These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

128 related articles for article (PubMed ID: 2231594)

  • 21. RG 12561 (dalvastatin): a novel synthetic inhibitor of HMG-CoA reductase and cholesterol-lowering agent.
    Amin D; Gustafson SK; Weinacht JM; Cornell SA; Neuenschwander K; Kosmider B; Scotese AC; Regan JR; Perrone MH
    Pharmacology; 1993; 46(1):13-22. PubMed ID: 8434028
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Inhibition of cholesterol synthesis ex vivo and in vivo by fluvastatin, a new inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase.
    Yamamoto A; Itoh S; Hoshi K; Ichihara K
    Experientia; 1995 Mar; 51(3):223-6. PubMed ID: 7698284
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Synthesis and biological activity of new HMG-CoA reductase inhibitors. 2. Derivatives of 7-(1H-pyrrol-3-yl)-substituted-3,5-dihydroxyhept-6(E)-enoic (-heptanoic) acids.
    Jendralla H; Baader E; Bartmann W; Beck G; Bergmann A; Granzer E; von Kerekjarto B; Kesseler K; Krause R; Schubert W
    J Med Chem; 1990 Jan; 33(1):61-70. PubMed ID: 2153213
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Influence of pravastatin, a specific inhibitor of HMG-CoA reductase, on hepatic metabolism of cholesterol.
    Reihnér E; Rudling M; Ståhlberg D; Berglund L; Ewerth S; Björkhem I; Einarsson K; Angelin B
    N Engl J Med; 1990 Jul; 323(4):224-8. PubMed ID: 2114543
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Lack of correlation between the rate of cholesterol biosynthesis and the activity of 3-hydroxy-3-methylgutaryl coenzyme A reductase in rats and in fibroblasts treated with ML-236B.
    Bensch WR; Ingebritsen TS; Diller ER
    Biochem Biophys Res Commun; 1978 May; 82(1):247-54. PubMed ID: 666838
    [No Abstract]   [Full Text] [Related]  

  • 26. Synthesis and biological activity of new HMG-CoA reductase inhibitors. 1. Lactones of pyridine- and pyrimidine-substituted 3,5-dihydroxy-6-heptenoic (-heptanoic) acids.
    Beck G; Kesseler K; Baader E; Bartmann W; Bergmann A; Granzer E; Jendralla H; von Kerekjarto B; Krause R; Paulus E
    J Med Chem; 1990 Jan; 33(1):52-60. PubMed ID: 2296036
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Inhibitors of cholesterol biosynthesis increase hepatic low-density lipoprotein receptor protein degradation.
    Ness GC; Zhao Z; Lopez D
    Arch Biochem Biophys; 1996 Jan; 325(2):242-8. PubMed ID: 8561503
    [TBL] [Abstract][Full Text] [Related]  

  • 28. 3-Hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors. 7. Modification of the hexahydronaphthalene moiety of simvastatin: 5-oxygenated and 5-oxa derivatives.
    Duggan ME; Alberts AW; Bostedor R; Chao YS; Germershausen JI; Gilfillan JL; Halczenko W; Hartman GD; Hunt V; Imagire JS
    J Med Chem; 1991 Aug; 34(8):2489-95. PubMed ID: 1875346
    [TBL] [Abstract][Full Text] [Related]  

  • 29. The role of substrate supply in the regulation of cholesterol biosynthesis in rat hepatocytes.
    Pullinger CR; Gibbons GF
    Biochem J; 1983 Mar; 210(3):625-32. PubMed ID: 6870798
    [TBL] [Abstract][Full Text] [Related]  

  • 30. The synergistic hypocholesterolemic activity of the potent cholesterol absorption inhibitor, ezetimibe, in combination with 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors in dogs.
    Davis HR; Pula KK; Alton KB; Burrier RE; Watkins RW
    Metabolism; 2001 Oct; 50(10):1234-41. PubMed ID: 11586500
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Relationships between lipophilicity and biological activities in a series of indoline-based anti-oxidative acyl-CoA:cholesterol acyltransferase (ACAT) inhibitors.
    Takahashi K; Kunishiro K; Kasai M; Miike T; Kurahashi K; Shirahase H
    Arzneimittelforschung; 2008; 58(12):666-72. PubMed ID: 19202739
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Hepatic responses to inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase: a comparison of atorvastatin and simvastatin.
    Bergstrom JD; Bostedor RG; Rew DJ; Geissler WM; Wright SD; Chao YS
    Biochim Biophys Acta; 1998 Jan; 1389(3):213-21. PubMed ID: 9512650
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Regulation of HMG-CoA reductase, apoprotein-B and LDL receptor gene expression by the hypocholesterolemic drugs simvastatin and ciprofibrate in Hep G2, human and rat hepatocytes.
    Qin W; Infante J; Wang SR; Infante R
    Biochim Biophys Acta; 1992 Jul; 1127(1):57-66. PubMed ID: 1627634
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Novel indoline-based acyl-CoA:cholesterol acyltransferase inhibitor with antiperoxidative activity: improvement of physicochemical properties and biological activities by introduction of carboxylic acid.
    Takahashi K; Kasai M; Ohta M; Shoji Y; Kunishiro K; Kanda M; Kurahashi K; Shirahase H
    J Med Chem; 2008 Aug; 51(15):4823-33. PubMed ID: 18620381
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Structural mechanism for statin inhibition of HMG-CoA reductase.
    Istvan ES; Deisenhofer J
    Science; 2001 May; 292(5519):1160-4. PubMed ID: 11349148
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Comparative evaluation of the safety and efficacy of HMG-CoA reductase inhibitor monotherapy in the treatment of primary hypercholesterolemia.
    Hsu I; Spinler SA; Johnson NE
    Ann Pharmacother; 1995; 29(7-8):743-59. PubMed ID: 8520093
    [TBL] [Abstract][Full Text] [Related]  

  • 37. RPR 107393, a potent squalene synthase inhibitor and orally effective cholesterol-lowering agent: comparison with inhibitors of HMG-CoA reductase.
    Amin D; Rutledge RZ; Needle SN; Galczenski HF; Neuenschwander K; Scotese AC; Maguire MP; Bush RC; Hele DJ; Bilder GE; Perrone MH
    J Pharmacol Exp Ther; 1997 May; 281(2):746-52. PubMed ID: 9152381
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Hypocholesterolemic indole-2-carboxylic acids.
    Kariya T; Grisar JM; Wiech NL; Blohm TR
    J Med Chem; 1972 Jun; 15(6):659-62. PubMed ID: 5030934
    [No Abstract]   [Full Text] [Related]  

  • 39. Regulation of rat liver hydroxymethylglutaryl coenzyme A reductase by a new class of noncompetitive inhibitors. Effects of dichloroacetate and related carboxylic acids on enzyme activity.
    Stacpoole PW; Harwood HJ; Varnado CE
    J Clin Invest; 1983 Nov; 72(5):1575-85. PubMed ID: 6630519
    [TBL] [Abstract][Full Text] [Related]  

  • 40. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 9. The synthesis and biological evaluation of novel simvastatin analogs.
    Hartman GD; Halczenko W; Duggan ME; Imagire JS; Smith RL; Pitzenberger SM; Fitzpatrick SL; Alberts AW; Bostedor R; Chao YS
    J Med Chem; 1992 Oct; 35(21):3813-21. PubMed ID: 1433193
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 7.