BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

168 related articles for article (PubMed ID: 22223051)

  • 1. Fragment-based screening for inhibitors of PDE4A using enthalpy arrays and X-ray crystallography.
    Recht MI; Sridhar V; Badger J; Hernandez L; Chie-Leon B; Nienaber V; Torres FE
    J Biomol Screen; 2012 Apr; 17(4):469-80. PubMed ID: 22223051
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Identification and optimization of PDE10A inhibitors using fragment-based screening by nanocalorimetry and X-ray crystallography.
    Recht MI; Sridhar V; Badger J; Bounaud PY; Logan C; Chie-Leon B; Nienaber V; Torres FE
    J Biomol Screen; 2014 Apr; 19(4):497-507. PubMed ID: 24375910
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Fragment-Based Screening for Enzyme Inhibitors Using Calorimetry.
    Recht MI; Nienaber V; Torres FE
    Methods Enzymol; 2016; 567():47-69. PubMed ID: 26794350
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Discovery of novel
    Sebastián-Pérez V; Schroeder S; Munday JC; van der Meer T; Zaldívar-Díez J; Siderius M; de Koning HP; Brown D; Martínez A; Campillo NE; Leurs R; Gil C
    Future Med Chem; 2019 Jul; 11(14):1703-1720. PubMed ID: 31370708
    [No Abstract]   [Full Text] [Related]  

  • 5. Docking Studies of Curcumin and Analogues with Various Phosphodiesterase 4 Subtypes.
    Yi YX; Gaurav A; Akowuah GA
    Curr Drug Discov Technol; 2020; 17(2):248-260. PubMed ID: 30332967
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Discovery of novel inhibitors of phosphodiesterase 4 with 1-phenyl-3,4-dihydroisoquinoline scaffold: Structure-based drug design and fragment identification.
    Liao Y; Jia X; Tang Y; Li S; Zang Y; Wang L; Cui ZN; Song G
    Bioorg Med Chem Lett; 2019 Nov; 29(22):126720. PubMed ID: 31610942
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Selaginpulvilins A-D, new phosphodiesterase-4 inhibitors with an unprecedented skeleton from Selaginella pulvinata.
    Liu X; Luo HB; Huang YY; Bao JM; Tang GH; Chen YY; Wang J; Yin S
    Org Lett; 2014 Jan; 16(1):282-5. PubMed ID: 24328835
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Discovery of potent, selective, bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model, part I: transformation of selective pyrazolodiazepinone phosphodiesterase 4 (PDE4) inhibitors into selective PDE2 inhibitors.
    Plummer MS; Cornicelli J; Roark H; Skalitzky DJ; Stankovic CJ; Bove S; Pandit J; Goodman A; Hicks J; Shahripour A; Beidler D; Lu XK; Sanchez B; Whitehead C; Sarver R; Braden T; Gowan R; Shen XQ; Welch K; Ogden A; Sadagopan N; Baum H; Miller H; Banotai C; Spessard C; Lightle S
    Bioorg Med Chem Lett; 2013 Jun; 23(11):3438-42. PubMed ID: 23582272
    [TBL] [Abstract][Full Text] [Related]  

  • 9. A yeast-based chemical screen identifies a PDE inhibitor that elevates steroidogenesis in mouse Leydig cells via PDE8 and PDE4 inhibition.
    Demirbas D; Wyman AR; Shimizu-Albergine M; Cakici O; Beavo JA; Hoffman CS
    PLoS One; 2013; 8(8):e71279. PubMed ID: 23967182
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors.
    Drinkwater N; Vu H; Lovell KM; Criscione KR; Collins BM; Prisinzano TE; Poulsen SA; McLeish MJ; Grunewald GL; Martin JL
    Biochem J; 2010 Oct; 431(1):51-61. PubMed ID: 20642456
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Pd-mediated functionalization of polysubstituted pyrroles: their evaluation as potential inhibitors of PDE4.
    Bhaskar Kumar T; Sumanth Ch; Vaishaly S; Srinivasa Rao M; Chandra Sekhar KB; Meda CL; Kandale A; Rambabu D; Rama Krishna G; Malla Reddy C; Shiva Kumar K; Parsa KV; Pal M
    Bioorg Med Chem Lett; 2012 Sep; 22(17):5639-47. PubMed ID: 22871579
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Design, synthesis, and biological evaluation of tetrahydroisoquinolines derivatives as novel, selective PDE4 inhibitors for antipsoriasis treatment.
    Zhang R; Li H; Zhang X; Li J; Su H; Lu Q; Dong G; Dou H; Fan C; Gu Z; Mu Q; Tang W; Xu Y; Liu H
    Eur J Med Chem; 2021 Feb; 211():113004. PubMed ID: 33218684
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Predicting the success of fragment screening by X-ray crystallography.
    Davies DR; Begley DW; Hartley RC; Staker BL; Stewart LJ
    Methods Enzymol; 2011; 493():91-114. PubMed ID: 21371588
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Memory enhancing effects of BPN14770, an allosteric inhibitor of phosphodiesterase-4D, in wild-type and humanized mice.
    Zhang C; Xu Y; Chowdhary A; Fox D; Gurney ME; Zhang HT; Auerbach BD; Salvi RJ; Yang M; Li G; O'Donnell JM
    Neuropsychopharmacology; 2018 Oct; 43(11):2299-2309. PubMed ID: 30131563
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Exploring the Role of Water Molecules in the Ligand Binding Domain of PDE4B and PDE4D: Virtual Screening Based Molecular Docking of Some Active Scaffolds.
    Singh P; Mishra M; Agarwal S; Sau S; Iyer AK; Kashaw SK
    Curr Comput Aided Drug Des; 2019; 15(4):334-366. PubMed ID: 30394213
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Thiophene inhibitors of PDE4: crystal structures show a second binding mode at the catalytic domain of PDE4D2.
    Nankervis JL; Feil SC; Hancock NC; Zheng Z; Ng HL; Morton CJ; Holien JK; Ho PW; Frazzetto MM; Jennings IG; Manallack DT; Martin TJ; Thompson PE; Parker MW
    Bioorg Med Chem Lett; 2011 Dec; 21(23):7089-93. PubMed ID: 22030030
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Phosphodiesterase-4 promotes proliferation and angiogenesis of lung cancer by crosstalk with HIF.
    Pullamsetti SS; Banat GA; Schmall A; Szibor M; Pomagruk D; Hänze J; Kolosionek E; Wilhelm J; Braun T; Grimminger F; Seeger W; Schermuly RT; Savai R
    Oncogene; 2013 Feb; 32(9):1121-34. PubMed ID: 22525277
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Discovery and Optimization of Thiazolidinyl and Pyrrolidinyl Derivatives as Inhaled PDE4 Inhibitors for Respiratory Diseases.
    Carzaniga L; Amari G; Rizzi A; Capaldi C; De Fanti R; Ghidini E; Villetti G; Carnini C; Moretto N; Facchinetti F; Caruso P; Marchini G; Battipaglia L; Patacchini R; Cenacchi V; Volta R; Amadei F; Pappani A; Capacchi S; Bagnacani V; Delcanale M; Puccini P; Catinella S; Civelli M; Armani E
    J Med Chem; 2017 Dec; 60(24):10026-10046. PubMed ID: 29200281
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Benzoquinones and terphenyl compounds as phosphodiesterase-4B inhibitors from a fungus of the order Chaetothyriales (MSX 47445).
    El-Elimat T; Figueroa M; Raja HA; Graf TN; Adcock AF; Kroll DJ; Day CS; Wani MC; Pearce CJ; Oberlies NH
    J Nat Prod; 2013 Mar; 76(3):382-7. PubMed ID: 23301853
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Advances in the Development of Phosphodiesterase-4 Inhibitors.
    Peng T; Qi B; He J; Ke H; Shi J
    J Med Chem; 2020 Oct; 63(19):10594-10617. PubMed ID: 32255344
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.