183 related articles for article (PubMed ID: 22245230)
1. Multi-receptor drug design: Haloperidol as a scaffold for the design and synthesis of atypical antipsychotic agents.
Peprah K; Zhu XY; Eyunni SV; Setola V; Roth BL; Ablordeppey SY
Bioorg Med Chem; 2012 Feb; 20(3):1291-7. PubMed ID: 22245230
[TBL] [Abstract][Full Text] [Related]
2. Identification of a butyrophenone analog as a potential atypical antipsychotic agent: 4-[4-(4-chlorophenyl)-1,4-diazepan-1-yl]-1-(4-fluorophenyl)butan-1-one.
Ablordeppey SY; Altundas R; Bricker B; Zhu XY; Kumar EV; Jackson T; Khan A; Roth BL
Bioorg Med Chem; 2008 Aug; 16(15):7291-301. PubMed ID: 18595716
[TBL] [Abstract][Full Text] [Related]
3. Conformationally constrained butyrophenones with affinity for dopamine (D(1), D(2), D(4)) and serotonin (5-HT(2A), 5-HT(2B), 5-HT(2C)) receptors: synthesis of aminomethylbenzo[b]furanones and their evaluation as antipsychotics.
Raviña E; Casariego I; Masaguer CF; Fontenla JA; Montenegro GY; Rivas ME; Loza MI; Enguix MJ; Villazon M; Cadavid MI; Demontis GC
J Med Chem; 2000 Nov; 43(24):4678-93. PubMed ID: 11101359
[TBL] [Abstract][Full Text] [Related]
4. Synthesis and atypical antipsychotic profile of some 2-(2-piperidinoethyl)benzocycloalkanones as analogues of butyrophenone.
Fontenla JA; Osuna J; Rosa E; Castro ME; G-Ferreiro T; Loza-García I; Calleja JM; Sanz F; Rodríguez J; Raviña E
J Med Chem; 1994 Aug; 37(16):2564-73. PubMed ID: 7914540
[TBL] [Abstract][Full Text] [Related]
5. Structure-activity relationship studies of SYA 013, a homopiperazine analog of haloperidol.
Peprah K; Zhu XY; Eyunni SV; Etukala JR; Setola V; Roth BL; Ablordeppey SY
Bioorg Med Chem; 2012 Mar; 20(5):1671-8. PubMed ID: 22336245
[TBL] [Abstract][Full Text] [Related]
6. Synthesis and evaluation of ligands for D2-like receptors: the role of common pharmacophoric groups.
Sikazwe DM; Nkansah NT; Altundas R; Zhu XY; Roth BL; Setola V; Ablordeppey SY
Bioorg Med Chem; 2009 Feb; 17(4):1716-23. PubMed ID: 19155177
[TBL] [Abstract][Full Text] [Related]
7. Conformationally constrained butyrophenones with mixed dopaminergic (D(2)) and serotoninergic (5-HT(2A), 5-HT(2C)) affinities: synthesis, pharmacology, 3D-QSAR, and molecular modeling of (aminoalkyl)benzo- and -thienocycloalkanones as putative atypical antipsychotics.
Raviña E; Negreira J; Cid J; Masaguer CF; Rosa E; Rivas ME; Fontenla JA; Loza MI; Tristán H; Cadavid MI; Sanz F; Lozoya E; Carotti A; Carrieri A
J Med Chem; 1999 Jul; 42(15):2774-97. PubMed ID: 10425088
[TBL] [Abstract][Full Text] [Related]
8. QF2004B, a potential antipsychotic butyrophenone derivative with similar pharmacological properties to clozapine.
Brea J; Castro M; Loza MI; Masaguer CF; Raviña E; Dezi C; Pastor M; Sanz F; Cabrero-Castel A; Galán-Rodríguez B; Fernández-Espejo E; Maldonado R; Robledo P
Neuropharmacology; 2006 Aug; 51(2):251-62. PubMed ID: 16697427
[TBL] [Abstract][Full Text] [Related]
9. Current strategies for the development of novel antipsychotic drugs.
Bolós J
Mini Rev Med Chem; 2003 May; 3(3):239-51. PubMed ID: 12570839
[TBL] [Abstract][Full Text] [Related]
10. Behavioral pharmacologic studies in the monkey with DD-3480.
Shibuya T; Nishimori T; Matsuda H; Chen PC
Int J Clin Pharmacol Ther Toxicol; 1982 Jun; 20(6):251-4. PubMed ID: 6125481
[TBL] [Abstract][Full Text] [Related]
11. Antipsychotic drug effects on dopamine and serotonin receptors: in vitro binding and in vivo turnover studies.
Bacopoulos NG
J Pharmacol Exp Ther; 1981 Dec; 219(3):708-14. PubMed ID: 6170752
[TBL] [Abstract][Full Text] [Related]
12. Amisulpride the 'atypical' atypical antipsychotic--comparison to haloperidol, risperidone and clozapine.
Natesan S; Reckless GE; Barlow KB; Nobrega JN; Kapur S
Schizophr Res; 2008 Oct; 105(1-3):224-35. PubMed ID: 18710798
[TBL] [Abstract][Full Text] [Related]
13. Butyrophenone analogues in the carbazole series: synthesis and determination of affinities at D2 and 5-HT2A receptors.
Masaguer CF; Formoso E; Raviña E; Tristán H; Loza MI; Rivas E; Fontenla JA
Bioorg Med Chem Lett; 1998 Dec; 8(24):3571-6. PubMed ID: 9934473
[TBL] [Abstract][Full Text] [Related]
14. In vivo occupancy of dopamine receptors by antipsychotic drugs.
Meltzer HY; Stockmeier CA
Arch Gen Psychiatry; 1992 Jul; 49(7):588-9. PubMed ID: 1352678
[No Abstract] [Full Text] [Related]
15. Molecular combination of the dopamine and serotonin scaffolds yield in novel antipsychotic drug candidates - characterization by in vivo experiments.
Schulze M; Siol O; Robaa D; Mueller FK; Enzensperger C; Fleck C; Lehmann J
Arzneimittelforschung; 2012 May; 62(5):252-60. PubMed ID: 22488415
[TBL] [Abstract][Full Text] [Related]
16. Atypical antipsychotics: mechanism of action.
Seeman P
Can J Psychiatry; 2002 Feb; 47(1):27-38. PubMed ID: 11873706
[TBL] [Abstract][Full Text] [Related]
17. Discriminative stimulus properties of 1.25 and 5.0 mg/kg doses of clozapine in rats: examination of the role of dopamine, serotonin, and muscarinic receptor mechanisms.
Prus AJ; Baker LE; Meltzer HY
Pharmacol Biochem Behav; 2004 Feb; 77(2):199-208. PubMed ID: 14751446
[TBL] [Abstract][Full Text] [Related]
18. Effect of timiperone on 3H-spiroperidol binding to rat striatal dopamine receptors.
Tachizawa H; Sudo K; Sano M
Eur J Pharmacol; 1979 Nov; 59(3-4):245-51. PubMed ID: 43256
[TBL] [Abstract][Full Text] [Related]
19. In vivo receptor occupancy of NRA0045, a putative atypical antipsychotic, in rats.
Chaki S; Funakoshi T; Yoshikawa R; Okuyama S; Kumagai T; Nakazato A; Nagamine M; Tomisawa K
Neuropharmacology; 1999 Aug; 38(8):1185-94. PubMed ID: 10462131
[TBL] [Abstract][Full Text] [Related]
20. Evaluation of the effects of the enantiomers of reduced haloperidol, azaperol, and related 4-amino-1-arylbutanols on dopamine and sigma receptors.
Jaen JC; Caprathe BW; Pugsley TA; Wise LD; Akunne H
J Med Chem; 1993 Nov; 36(24):3929-36. PubMed ID: 7902870
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
