion of 6-chloro-9-(4-methoxy-3,5-dimethylpyridin-2-ylmethyl)-9H-purin-2-ylamine, an HSP90 inhibitor, in rats and dogs and assessment of its metabolic profile in plasma of humans.
Xu L; Woodward C; Dai J; Prakash C
Drug Metab Dispos; 2013 Dec; 41(12):2133-47. PubMed ID: 24046333
[TBL] [Abstract][Full Text] [Related]
3. Metabolism of the new anxiolytic agent, a pyrido[1,2-]benzimidazole (PBI) analog (RWJ-53050), in rat and human hepatic S9 fractions, and in dog; identification of cytochrome p450 isoforms mediated in the human microsomal metabolism.
Wu WN; McKown LA; Reitz AB
Eur J Drug Metab Pharmacokinet; 2006; 31(4):277-83. PubMed ID: 17315539
[TBL] [Abstract][Full Text] [Related]
4. Biotransformation of 6-methoxy-3-(3',4',5'-trimethoxy-benzoyl)-1H-indole (BPR0L075), a novel antimicrotubule agent, by mouse, rat, dog, and human liver microsomes.
Yao HT; Wu YS; Chang YW; Hsieh HP; Chen WC; Lan SJ; Chen CT; Chao YS; Chang L; Sun HY; Yeh TK
Drug Metab Dispos; 2007 Jul; 35(7):1042-9. PubMed ID: 17403915
[TBL] [Abstract][Full Text] [Related]
5. Characterization of metabolites of a NK1 receptor antagonist, CJ-11,972, in human liver microsomes and recombinant human CYP isoforms by liquid chromatography/tandem mass spectrometry.
Prakash C; Lin J; Colizza K; Miao Z
Rapid Commun Mass Spectrom; 2007; 21(17):2822-32. PubMed ID: 17661339
[TBL] [Abstract][Full Text] [Related]
6. Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes.
Jiang R; Yamaori S; Takeda S; Yamamoto I; Watanabe K
Life Sci; 2011 Aug; 89(5-6):165-70. PubMed ID: 21704641
[TBL] [Abstract][Full Text] [Related]
7. CYP2C8- and CYP3A-mediated C-demethylation of (3-{[(4-tert-butylbenzyl)-(pyridine-3-sulfonyl)-amino]-methyl}-phenoxy)-acetic acid (CP-533,536), an EP2 receptor-selective prostaglandin E2 agonist: characterization of metabolites by high-resolution liquid chromatography-tandem mass spectrometry and liquid chromatography/mass spectrometry-nuclear magnetic resonance.
Prakash C; Wang W; O'Connell T; Johnson KA
Drug Metab Dispos; 2008 Oct; 36(10):2093-103. PubMed ID: 18653741
[TBL] [Abstract][Full Text] [Related]
8. In vitro assessment of metabolic drug-drug interaction potential of apixaban through cytochrome P450 phenotyping, inhibition, and induction studies.
Wang L; Zhang D; Raghavan N; Yao M; Ma L; Frost CE; Maxwell BD; Chen SY; He K; Goosen TC; Humphreys WG; Grossman SJ
Drug Metab Dispos; 2010 Mar; 38(3):448-58. PubMed ID: 19940026
[TBL] [Abstract][Full Text] [Related]
9. In vitro liver metabolism of aclidinium bromide in preclinical animal species and humans: identification of the human enzymes involved in its oxidative metabolism.
Albertí JJ; Sentellas S; Salvà M
Biochem Pharmacol; 2011 Mar; 81(6):761-76. PubMed ID: 21184745
[TBL] [Abstract][Full Text] [Related]
10. Identification of human liver cytochrome P450 enzymes involved in biotransformation of vicriviroc, a CCR5 receptor antagonist.
Ghosal A; Ramanathan R; Yuan Y; Hapangama N; Chowdhury SK; Kishnani NS; Alton KB
Drug Metab Dispos; 2007 Dec; 35(12):2186-95. PubMed ID: 17827338
[TBL] [Abstract][Full Text] [Related]
11. In vitro metabolism of oxymetazoline: evidence for bioactivation to a reactive metabolite.
Mahajan MK; Uttamsingh V; Daniels JS; Gan LS; LeDuc BW; Williams DA
Drug Metab Dispos; 2011 Apr; 39(4):693-702. PubMed ID: 21177487
[TBL] [Abstract][Full Text] [Related]
12. BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90.
Lundgren K; Zhang H; Brekken J; Huser N; Powell RE; Timple N; Busch DJ; Neely L; Sensintaffar JL; Yang YC; McKenzie A; Friedman J; Scannevin R; Kamal A; Hong K; Kasibhatla SR; Boehm MF; Burrows FJ
Mol Cancer Ther; 2009 Apr; 8(4):921-9. PubMed ID: 19372565
[TBL] [Abstract][Full Text] [Related]
13. In vitro and in vivo metabolism of a selective δ-opioid receptor.
Guo J; Gu C; Zhou D; Elmore CS; Bui KH; Grimm SW
Drug Metab Dispos; 2011 Oct; 39(10):1883-94. PubMed ID: 21752944
[TBL] [Abstract][Full Text] [Related]
14. In vitro biotransformation of a novel antimalarial cysteine protease inhibitor in human liver microsomes.
Zhang Y; Guo X; Lin ET; Benet LZ
Pharmacology; 1999 Mar; 58(3):147-59. PubMed ID: 9925971
[TBL] [Abstract][Full Text] [Related]
15. In vitro metabolism of rivaroxaban, an oral, direct factor Xa inhibitor, in liver microsomes and hepatocytes of rats, dogs, and humans.
Lang D; Freudenberger C; Weinz C
Drug Metab Dispos; 2009 May; 37(5):1046-55. PubMed ID: 19196846
[TBL] [Abstract][Full Text] [Related]
16. Metabolite-P450 complex formation by methylenedioxyphenyl HIV protease inhibitors in rat and human liver microsomes.
Chiba M; Nishime JA; Chen IW; Vastag KJ; Sahly YS; Kim BM; Dorsey BD; Vacca JP; Lin JH
Biochem Pharmacol; 1998 Jul; 56(2):223-30. PubMed ID: 9698076
[TBL] [Abstract][Full Text] [Related]
17. In-vitro metabolism of glycyrrhetinic acid by human and rat liver microsomes and its interactions with six CYP substrates.
Zhao K; Ding M; Cao H; Cao ZX
J Pharm Pharmacol; 2012 Oct; 64(10):1445-51. PubMed ID: 22943175
[TBL] [Abstract][Full Text] [Related]
18. Biotransformation of the antiretroviral drug etravirine: metabolite identification, reaction phenotyping, and characterization of autoinduction of cytochrome P450-dependent metabolism.
Yanakakis LJ; Bumpus NN
Drug Metab Dispos; 2012 Apr; 40(4):803-14. PubMed ID: 22269145
[TBL] [Abstract][Full Text] [Related]
19. Confirmation that cytochrome P450 2C8 (CYP2C8) plays a minor role in (S)-(+)- and (R)-(-)-ibuprofen hydroxylation in vitro.
Chang SY; Li W; Traeger SC; Wang B; Cui D; Zhang H; Wen B; Rodrigues AD
Drug Metab Dispos; 2008 Dec; 36(12):2513-22. PubMed ID: 18787056
[TBL] [Abstract][Full Text] [Related]
20. Roles of CYP3A4 and CYP2C19 in methyl hydroxylated and N-oxidized metabolite formation from voriconazole, a new anti-fungal agent, in human liver microsomes.
Murayama N; Imai N; Nakane T; Shimizu M; Yamazaki H
Biochem Pharmacol; 2007 Jun; 73(12):2020-6. PubMed ID: 17433262
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]