BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

258 related articles for article (PubMed ID: 22342625)

  • 1. Structure-based virtual screening approach to the discovery of p38 MAP kinase inhibitors.
    Choi H; Park HJ; Shin JC; Ko HS; Lee JK; Lee S; Park H; Hong S
    Bioorg Med Chem Lett; 2012 Mar; 22(6):2195-9. PubMed ID: 22342625
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structure-based virtual screening approach to the discovery of phosphoinositide 3-kinase alpha inhibitors.
    Park H; Choi H; Hong S; Kim D; Oh DS; Hong S
    Bioorg Med Chem Lett; 2011 Apr; 21(7):2021-4. PubMed ID: 21354792
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Discovery of MEK/PI3K dual inhibitor via structure-based virtual screening.
    Park H; Lee S; Hong S
    Bioorg Med Chem Lett; 2012 Aug; 22(15):4946-50. PubMed ID: 22771009
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Identification of novel BRAF kinase inhibitors with structure-based virtual screening.
    Park H; Choi H; Hong S; Hong S
    Bioorg Med Chem Lett; 2011 Oct; 21(19):5753-6. PubMed ID: 21873050
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Identification of novel inhibitors of tropomyosin-related kinase A through the structure-based virtual screening with homology-modeled protein structure.
    Park H; Chi O; Kim J; Hong S
    J Chem Inf Model; 2011 Nov; 51(11):2986-93. PubMed ID: 22017333
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structure-based virtual screening approach to the discovery of novel PTPMT1 phosphatase inhibitors.
    Park H; Kim SY; Kyung A; Yoon TS; Ryu SE; Jeong DG
    Bioorg Med Chem Lett; 2012 Jan; 22(2):1271-5. PubMed ID: 22115589
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Discovery of potent inhibitors of receptor protein tyrosine phosphatase sigma through the structure-based virtual screening.
    Park H; Chien PN; Ryu SE
    Bioorg Med Chem Lett; 2012 Oct; 22(20):6333-7. PubMed ID: 22989533
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Virtual screening and biochemical evaluation to identify new inhibitors of mammalian target of rapamycin (mTOR).
    Park H; Choe H; Hong S
    Bioorg Med Chem Lett; 2014 Feb; 24(3):835-8. PubMed ID: 24393580
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Identification of potent VHZ phosphatase inhibitors with structure-based virtual screening.
    Park H; Park SY; Oh JJ; Ryu SE
    J Biomol Screen; 2013 Feb; 18(2):226-31. PubMed ID: 23042075
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structure-based de novo design and synthesis of aminothiazole-based p38 MAP kinase inhibitors.
    Park H; Lee S; Hong S
    Bioorg Med Chem Lett; 2015 Sep; 25(18):3784-7. PubMed ID: 26259807
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Part 1: Structure-Activity Relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38alpha mitogen-activated protein kinase.
    Wurz RP; Pettus LH; Xu S; Henkle B; Sherman L; Plant M; Miner K; McBride H; Wong LM; Saris CJ; Lee MR; Chmait S; Mohr C; Hsieh F; Tasker AS
    Bioorg Med Chem Lett; 2009 Aug; 19(16):4724-8. PubMed ID: 19574047
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Homology modeling and virtual screening approaches to identify potent inhibitors of slingshot phosphatase 1.
    Park H; Park SY; Ryu SE
    J Mol Graph Model; 2013 Feb; 39():65-70. PubMed ID: 23220283
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Discovery and characterization of non-ATP site inhibitors of the mitogen activated protein (MAP) kinases.
    Comess KM; Sun C; Abad-Zapatero C; Goedken ER; Gum RJ; Borhani DW; Argiriadi M; Groebe DR; Jia Y; Clampit JE; Haasch DL; Smith HT; Wang S; Song D; Coen ML; Cloutier TE; Tang H; Cheng X; Quinn C; Liu B; Xin Z; Liu G; Fry EH; Stoll V; Ng TI; Banach D; Marcotte D; Burns DJ; Calderwood DJ; Hajduk PJ
    ACS Chem Biol; 2011 Mar; 6(3):234-44. PubMed ID: 21090814
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Discovery of 5-substituted-N-arylpyridazinones as inhibitors of p38 MAP kinase.
    Jerome KD; Hepperle ME; Walker JK; Xing L; Devraj RV; Benson AG; Baldus JE; Selness SR
    Bioorg Med Chem Lett; 2010 May; 20(10):3146-9. PubMed ID: 20395140
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Implications for selectivity of 3,4-diarylquinolinones as p38alphaMAP kinase inhibitors.
    Peifer C; Urich R; Schattel V; Abadleh M; Röttig M; Kohlbacher O; Laufer S
    Bioorg Med Chem Lett; 2008 Feb; 18(4):1431-5. PubMed ID: 18207396
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Identification of novel inhibitors of extracellular signal-regulated kinase 2 based on the structure-based virtual screening.
    Park H; Bahn YJ; Jeong DG; Woo EJ; Kwon JS; Ryu SE
    Bioorg Med Chem Lett; 2008 Oct; 18(20):5372-6. PubMed ID: 18835158
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Design of potent and selective 2-aminobenzimidazole-based p38alpha MAP kinase inhibitors with excellent in vivo efficacy.
    de Dios A; Shih C; López de Uralde B; Sánchez C; del Prado M; Martín Cabrejas LM; Pleite S; Blanco-Urgoiti J; Lorite MJ; Nevill CR; Bonjouklian R; York J; Vieth M; Wang Y; Magnus N; Campbell RM; Anderson BD; McCann DJ; Giera DD; Lee PA; Schultz RM; Li LC; Johnson LM; Wolos JA
    J Med Chem; 2005 Apr; 48(7):2270-3. PubMed ID: 15801819
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Structure-based de novo design and biochemical evaluation of novel BRAF kinase inhibitors.
    Park H; Jeong Y; Hong S
    Bioorg Med Chem Lett; 2012 Jan; 22(2):1027-30. PubMed ID: 22196123
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis and biological activity of pyridopyridazin-6-one p38 MAP kinase inhibitors. Part 1.
    Tynebor RM; Chen MH; Natarajan SR; O'Neill EA; Thompson JE; Fitzgerald CE; O'Keefe SJ; Doherty JB
    Bioorg Med Chem Lett; 2011 Jan; 21(1):411-6. PubMed ID: 21084192
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Biological evaluation and structural determinants of p38α mitogen-activated-protein kinase and c-Jun-N-terminal kinase 3 inhibition by flavonoids.
    Goettert M; Schattel V; Koch P; Merfort I; Laufer S
    Chembiochem; 2010 Dec; 11(18):2579-88. PubMed ID: 21108268
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.