BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

108 related articles for article (PubMed ID: 22245630)

  • 1. Effects of Src kinase inhibition by saracatinib (AZD0530) on bone turnover in advanced malignancy in a Phase I study.
    Hannon RA; Finkelman RD; Clack G; Iacona RB; Rimmer M; Gossiel F; Baselga J; Eastell R
    Bone; 2012 Apr; 50(4):885-92. PubMed ID: 22245630
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Effects of the Src kinase inhibitor saracatinib (AZD0530) on bone turnover in healthy men: a randomized, double-blind, placebo-controlled, multiple-ascending-dose phase I trial.
    Hannon RA; Clack G; Rimmer M; Swaisland A; Lockton JA; Finkelman RD; Eastell R
    J Bone Miner Res; 2010 Mar; 25(3):463-71. PubMed ID: 19775203
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Phase I safety, pharmacokinetics, and inhibition of SRC activity study of saracatinib in patients with solid tumors.
    Baselga J; Cervantes A; Martinelli E; Chirivella I; Hoekman K; Hurwitz HI; Jodrell DI; Hamberg P; Casado E; Elvin P; Swaisland A; Iacona R; Tabernero J
    Clin Cancer Res; 2010 Oct; 16(19):4876-83. PubMed ID: 20805299
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Effect of the specific Src family kinase inhibitor saracatinib on osteolytic lesions using the PC-3 bone model.
    Yang JC; Bai L; Yap S; Gao AC; Kung HJ; Evans CP
    Mol Cancer Ther; 2010 Jun; 9(6):1629-37. PubMed ID: 20484016
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Effects of the Src inhibitor saracatinib (AZD0530) on renal function in healthy subjects.
    Dalton RN; Chetty R; Stuart M; Iacona RB; Swaisland A
    Anticancer Res; 2010 Jul; 30(7):2935-42. PubMed ID: 20683035
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Effects of Src-kinase inhibition in cancer-induced bone pain.
    De Felice M; Lambert D; Holen I; Escott KJ; Andrew D
    Mol Pain; 2016; 12():. PubMed ID: 27094550
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Phase II study of saracatinib (AZD0530) in patients with previously treated metastatic colorectal cancer.
    Reddy SM; Kopetz S; Morris J; Parikh N; Qiao W; Overman MJ; Fogelman D; Shureiqi I; Jacobs C; Malik Z; Jimenez CA; Wolff RA; Abbruzzese JL; Gallick G; Eng C
    Invest New Drugs; 2015 Aug; 33(4):977-84. PubMed ID: 26062928
    [TBL] [Abstract][Full Text] [Related]  

  • 8. SRC kinase inhibition with saracatinib limits the development of osteolytic bone disease in multiple myeloma.
    Heusschen R; Muller J; Binsfeld M; Marty C; Plougonven E; Dubois S; Mahli N; Moermans K; Carmeliet G; Léonard A; Baron F; Beguin Y; Menu E; Cohen-Solal M; Caers J
    Oncotarget; 2016 May; 7(21):30712-29. PubMed ID: 27095574
    [TBL] [Abstract][Full Text] [Related]  

  • 9. First report of the safety, tolerability, and pharmacokinetics of the Src kinase inhibitor saracatinib (AZD0530) in Japanese patients with advanced solid tumours.
    Fujisaka Y; Onozawa Y; Kurata T; Yasui H; Goto I; Yamazaki K; Machida N; Watanabe J; Shimada H; Shi X; Boku N
    Invest New Drugs; 2013 Feb; 31(1):108-14. PubMed ID: 22415795
    [TBL] [Abstract][Full Text] [Related]  

  • 10. A phase II study of saracatinib (AZD0530), a Src inhibitor, administered orally daily to patients with advanced thymic malignancies.
    Gubens MA; Burns M; Perkins SM; Pedro-Salcedo MS; Althouse SK; Loehrer PJ; Wakelee HA
    Lung Cancer; 2015 Jul; 89(1):57-60. PubMed ID: 26009269
    [TBL] [Abstract][Full Text] [Related]  

  • 11. A phase II trial of the Src-kinase inhibitor AZD0530 in patients with advanced castration-resistant prostate cancer: a California Cancer Consortium study.
    Lara PN; Longmate J; Evans CP; Quinn DI; Twardowski P; Chatta G; Posadas E; Stadler W; Gandara DR
    Anticancer Drugs; 2009 Mar; 20(3):179-84. PubMed ID: 19396016
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Phase II study of the Src kinase inhibitor saracatinib (AZD0530) in metastatic melanoma.
    Gangadhar TC; Clark JI; Karrison T; Gajewski TF
    Invest New Drugs; 2013 Jun; 31(3):769-73. PubMed ID: 23151808
    [TBL] [Abstract][Full Text] [Related]  

  • 13. A phase II trial of the Src kinase inhibitor saracatinib (AZD0530) in patients with metastatic or locally advanced gastric or gastro esophageal junction (GEJ) adenocarcinoma: a trial of the PMH phase II consortium.
    Mackay HJ; Au HJ; McWhirter E; Alcindor T; Jarvi A; MacAlpine K; Wang L; Wright JJ; Oza AM
    Invest New Drugs; 2012 Jun; 30(3):1158-63. PubMed ID: 21400081
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Impact of the Src inhibitor saracatinib on the metastatic phenotype of a fibrosarcoma (KHT) tumor model.
    Dong M; Rice L; Lepler S; Pampo C; Siemann DW
    Anticancer Res; 2010 Nov; 30(11):4405-13. PubMed ID: 21115886
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A phase II trial of the Src-kinase inhibitor saracatinib after four cycles of chemotherapy for patients with extensive stage small cell lung cancer: NCCTG trial N-0621.
    Molina JR; Foster NR; Reungwetwattana T; Nelson GD; Grainger AV; Steen PD; Stella PJ; Marks R; Wright J; Adjei AA
    Lung Cancer; 2014 Aug; 85(2):245-50. PubMed ID: 24957683
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Src as a therapeutic target in men with prostate cancer and bone metastases.
    Saad F
    BJU Int; 2009 Feb; 103(4):434-40. PubMed ID: 19154462
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Phase II trial of saracatinib (AZD0530), an oral SRC-inhibitor for the treatment of patients with hormone receptor-negative metastatic breast cancer.
    Gucalp A; Sparano JA; Caravelli J; Santamauro J; Patil S; Abbruzzi A; Pellegrino C; Bromberg J; Dang C; Theodoulou M; Massague J; Norton L; Hudis C; Traina TA
    Clin Breast Cancer; 2011 Oct; 11(5):306-11. PubMed ID: 21729667
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Improved response by co-targeting EGFR/EGFRvIII and Src family kinases in human cancer cells.
    Andersen P; Villingshøj M; Poulsen HS; Stockhausen MT
    Cancer Invest; 2009 Feb; 27(2):178-83. PubMed ID: 19235590
    [TBL] [Abstract][Full Text] [Related]  

  • 19. SRC kinase inhibition: targeting bone metastases and tumor growth in prostate and breast cancer.
    Saad F; Lipton A
    Cancer Treat Rev; 2010 Apr; 36(2):177-84. PubMed ID: 20015594
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The Src inhibitor AZD0530 reversibly inhibits the formation and activity of human osteoclasts.
    de Vries TJ; Mullender MG; van Duin MA; Semeins CM; James N; Green TP; Everts V; Klein-Nulend J
    Mol Cancer Res; 2009 Apr; 7(4):476-88. PubMed ID: 19372577
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.