BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

254 related articles for article (PubMed ID: 22294159)

  • 1. Effect of heterozygous deletion of WNK1 on the WNK-OSR1/ SPAK-NCC/NKCC1/NKCC2 signal cascade in the kidney and blood vessels.
    Susa K; Kita S; Iwamoto T; Yang SS; Lin SH; Ohta A; Sohara E; Rai T; Sasaki S; Alessi DR; Uchida S
    Clin Exp Nephrol; 2012 Aug; 16(4):530-8. PubMed ID: 22294159
    [TBL] [Abstract][Full Text] [Related]  

  • 2. WNK4 is indispensable for the pathogenesis of pseudohypoaldosteronism type II caused by mutant KLHL3.
    Susa K; Sohara E; Takahashi D; Okado T; Rai T; Uchida S
    Biochem Biophys Res Commun; 2017 Sep; 491(3):727-732. PubMed ID: 28743496
    [TBL] [Abstract][Full Text] [Related]  

  • 3. SPAK deficiency corrects pseudohypoaldosteronism II caused by WNK4 mutation.
    Chu PY; Cheng CJ; Wu YC; Fang YW; Chau T; Uchida S; Sasaki S; Yang SS; Lin SH
    PLoS One; 2013; 8(9):e72969. PubMed ID: 24039833
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on the WNK-OSR1/SPAK kinase cascade.
    Chiga M; Rafiqi FH; Alessi DR; Sohara E; Ohta A; Rai T; Sasaki S; Uchida S
    J Cell Sci; 2011 May; 124(Pt 9):1391-5. PubMed ID: 21486947
    [TBL] [Abstract][Full Text] [Related]  

  • 5. WNK-SPAK-NCC cascade revisited: WNK1 stimulates the activity of the Na-Cl cotransporter via SPAK, an effect antagonized by WNK4.
    Chávez-Canales M; Zhang C; Soukaseum C; Moreno E; Pacheco-Alvarez D; Vidal-Petiot E; Castañeda-Bueno M; Vázquez N; Rojas-Vega L; Meermeier NP; Rogers S; Jeunemaitre X; Yang CL; Ellison DH; Gamba G; Hadchouel J
    Hypertension; 2014 Nov; 64(5):1047-53. PubMed ID: 25113964
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Phosphatidylinositol 3-kinase/Akt signaling pathway activates the WNK-OSR1/SPAK-NCC phosphorylation cascade in hyperinsulinemic db/db mice.
    Nishida H; Sohara E; Nomura N; Chiga M; Alessi DR; Rai T; Sasaki S; Uchida S
    Hypertension; 2012 Oct; 60(4):981-90. PubMed ID: 22949526
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Downregulation of NCC and NKCC2 cotransporters by kidney-specific WNK1 revealed by gene disruption and transgenic mouse models.
    Liu Z; Xie J; Wu T; Truong T; Auchus RJ; Huang CL
    Hum Mol Genet; 2011 Mar; 20(5):855-66. PubMed ID: 21131289
    [TBL] [Abstract][Full Text] [Related]  

  • 8. SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation.
    Thastrup JO; Rafiqi FH; Vitari AC; Pozo-Guisado E; Deak M; Mehellou Y; Alessi DR
    Biochem J; 2012 Jan; 441(1):325-37. PubMed ID: 22032326
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction.
    Ohta A; Schumacher FR; Mehellou Y; Johnson C; Knebel A; Macartney TJ; Wood NT; Alessi DR; Kurz T
    Biochem J; 2013 Apr; 451(1):111-22. PubMed ID: 23387299
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1.
    Vitari AC; Thastrup J; Rafiqi FH; Deak M; Morrice NA; Karlsson HK; Alessi DR
    Biochem J; 2006 Jul; 397(1):223-31. PubMed ID: 16669787
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Impaired phosphorylation of Na(+)-K(+)-2Cl(-) cotransporter by oxidative stress-responsive kinase-1 deficiency manifests hypotension and Bartter-like syndrome.
    Lin SH; Yu IS; Jiang ST; Lin SW; Chu P; Chen A; Sytwu HK; Sohara E; Uchida S; Sasaki S; Yang SS
    Proc Natl Acad Sci U S A; 2011 Oct; 108(42):17538-43. PubMed ID: 21972418
    [TBL] [Abstract][Full Text] [Related]  

  • 12. WNK bodies cluster WNK4 and SPAK/OSR1 to promote NCC activation in hypokalemia.
    Thomson MN; Cuevas CA; Bewarder TM; Dittmayer C; Miller LN; Si J; Cornelius RJ; Su XT; Yang CL; McCormick JA; Hadchouel J; Ellison DH; Bachmann S; Mutig K
    Am J Physiol Renal Physiol; 2020 Jan; 318(1):F216-F228. PubMed ID: 31736353
    [TBL] [Abstract][Full Text] [Related]  

  • 13. WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.
    Moriguchi T; Urushiyama S; Hisamoto N; Iemura S; Uchida S; Natsume T; Matsumoto K; Shibuya H
    J Biol Chem; 2005 Dec; 280(52):42685-93. PubMed ID: 16263722
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Cotransporters, WNKs and hypertension: an update.
    Flatman PW
    Curr Opin Nephrol Hypertens; 2008 Mar; 17(2):186-92. PubMed ID: 18277153
    [TBL] [Abstract][Full Text] [Related]  

  • 15. WNK kinases regulate thiazide-sensitive Na-Cl cotransport.
    Yang CL; Angell J; Mitchell R; Ellison DH
    J Clin Invest; 2003 Apr; 111(7):1039-45. PubMed ID: 12671053
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1.
    Richardson C; Rafiqi FH; Karlsson HK; Moleleki N; Vandewalle A; Campbell DG; Morrice NA; Alessi DR
    J Cell Sci; 2008 Mar; 121(Pt 5):675-84. PubMed ID: 18270262
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Interactions with WNK (with no lysine) family members regulate oxidative stress response 1 and ion co-transporter activity.
    Sengupta S; Tu SW; Wedin K; Earnest S; Stippec S; Luby-Phelps K; Cobb MH
    J Biol Chem; 2012 Nov; 287(45):37868-79. PubMed ID: 22989884
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Impaired degradation of WNK1 and WNK4 kinases causes PHAII in mutant KLHL3 knock-in mice.
    Susa K; Sohara E; Rai T; Zeniya M; Mori Y; Mori T; Chiga M; Nomura N; Nishida H; Takahashi D; Isobe K; Inoue Y; Takeishi K; Takeda N; Sasaki S; Uchida S
    Hum Mol Genet; 2014 Oct; 23(19):5052-60. PubMed ID: 24821705
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Decreased KLHL3 expression is involved in the activation of WNK-OSR1/SPAK-NCC cascade in type 1 diabetic mice.
    Guo Q; Zhang Y; Jiang GR; Zhang C
    Pflugers Arch; 2021 Feb; 473(2):185-196. PubMed ID: 33432425
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Dysregulation of the WNK4-SPAK/OSR1 pathway has a minor effect on baseline NKCC2 phosphorylation.
    Maeoka Y; Nguyen LT; Sharma A; Cornelius RJ; Su XT; Gutierrez MR; Carbajal-Contreras H; Castañeda-Bueno M; Gamba G; McCormick JA
    Am J Physiol Renal Physiol; 2024 Jan; 326(1):F39-F56. PubMed ID: 37881876
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.