171 related articles for article (PubMed ID: 22245425)
1. Molecular interaction of the first 3 enzymes of the de novo pyrimidine biosynthetic pathway of Trypanosoma cruzi.
Nara T; Hashimoto M; Hirawake H; Liao CW; Fukai Y; Suzuki S; Tsubouchi A; Morales J; Takamiya S; Fujimura T; Taka H; Mineki R; Fan CK; Inaoka DK; Inoue M; Tanaka A; Harada S; Kita K; Aoki T
Biochem Biophys Res Commun; 2012 Feb; 418(1):140-3. PubMed ID: 22245425
[TBL] [Abstract][Full Text] [Related]
2. Critical importance of the de novo pyrimidine biosynthesis pathway for Trypanosoma cruzi growth in the mammalian host cell cytoplasm.
Hashimoto M; Morales J; Fukai Y; Suzuki S; Takamiya S; Tsubouchi A; Inoue S; Inoue M; Kita K; Harada S; Tanaka A; Aoki T; Nara T
Biochem Biophys Res Commun; 2012 Jan; 417(3):1002-6. PubMed ID: 22209850
[TBL] [Abstract][Full Text] [Related]
3. Structural Insight into the Core of CAD, the Multifunctional Protein Leading De Novo Pyrimidine Biosynthesis.
Moreno-Morcillo M; Grande-García A; Ruiz-Ramos A; Del Caño-Ochoa F; Boskovic J; Ramón-Maiques S
Structure; 2017 Jun; 25(6):912-923.e5. PubMed ID: 28552578
[TBL] [Abstract][Full Text] [Related]
4. Immunochemical analysis of the domain structure of CAD, the multifunctional protein that initiates pyrimidine biosynthesis in mammalian cells.
Grayson DR; Lee L; Evans DR
J Biol Chem; 1985 Dec; 260(29):15840-9. PubMed ID: 2866187
[TBL] [Abstract][Full Text] [Related]
5. CAD, A Multienzymatic Protein at the Head of de Novo Pyrimidine Biosynthesis.
Del Caño-Ochoa F; Moreno-Morcillo M; Ramón-Maiques S
Subcell Biochem; 2019; 93():505-538. PubMed ID: 31939163
[TBL] [Abstract][Full Text] [Related]
6. The evolutionary history of the first three enzymes in pyrimidine biosynthesis.
Davidson JN; Chen KC; Jamison RS; Musmanno LA; Kern CB
Bioessays; 1993 Mar; 15(3):157-64. PubMed ID: 8098212
[TBL] [Abstract][Full Text] [Related]
7. Pyrimidine Biosynthetic Enzyme CAD: Its Function, Regulation, and Diagnostic Potential.
Li G; Li D; Wang T; He S
Int J Mol Sci; 2021 Sep; 22(19):. PubMed ID: 34638594
[TBL] [Abstract][Full Text] [Related]
8. Molecular biology and biochemistry of malarial parasite pyrimidine biosynthetic pathway.
Krungkrai J; Prapunwatana P; Wichitkul C; Reungprapavut S; Krungkrai SR; Horii T
Southeast Asian J Trop Med Public Health; 2003; 34 Suppl 2():32-43. PubMed ID: 19230569
[TBL] [Abstract][Full Text] [Related]
9. Control of pyrimidine biosynthesis in the Ascaris ovary: regulatory properties of glutamine-dependent carbamoyl-phosphate synthetase and copurification of the enzyme with aspartate carbamoyltransferase and dihydroorotase.
Aoki T; Oya H; Mori M; Tatibana M
Mol Biochem Parasitol; 1980 Mar; 1(1):55-68. PubMed ID: 6108508
[TBL] [Abstract][Full Text] [Related]
10. Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis.
Robitaille AM; Christen S; Shimobayashi M; Cornu M; Fava LL; Moes S; Prescianotto-Baschong C; Sauer U; Jenoe P; Hall MN
Science; 2013 Mar; 339(6125):1320-3. PubMed ID: 23429704
[TBL] [Abstract][Full Text] [Related]
11. Glutamine-dependent carbamoyl-phosphate synthetase and control of pyrimidine biosynthesis in the parasitic helminth Schistosoma mansoni.
Aoki T; Oya H
Comp Biochem Physiol B; 1979; 63(4):511-5. PubMed ID: 45544
[TBL] [Abstract][Full Text] [Related]
12. Enzymes of pyrimidine biosynthesis in Trypanosoma cruzi.
Hammond DJ; Gutteridge WE
FEBS Lett; 1980 Sep; 118(2):259-62. PubMed ID: 6998735
[No Abstract] [Full Text] [Related]
13. Novel organization and sequences of five genes encoding all six enzymes for de novo pyrimidine biosynthesis in Trypanosoma cruzi.
Gao G; Nara T; Nakajima-Shimada J; Aoki T
J Mol Biol; 1999 Jan; 285(1):149-61. PubMed ID: 9878395
[TBL] [Abstract][Full Text] [Related]
14. Rheb protein binds CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamoylase, and dihydroorotase) protein in a GTP- and effector domain-dependent manner and influences its cellular localization and carbamoyl-phosphate synthetase (CPSase) activity.
Sato T; Akasu H; Shimono W; Matsu C; Fujiwara Y; Shibagaki Y; Heard JJ; Tamanoi F; Hattori S
J Biol Chem; 2015 Jan; 290(2):1096-105. PubMed ID: 25422319
[TBL] [Abstract][Full Text] [Related]
15. Dihydroorotase from the hyperthermophile Aquifex aeolicus is activated by stoichiometric association with aspartate transcarbamoylase and forms a one-pot reactor for pyrimidine biosynthesis.
Zhang P; Martin PD; Purcarea C; Vaishnav A; Brunzelle JS; Fernando R; Guy-Evans HI; Evans DR; Edwards BF
Biochemistry; 2009 Feb; 48(4):766-78. PubMed ID: 19128030
[TBL] [Abstract][Full Text] [Related]
16. Molecular cloning of a human cDNA encoding a trifunctional enzyme of carbamoyl-phosphate synthetase-aspartate transcarbamoylase-dihydroorotase in de Novo pyrimidine synthesis.
Iwahana H; Fujimura M; Ii S; Kondo M; Moritani M; Takahashi Y; Yamaoka T; Yoshimoto K; Itakura M
Biochem Biophys Res Commun; 1996 Feb; 219(1):249-55. PubMed ID: 8619816
[TBL] [Abstract][Full Text] [Related]
17. Allosteric regulation and substrate channeling in multifunctional pyrimidine biosynthetic complexes: analysis of isolated domains and yeast-mammalian chimeric proteins.
Serre V; Guy H; Liu X; Penverne B; Hervé G; Evans D
J Mol Biol; 1998 Aug; 281(2):363-77. PubMed ID: 9698553
[TBL] [Abstract][Full Text] [Related]
18. The multienzymatic protein CAD leading the de novo biosynthesis of pyrimidines localizes exclusively in the cytoplasm and does not translocate to the nucleus.
Del Caño-Ochoa F; Ramón-Maiques S
Nucleosides Nucleotides Nucleic Acids; 2020; 39(10-12):1320-1334. PubMed ID: 31997698
[TBL] [Abstract][Full Text] [Related]
19. The human Rad9 checkpoint protein stimulates the carbamoyl phosphate synthetase activity of the multifunctional protein CAD.
Lindsey-Boltz LA; Wauson EM; Graves LM; Sancar A
Nucleic Acids Res; 2004; 32(15):4524-30. PubMed ID: 15326225
[TBL] [Abstract][Full Text] [Related]
20. Phosphorylation, allosteric effectors and inter-domain contacts in CAD; their role in regulation of early steps of pyrimidine biosynthesis.
Carrey EA
Biochem Soc Trans; 1993 Feb; 21(1):191-5. PubMed ID: 8095470
[No Abstract] [Full Text] [Related]
[Next] [New Search]