These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

292 related articles for article (PubMed ID: 22345605)

  • 1. Rates and fitness consequences of new mutations in humans.
    Keightley PD
    Genetics; 2012 Feb; 190(2):295-304. PubMed ID: 22345605
    [TBL] [Abstract][Full Text] [Related]  

  • 2. A resolution of the mutation load paradox in humans.
    Lesecque Y; Keightley PD; Eyre-Walker A
    Genetics; 2012 Aug; 191(4):1321-30. PubMed ID: 22661324
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Estimate of the mutation rate per nucleotide in humans.
    Nachman MW; Crowell SL
    Genetics; 2000 Sep; 156(1):297-304. PubMed ID: 10978293
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Direct estimation of per nucleotide and genomic deleterious mutation rates in Drosophila.
    Haag-Liautard C; Dorris M; Maside X; Macaskill S; Halligan DL; Houle D; Charlesworth B; Keightley PD
    Nature; 2007 Jan; 445(7123):82-5. PubMed ID: 17203060
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Selective constraint, background selection, and mutation accumulation variability within and between human populations.
    Hodgkinson A; Casals F; Idaghdour Y; Grenier JC; Hernandez RD; Awadalla P
    BMC Genomics; 2013 Jul; 14():495. PubMed ID: 23875710
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Accelerating Mutational Load Is Not Due to Synergistic Epistasis or Mutator Alleles in Mutation Accumulation Lines of Yeast.
    Jasmin JN; Lenormand T
    Genetics; 2016 Feb; 202(2):751-63. PubMed ID: 26596348
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Extreme purifying selection against point mutations in the human genome.
    Dukler N; Mughal MR; Ramani R; Huang YF; Siepel A
    Nat Commun; 2022 Jul; 13(1):4312. PubMed ID: 35879308
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Functional constraints and frequency of deleterious mutations in noncoding DNA of rodents.
    Keightley PD; Gaffney DJ
    Proc Natl Acad Sci U S A; 2003 Nov; 100(23):13402-6. PubMed ID: 14597721
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Accumulation of spontaneous mutations in the ciliate Tetrahymena thermophila.
    Long HA; Paixão T; Azevedo RB; Zufall RA
    Genetics; 2013 Oct; 195(2):527-40. PubMed ID: 23934880
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Fitness decline in spontaneous mutation accumulation lines of Caenorhabditis elegans with varying effective population sizes.
    Katju V; Packard LB; Bu L; Keightley PD; Bergthorsson U
    Evolution; 2015 Jan; 69(1):104-16. PubMed ID: 25338758
    [TBL] [Abstract][Full Text] [Related]  

  • 11. High genomic deleterious mutation rates in hominids.
    Eyre-Walker A; Keightley PD
    Nature; 1999 Jan; 397(6717):344-7. PubMed ID: 9950425
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Approximation to the distribution of fitness effects across functional categories in human segregating polymorphisms.
    Racimo F; Schraiber JG
    PLoS Genet; 2014 Nov; 10(11):e1004697. PubMed ID: 25375159
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Direct estimate of the spontaneous germ line mutation rate in African green monkeys.
    Pfeifer SP
    Evolution; 2017 Dec; 71(12):2858-2870. PubMed ID: 29068052
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Mutational Load and the Functional Fraction of the Human Genome.
    Galeota-Sprung B; Sniegowski P; Ewens W
    Genome Biol Evol; 2020 Apr; 12(4):273-281. PubMed ID: 32108234
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The Role of Deleterious Substitutions in Crop Genomes.
    Kono TJ; Fu F; Mohammadi M; Hoffman PJ; Liu C; Stupar RM; Smith KP; Tiffin P; Fay JC; Morrell PL
    Mol Biol Evol; 2016 Sep; 33(9):2307-17. PubMed ID: 27301592
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Negative selection in humans and fruit flies involves synergistic epistasis.
    Sohail M; Vakhrusheva OA; Sul JH; Pulit SL; Francioli LC; ; ; van den Berg LH; Veldink JH; de Bakker PIW; Bazykin GA; Kondrashov AS; Sunyaev SR
    Science; 2017 May; 356(6337):539-542. PubMed ID: 28473589
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Distributions of selectively constrained sites and deleterious mutation rates in the hominid and murid genomes.
    Eory L; Halligan DL; Keightley PD
    Mol Biol Evol; 2010 Jan; 27(1):177-92. PubMed ID: 19759235
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Mutations within lncRNAs are effectively selected against in fruitfly but not in human.
    Haerty W; Ponting CP
    Genome Biol; 2013 May; 14(5):R49. PubMed ID: 23710818
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Calibrating the Human Mutation Rate via Ancestral Recombination Density in Diploid Genomes.
    Lipson M; Loh PR; Sankararaman S; Patterson N; Berger B; Reich D
    PLoS Genet; 2015 Nov; 11(11):e1005550. PubMed ID: 26562831
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Estimating the rate of adaptive molecular evolution in the presence of slightly deleterious mutations and population size change.
    Eyre-Walker A; Keightley PD
    Mol Biol Evol; 2009 Sep; 26(9):2097-108. PubMed ID: 19535738
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.