BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

288 related articles for article (PubMed ID: 22266653)

  • 1. The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.
    Zhang P; Lee H; Brunzelle JS; Couture JF
    Nucleic Acids Res; 2012 May; 40(9):4237-46. PubMed ID: 22266653
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.
    Alicea-Velázquez NL; Shinsky SA; Loh DM; Lee JH; Skalnik DG; Cosgrove MS
    J Biol Chem; 2016 Oct; 291(43):22357-22372. PubMed ID: 27563068
    [TBL] [Abstract][Full Text] [Related]  

  • 3. A conserved arginine-containing motif crucial for the assembly and enzymatic activity of the mixed lineage leukemia protein-1 core complex.
    Patel A; Vought VE; Dharmarajan V; Cosgrove MS
    J Biol Chem; 2008 Nov; 283(47):32162-75. PubMed ID: 18829457
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Unique Role of the WD-40 Repeat Protein 5 (WDR5) Subunit within the Mixed Lineage Leukemia 3 (MLL3) Histone Methyltransferase Complex.
    Shinsky SA; Cosgrove MS
    J Biol Chem; 2015 Oct; 290(43):25819-33. PubMed ID: 26324722
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.
    Dharmarajan V; Lee JH; Patel A; Skalnik DG; Cosgrove MS
    J Biol Chem; 2012 Aug; 287(33):27275-89. PubMed ID: 22665483
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structure of WDR5 bound to mixed lineage leukemia protein-1 peptide.
    Patel A; Dharmarajan V; Cosgrove MS
    J Biol Chem; 2008 Nov; 283(47):32158-61. PubMed ID: 18829459
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structural and biochemical insights into MLL1 core complex assembly.
    Avdic V; Zhang P; Lanouette S; Groulx A; Tremblay V; Brunzelle J; Couture JF
    Structure; 2011 Jan; 19(1):101-8. PubMed ID: 21220120
    [TBL] [Abstract][Full Text] [Related]  

  • 8. An Ash2L/RbBP5 heterodimer stimulates the MLL1 methyltransferase activity through coordinated substrate interactions with the MLL1 SET domain.
    Cao F; Chen Y; Cierpicki T; Liu Y; Basrur V; Lei M; Dou Y
    PLoS One; 2010 Nov; 5(11):e14102. PubMed ID: 21124902
    [TBL] [Abstract][Full Text] [Related]  

  • 9. WRAD: enabler of the SET1-family of H3K4 methyltransferases.
    Ernst P; Vakoc CR
    Brief Funct Genomics; 2012 May; 11(3):217-26. PubMed ID: 22652693
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Biochemical reconstitution and phylogenetic comparison of human SET1 family core complexes involved in histone methylation.
    Shinsky SA; Monteith KE; Viggiano S; Cosgrove MS
    J Biol Chem; 2015 Mar; 290(10):6361-75. PubMed ID: 25561738
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Structural basis of nucleosome recognition and modification by MLL methyltransferases.
    Xue H; Yao T; Cao M; Zhu G; Li Y; Yuan G; Chen Y; Lei M; Huang J
    Nature; 2019 Sep; 573(7774):445-449. PubMed ID: 31485071
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Fine-tuning the stimulation of MLL1 methyltransferase activity by a histone H3-based peptide mimetic.
    Avdic V; Zhang P; Lanouette S; Voronova A; Skerjanc I; Couture JF
    FASEB J; 2011 Mar; 25(3):960-7. PubMed ID: 21135039
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Identification and characterization of the human Set1B histone H3-Lys4 methyltransferase complex.
    Lee JH; Tate CM; You JS; Skalnik DG
    J Biol Chem; 2007 May; 282(18):13419-28. PubMed ID: 17355966
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Analysis of the binding of mixed lineage leukemia 1 (MLL1) and histone 3 peptides to WD repeat domain 5 (WDR5) for the design of inhibitors of the MLL1-WDR5 interaction.
    Karatas H; Townsend EC; Bernard D; Dou Y; Wang S
    J Med Chem; 2010 Jul; 53(14):5179-85. PubMed ID: 20575550
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A non-active-site SET domain surface crucial for the interaction of MLL1 and the RbBP5/Ash2L heterodimer within MLL family core complexes.
    Shinsky SA; Hu M; Vought VE; Ng SB; Bamshad MJ; Shendure J; Cosgrove MS
    J Mol Biol; 2014 Jun; 426(12):2283-99. PubMed ID: 24680668
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Diverse roles of WDR5-RbBP5-ASH2L-DPY30 (WRAD) complex in the functions of the SET1 histone methyltransferase family.
    Ali A; Tyagi S
    J Biosci; 2017 Mar; 42(1):155-159. PubMed ID: 28229975
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Targeting human SET1/MLL family of proteins.
    Vedadi M; Blazer L; Eram MS; Barsyte-Lovejoy D; Arrowsmith CH; Hajian T
    Protein Sci; 2017 Apr; 26(4):662-676. PubMed ID: 28160335
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Kinetics of the multitasking high-affinity Win binding site of WDR5 in restricted and unrestricted conditions.
    Imran A; Moyer BS; Canning AJ; Kalina D; Duncan TM; Moody KJ; Wolfe AJ; Cosgrove MS; Movileanu L
    Biochem J; 2021 Jun; 478(11):2145-2161. PubMed ID: 34032265
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Caenorhabditis elegans chromatin-associated proteins SET-2 and ASH-2 are differentially required for histone H3 Lys 4 methylation in embryos and adult germ cells.
    Xiao Y; Bedet C; Robert VJ; Simonet T; Dunkelbarger S; Rakotomalala C; Soete G; Korswagen HC; Strome S; Palladino F
    Proc Natl Acad Sci U S A; 2011 May; 108(20):8305-10. PubMed ID: 21527717
    [TBL] [Abstract][Full Text] [Related]  

  • 20. On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex.
    Patel A; Dharmarajan V; Vought VE; Cosgrove MS
    J Biol Chem; 2009 Sep; 284(36):24242-56. PubMed ID: 19556245
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.