BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

195 related articles for article (PubMed ID: 22278918)

  • 1. SHP-2 acts via ROCK to regulate the cardiac actin cytoskeleton.
    Langdon Y; Tandon P; Paden E; Duddy J; Taylor JM; Conlon FL
    Development; 2012 Mar; 139(5):948-57. PubMed ID: 22278918
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Inflammatory response in hematopoietic stem and progenitor cells triggered by activating SHP2 mutations evokes blood defects.
    Solman M; Blokzijl-Franke S; Piques F; Yan C; Yang Q; Strullu M; Kamel SM; Ak P; Bakkers J; Langenau DM; Cavé H; den Hertog J
    Elife; 2022 May; 11():. PubMed ID: 35535491
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Noonan and LEOPARD syndrome Shp2 variants induce heart displacement defects in zebrafish.
    Bonetti M; Paardekooper Overman J; Tessadori F; Noël E; Bakkers J; den Hertog J
    Development; 2014 May; 141(9):1961-70. PubMed ID: 24718990
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Hodgkin's lymphoma in a patient with Noonan syndrome with germ-line PTPN11 mutations.
    Lo FS; Kuo TT; Wang CJ; Kuo MT; Kuo MC
    Int J Hematol; 2008 Oct; 88(3):287-290. PubMed ID: 18758896
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Functional analysis of PTPN11/SHP-2 mutants identified in Noonan syndrome and childhood leukemia.
    Niihori T; Aoki Y; Ohashi H; Kurosawa K; Kondoh T; Ishikiriyama S; Kawame H; Kamasaki H; Yamanaka T; Takada F; Nishio K; Sakurai M; Tamai H; Nagashima T; Suzuki Y; Kure S; Fujii K; Imaizumi M; Matsubara Y
    J Hum Genet; 2005; 50(4):192-202. PubMed ID: 15834506
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Noonan syndrome/leukemia-associated gain-of-function mutations in SHP-2 phosphatase (PTPN11) enhance cell migration and angiogenesis.
    Wang S; Yu WM; Zhang W; McCrae KR; Neel BG; Qu CK
    J Biol Chem; 2009 Jan; 284(2):913-20. PubMed ID: 19008228
    [TBL] [Abstract][Full Text] [Related]  

  • 7. SHP-2 is required for the maintenance of cardiac progenitors.
    Langdon YG; Goetz SC; Berg AE; Swanik JT; Conlon FL
    Development; 2007 Nov; 134(22):4119-30. PubMed ID: 17928416
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Gain-of-function/Noonan syndrome SHP-2/Ptpn11 mutants enhance calcium oscillations and impair NFAT signaling.
    Uhlén P; Burch PM; Zito CI; Estrada M; Ehrlich BE; Bennett AM
    Proc Natl Acad Sci U S A; 2006 Feb; 103(7):2160-5. PubMed ID: 16461457
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Occurrence of acute lymphoblastic leukemia and juvenile myelomonocytic leukemia in a patient with Noonan syndrome carrying the germline PTPN11 mutation p.E139D.
    Pauli S; Steinemann D; Dittmann K; Wienands J; Shoukier M; Möschner M; Burfeind P; Manukjan G; Göhring G; Escherich G
    Am J Med Genet A; 2012 Mar; 158A(3):652-8. PubMed ID: 22315187
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Noonan syndrome-associated SHP-2/Ptpn11 mutants enhance SIRPalpha and PZR tyrosyl phosphorylation and promote adhesion-mediated ERK activation.
    Eminaga S; Bennett AM
    J Biol Chem; 2008 May; 283(22):15328-38. PubMed ID: 18378677
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia.
    Bentires-Alj M; Paez JG; David FS; Keilhack H; Halmos B; Naoki K; Maris JM; Richardson A; Bardelli A; Sugarbaker DJ; Richards WG; Du J; Girard L; Minna JD; Loh ML; Fisher DE; Velculescu VE; Vogelstein B; Meyerson M; Sellers WR; Neel BG
    Cancer Res; 2004 Dec; 64(24):8816-20. PubMed ID: 15604238
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Shp2 knockdown and Noonan/LEOPARD mutant Shp2-induced gastrulation defects.
    Jopling C; van Geemen D; den Hertog J
    PLoS Genet; 2007 Dec; 3(12):e225. PubMed ID: 18159945
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome.
    Tartaglia M; Mehler EL; Goldberg R; Zampino G; Brunner HG; Kremer H; van der Burgt I; Crosby AH; Ion A; Jeffery S; Kalidas K; Patton MA; Kucherlapati RS; Gelb BD
    Nat Genet; 2001 Dec; 29(4):465-8. PubMed ID: 11704759
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Mediating ERK 1/2 signaling rescues congenital heart defects in a mouse model of Noonan syndrome.
    Nakamura T; Colbert M; Krenz M; Molkentin JD; Hahn HS; Dorn GW; Robbins J
    J Clin Invest; 2007 Aug; 117(8):2123-32. PubMed ID: 17641779
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Mutational analysis of the PTPN11 gene in Egyptian patients with Noonan syndrome.
    Essawi ML; Ismail MF; Afifi HH; Kobesiy MM; El Kotoury A; Barakat MM
    J Formos Med Assoc; 2013 Nov; 112(11):707-12. PubMed ID: 24183200
    [TBL] [Abstract][Full Text] [Related]  

  • 16. PTPN11 mutations are associated with mild growth hormone resistance in individuals with Noonan syndrome.
    Binder G; Neuer K; Ranke MB; Wittekindt NE
    J Clin Endocrinol Metab; 2005 Sep; 90(9):5377-81. PubMed ID: 15985475
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis.
    Loh ML; Vattikuti S; Schubbert S; Reynolds MG; Carlson E; Lieuw KH; Cheng JW; Lee CM; Stokoe D; Bonifas JM; Curtiss NP; Gotlib J; Meshinchi S; Le Beau MM; Emanuel PD; Shannon KM
    Blood; 2004 Mar; 103(6):2325-31. PubMed ID: 14644997
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Mutations in RIT1 cause Noonan syndrome with possible juvenile myelomonocytic leukemia but are not involved in acute lymphoblastic leukemia.
    Cavé H; Caye A; Ghedira N; Capri Y; Pouvreau N; Fillot N; Trimouille A; Vignal C; Fenneteau O; Alembik Y; Alessandri JL; Blanchet P; Boute O; Bouvagnet P; David A; Dieux Coeslier A; Doray B; Dulac O; Drouin-Garraud V; Gérard M; Héron D; Isidor B; Lacombe D; Lyonnet S; Perrin L; Rio M; Roume J; Sauvion S; Toutain A; Vincent-Delorme C; Willems M; Baumann C; Verloes A
    Eur J Hum Genet; 2016 Aug; 24(8):1124-31. PubMed ID: 26757980
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Noonan syndrome and related disorders: genetics and pathogenesis.
    Tartaglia M; Gelb BD
    Annu Rev Genomics Hum Genet; 2005; 6():45-68. PubMed ID: 16124853
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Myeloproliferative disorder in Noonan syndrome.
    Bastida P; García-Miñaúr S; Ezquieta B; Dapena JL; Sanchez de Toledo J
    J Pediatr Hematol Oncol; 2011 Jan; 33(1):e43-5. PubMed ID: 20829714
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.