BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

322 related articles for article (PubMed ID: 22284678)

  • 1. Importin 7 and exportin 1 link c-Myc and p53 to regulation of ribosomal biogenesis.
    Golomb L; Bublik DR; Wilder S; Nevo R; Kiss V; Grabusic K; Volarevic S; Oren M
    Mol Cell; 2012 Jan; 45(2):222-32. PubMed ID: 22284678
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Ribosomal Biogenesis and Translational Flux Inhibition by the Selective Inhibitor of Nuclear Export (SINE) XPO1 Antagonist KPT-185.
    Tabe Y; Kojima K; Yamamoto S; Sekihara K; Matsushita H; Davis RE; Wang Z; Ma W; Ishizawa J; Kazuno S; Kauffman M; Shacham S; Fujimura T; Ueno T; Miida T; Andreeff M
    PLoS One; 2015; 10(9):e0137210. PubMed ID: 26340096
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Perturbation of RNA Polymerase I transcription machinery by ablation of HEATR1 triggers the RPL5/RPL11-MDM2-p53 ribosome biogenesis stress checkpoint pathway in human cells.
    Turi Z; Senkyrikova M; Mistrik M; Bartek J; Moudry P
    Cell Cycle; 2018; 17(1):92-101. PubMed ID: 29143558
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Oncogenic MYC Induces the Impaired Ribosome Biogenesis Checkpoint and Stabilizes p53 Independent of Increased Ribosome Content.
    Morcelle C; Menoyo S; Morón-Duran FD; Tauler A; Kozma SC; Thomas G; Gentilella A
    Cancer Res; 2019 Sep; 79(17):4348-4359. PubMed ID: 31292158
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress.
    Bursać S; Brdovčak MC; Pfannkuchen M; Orsolić I; Golomb L; Zhu Y; Katz C; Daftuar L; Grabušić K; Vukelić I; Filić V; Oren M; Prives C; Volarevic S
    Proc Natl Acad Sci U S A; 2012 Dec; 109(50):20467-72. PubMed ID: 23169665
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Ribosomal protein L4 is a novel regulator of the MDM2-p53 loop.
    He X; Li Y; Dai MS; Sun XX
    Oncotarget; 2016 Mar; 7(13):16217-26. PubMed ID: 26908445
    [TBL] [Abstract][Full Text] [Related]  

  • 7. An ARF-independent c-MYC-activated tumor suppression pathway mediated by ribosomal protein-Mdm2 Interaction.
    Macias E; Jin A; Deisenroth C; Bhat K; Mao H; Lindström MS; Zhang Y
    Cancer Cell; 2010 Sep; 18(3):231-43. PubMed ID: 20832751
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Perturbation of 60 S ribosomal biogenesis results in ribosomal protein L5- and L11-dependent p53 activation.
    Sun XX; Wang YG; Xirodimas DP; Dai MS
    J Biol Chem; 2010 Aug; 285(33):25812-21. PubMed ID: 20554519
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Ribosomal proteins L5 and L11 co-operatively inactivate c-Myc via RNA-induced silencing complex.
    Liao JM; Zhou X; Gatignol A; Lu H
    Oncogene; 2014 Oct; 33(41):4916-23. PubMed ID: 24141778
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Disruption of the RP-MDM2-p53 pathway accelerates APC loss-induced colorectal tumorigenesis.
    Liu S; Tackmann NR; Yang J; Zhang Y
    Oncogene; 2017 Mar; 36(10):1374-1383. PubMed ID: 27617574
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Absence of nucleolar disruption after impairment of 40S ribosome biogenesis reveals an rpL11-translation-dependent mechanism of p53 induction.
    Fumagalli S; Di Cara A; Neb-Gulati A; Natt F; Schwemberger S; Hall J; Babcock GF; Bernardi R; Pandolfi PP; Thomas G
    Nat Cell Biol; 2009 Apr; 11(4):501-8. PubMed ID: 19287375
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Activation of the tumor suppressor p53 upon impairment of ribosome biogenesis.
    Bursac S; Brdovcak MC; Donati G; Volarevic S
    Biochim Biophys Acta; 2014 Jun; 1842(6):817-30. PubMed ID: 24514102
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Aberrant ribosome biogenesis activates c-Myc and ASK1 pathways resulting in p53-dependent G1 arrest.
    Kim HD; Kim TS; Kim J
    Oncogene; 2011 Jul; 30(30):3317-27. PubMed ID: 21383696
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Ribosomal protein S14 unties the MDM2-p53 loop upon ribosomal stress.
    Zhou X; Hao Q; Liao J; Zhang Q; Lu H
    Oncogene; 2013 Jan; 32(3):388-96. PubMed ID: 22391559
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway.
    Zhang Y; Wolf GW; Bhat K; Jin A; Allio T; Burkhart WA; Xiong Y
    Mol Cell Biol; 2003 Dec; 23(23):8902-12. PubMed ID: 14612427
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Interleukin 6 downregulates p53 expression and activity by stimulating ribosome biogenesis: a new pathway connecting inflammation to cancer.
    Brighenti E; Calabrese C; Liguori G; Giannone FA; Trerè D; Montanaro L; Derenzini M
    Oncogene; 2014 Aug; 33(35):4396-406. PubMed ID: 24531714
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Ribosomal protein L11 associates with c-Myc at 5 S rRNA and tRNA genes and regulates their expression.
    Dai MS; Sun XX; Lu H
    J Biol Chem; 2010 Apr; 285(17):12587-94. PubMed ID: 20194507
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Acrolein preferentially damages nucleolus eliciting ribosomal stress and apoptosis in human cancer cells.
    Wang HT; Chen TY; Weng CW; Yang CH; Tang MS
    Oncotarget; 2016 Dec; 7(49):80450-80464. PubMed ID: 27741518
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Cancer-associated mutations in the ribosomal protein L5 gene dysregulate the HDM2/p53-mediated ribosome biogenesis checkpoint.
    Oršolić I; Bursać S; Jurada D; Drmić Hofman I; Dembić Z; Bartek J; Mihalek I; Volarević S
    Oncogene; 2020 Apr; 39(17):3443-3457. PubMed ID: 32108164
    [TBL] [Abstract][Full Text] [Related]  

  • 20. mTOR inhibitors blunt the p53 response to nucleolar stress by regulating RPL11 and MDM2 levels.
    Goudarzi KM; Nistér M; Lindström MS
    Cancer Biol Ther; 2014; 15(11):1499-514. PubMed ID: 25482947
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 17.