BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

120 related articles for article (PubMed ID: 22263962)

  • 1. Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic acid demethylase.
    Woon EC; Demetriades M; Bagg EA; Aik W; Krylova SM; Ma JH; Chan M; Walport LJ; Wegman DW; Dack KN; McDonough MA; Krylov SN; Schofield CJ
    J Med Chem; 2012 Mar; 55(5):2173-84. PubMed ID: 22263962
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Changes in protein dynamics of the DNA repair dioxygenase AlkB upon binding of Fe(2+) and 2-oxoglutarate.
    Bleijlevens B; Shivarattan T; van den Boom KS; de Haan A; van der Zwan G; Simpson PJ; Matthews SJ
    Biochemistry; 2012 Apr; 51(16):3334-41. PubMed ID: 22443471
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Mechanistic studies on the application of DNA aptamers as inhibitors of 2-oxoglutarate-dependent oxygenases.
    Krylova SM; Koshkin V; Bagg E; Schofield CJ; Krylov SN
    J Med Chem; 2012 Apr; 55(7):3546-52. PubMed ID: 22471443
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Crystal structures of catalytic complexes of the oxidative DNA/RNA repair enzyme AlkB.
    Yu B; Edstrom WC; Benach J; Hamuro Y; Weber PC; Gibney BR; Hunt JF
    Nature; 2006 Feb; 439(7078):879-84. PubMed ID: 16482161
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Large-scale examination of functional and sequence diversity of 2-oxoglutarate/Fe(II)-dependent oxygenases in Metazoa.
    Jia B; Tang K; Chun BH; Jeon CO
    Biochim Biophys Acta Gen Subj; 2017 Nov; 1861(11 Pt A):2922-2933. PubMed ID: 28847508
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Dynamic states of the DNA repair enzyme AlkB regulate product release.
    Bleijlevens B; Shivarattan T; Flashman E; Yang Y; Simpson PJ; Koivisto P; Sedgwick B; Schofield CJ; Matthews SJ
    EMBO Rep; 2008 Sep; 9(9):872-7. PubMed ID: 18617893
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches.
    Rose NR; Woon EC; Kingham GL; King ON; Mecinović J; Clifton IJ; Ng SS; Talib-Hardy J; Oppermann U; McDonough MA; Schofield CJ
    J Med Chem; 2010 Feb; 53(4):1810-8. PubMed ID: 20088513
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Inhibition of 2-oxoglutarate dependent oxygenases.
    Rose NR; McDonough MA; King ON; Kawamura A; Schofield CJ
    Chem Soc Rev; 2011 Aug; 40(8):4364-97. PubMed ID: 21390379
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structure of human phytanoyl-CoA 2-hydroxylase identifies molecular mechanisms of Refsum disease.
    McDonough MA; Kavanagh KL; Butler D; Searls T; Oppermann U; Schofield CJ
    J Biol Chem; 2005 Dec; 280(49):41101-10. PubMed ID: 16186124
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases.
    Rose NR; Ng SS; Mecinović J; Liénard BM; Bello SH; Sun Z; McDonough MA; Oppermann U; Schofield CJ
    J Med Chem; 2008 Nov; 51(22):7053-6. PubMed ID: 18942826
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Structure and functional analysis of YcfD, a novel 2-oxoglutarate/Fe²⁺-dependent oxygenase involved in translational regulation in Escherichia coli.
    van Staalduinen LM; Novakowski SK; Jia Z
    J Mol Biol; 2014 May; 426(9):1898-910. PubMed ID: 24530688
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The selectivity and inhibition of AlkB.
    Welford RW; Schlemminger I; McNeill LA; Hewitson KS; Schofield CJ
    J Biol Chem; 2003 Mar; 278(12):10157-61. PubMed ID: 12517755
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Integrative view of 2-oxoglutarate/Fe(II)-dependent oxygenase diversity and functions in bacteria.
    Jia B; Jia X; Kim KH; Jeon CO
    Biochim Biophys Acta Gen Subj; 2017 Feb; 1861(2):323-334. PubMed ID: 27919802
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Autocatalysed oxidative modifications to 2-oxoglutarate dependent oxygenases.
    Mantri M; Zhang Z; McDonough MA; Schofield CJ
    FEBS J; 2012 May; 279(9):1563-75. PubMed ID: 22251775
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Protein dynamics control the progression and efficiency of the catalytic reaction cycle of the Escherichia coli DNA-repair enzyme AlkB.
    Ergel B; Gill ML; Brown L; Yu B; Palmer AG; Hunt JF
    J Biol Chem; 2014 Oct; 289(43):29584-601. PubMed ID: 25043760
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Adventures in Defining Roles of Oxygenases in the Regulation of Protein Biosynthesis.
    Walport LJ; Schofield CJ
    Chem Rec; 2018 Dec; 18(12):1760-1781. PubMed ID: 30151867
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Preparation and characterization of the native iron(II)-containing DNA repair AlkB protein directly from Escherichia coli.
    Mishina Y; Chen LX; He C
    J Am Chem Soc; 2004 Dec; 126(51):16930-6. PubMed ID: 15612731
    [TBL] [Abstract][Full Text] [Related]  

  • 18. NMR studies of the non-haem Fe(II) and 2-oxoglutarate-dependent oxygenases.
    Mbenza NM; Vadakkedath PG; McGillivray DJ; Leung IKH
    J Inorg Biochem; 2017 Dec; 177():384-394. PubMed ID: 28893416
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Crystal structure of a clavaminate synthase-Fe(II)-2-oxoglutarate-substrate-NO complex: evidence for metal centered rearrangements.
    Zhang Z; Ren Js; Harlos K; McKinnon CH; Clifton IJ; Schofield CJ
    FEBS Lett; 2002 Apr; 517(1-3):7-12. PubMed ID: 12062399
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis of Novel Pyridine-Carboxylates as Small-Molecule Inhibitors of Human Aspartate/Asparagine-β-Hydroxylase.
    Brewitz L; Tumber A; Thalhammer A; Salah E; Christensen KE; Schofield CJ
    ChemMedChem; 2020 Jul; 15(13):1139-1149. PubMed ID: 32330361
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.