171 related articles for article (PubMed ID: 22365751)
1. Synthesis and evaluation of a new series of 1'-cyclobutyl-6-(4-piperidyloxy)spiro[benzopyran-2,4'-piperidine] derivatives as high affinity and selective histamine-3 receptor (H3R) antagonists.
Dandu RR; Lyons JA; Raddatz R; Huang Z; Aimone LD; Hudkins RL
Bioorg Med Chem Lett; 2012 Mar; 22(6):2151-3. PubMed ID: 22365751
[TBL] [Abstract][Full Text] [Related]
2. Synthesis and evaluation of 4-alkoxy-[1'-cyclobutyl-spiro(3,4-dihydrobenzopyran-2,4'-piperidine)] analogues as histamine-3 receptor antagonists.
Becknell NC; Dandu RR; Lyons JA; Aimone LD; Raddatz R; Hudkins RL
Bioorg Med Chem Lett; 2012 Jan; 22(1):186-9. PubMed ID: 22153342
[TBL] [Abstract][Full Text] [Related]
3. Novel nonimidazole histamine H3 receptor antagonists: 1-(4-(phenoxymethyl)benzyl)piperidines and related compounds.
Mikó T; Ligneau X; Pertz HH; Ganellin CR; Arrang JM; Schwartz JC; Schunack W; Stark H
J Med Chem; 2003 Apr; 46(8):1523-30. PubMed ID: 12672253
[TBL] [Abstract][Full Text] [Related]
4. Synthesis and structure-activity relationships for biphenyl H3 receptor antagonists with moderate anti-cholinesterase activity.
Morini G; Comini M; Rivara M; Rivara S; Bordi F; Plazzi PV; Flammini L; Saccani F; Bertoni S; Ballabeni V; Barocelli E; Mor M
Bioorg Med Chem; 2008 Dec; 16(23):9911-24. PubMed ID: 18976927
[TBL] [Abstract][Full Text] [Related]
5. Discovery of spirofused piperazine and diazepane amides as selective histamine-3 antagonists with in vivo efficacy in a mouse model of cognition.
Brown DG; Bernstein PR; Griffin A; Wesolowski S; Labrecque D; Tremblay MC; Sylvester M; Mauger R; Edwards PD; Throner SR; Folmer JJ; Cacciola J; Scott C; Lazor LA; Pourashraf M; Santhakumar V; Potts WM; Sydserff S; Giguère P; Lévesque C; Dasser M; Groblewski T
J Med Chem; 2014 Feb; 57(3):733-58. PubMed ID: 24410637
[TBL] [Abstract][Full Text] [Related]
6. A new class of diamine-based human histamine H3 receptor antagonists: 4-(aminoalkoxy)benzylamines.
Apodaca R; Dvorak CA; Xiao W; Barbier AJ; Boggs JD; Wilson SJ; Lovenberg TW; Carruthers NI
J Med Chem; 2003 Aug; 46(18):3938-44. PubMed ID: 12930154
[TBL] [Abstract][Full Text] [Related]
7. Reduction of hERG inhibitory activity in the 4-piperidinyl urea series of H3 antagonists.
Berlin M; Lee YJ; Boyce CW; Wang Y; Aslanian R; McCormick KD; Sorota S; Williams SM; West RE; Korfmacher W
Bioorg Med Chem Lett; 2010 Apr; 20(7):2359-64. PubMed ID: 20188550
[TBL] [Abstract][Full Text] [Related]
8. Reduction of CYP450 inhibition in the 4-[(1H-imidazol-4-yl)methyl]piperidine series of histamine H3 receptor antagonists.
Berlin M; Ting PC; Vaccaro WD; Aslanian R; McCormick KD; Lee JF; Albanese MM; Mutahi MW; Piwinski JJ; Shih NY; Duguma L; Solomon DM; Zhou W; Sher R; Favreau L; Bryant M; Korfmacher WA; Nardo C; West RE; Anthes JC; Williams SM; Wu RL; Susan She H; Rivelli MA; Corboz MR; Hey JA
Bioorg Med Chem Lett; 2006 Feb; 16(4):989-94. PubMed ID: 16297617
[TBL] [Abstract][Full Text] [Related]
9. Novel histamine H3 receptor antagonists based on the 4-[(1H-imidazol-4-yl)methyl]piperidine scaffold.
Vaccaro WD; Sher R; Berlin M; Shih NY; Aslanian R; Schwerdt JH; McCormick KD; Piwinski JJ; West RE; Anthes JC; Williams SM; Wu RL; She HS; Rivelli MA; Mutter JC; Corboz MR; Hey JA; Favreau L
Bioorg Med Chem Lett; 2006 Jan; 16(2):395-9. PubMed ID: 16246552
[TBL] [Abstract][Full Text] [Related]
10. New 1-benzyl-4-hydroxypiperidine derivatives as non-imidazole histamine H3 receptor antagonists.
Maslowska-Lipowicz I; Figlus M; Zuiderveld OP; Walczynski K
Arch Pharm (Weinheim); 2008 Dec; 341(12):762-73. PubMed ID: 19009544
[TBL] [Abstract][Full Text] [Related]
11. Synthesis and structure-activity relationship of spiro[isochroman-piperidine] analogs for inhibition of histamine release. IV.
Hashigaki K; Hiramatsu K; Yamato M; Tasaka K
Chem Pharm Bull (Tokyo); 1984 Sep; 32(9):3561-8. PubMed ID: 6084557
[No Abstract] [Full Text] [Related]
12. Piperidine-containing histamine H3 receptor antagonists of the carbamate series: the influence of the additional ether functionality.
Łazewska D; Kieć-Kononowicz K; Pertz HH; Elz S; Stark H; Schunack W
Pharmazie; 2002 Dec; 57(12):791-5. PubMed ID: 12561236
[TBL] [Abstract][Full Text] [Related]
13. Development of trans-2-[1H-imidazol-4-yl] cyclopropane derivatives as new high-affinity histamine H3 receptor ligands.
Tedford CE; Phillips JG; Gregory R; Pawlowski GP; Fadnis L; Khan MA; Ali SM; Handley MK; Yates SL
J Pharmacol Exp Ther; 1999 May; 289(2):1160-8. PubMed ID: 10215700
[TBL] [Abstract][Full Text] [Related]
14. Synthesis and in vitro pharmacology of a series of new chiral histamine H3-receptor ligands: 2-(R and S)-Amino-3-(1H-imidazol-4(5)-yl)propyl ether derivatives.
Kovalainen JT; Christiaans JA; Kotisaari S; Laitinen JT; Männistö PT; Tuomisto L; Gynther J
J Med Chem; 1999 Apr; 42(7):1193-202. PubMed ID: 10197963
[TBL] [Abstract][Full Text] [Related]
15. Synthesis and structure-activity relationships of conformationally constrained histamine H(3) receptor agonists.
Kitbunnadaj R; Zuiderveld OP; De Esch IJ; Vollinga RC; Bakker R; Lutz M; Spek AL; Cavoy E; Deltent MF; Menge WM; Timmerman H; Leurs R
J Med Chem; 2003 Dec; 46(25):5445-57. PubMed ID: 14640553
[TBL] [Abstract][Full Text] [Related]
16. 3-(1'-Cyclobutylspiro[4H-1,3-benzodioxine-2,4'-piperidine]-6-yl)-5,5-dimethyl-1,4-dihydropyridazin-6-one (CEP-32215), a new wake-promoting histamine H3 antagonist/inverse agonist.
Hudkins RL; Gruner JA; Raddatz R; Mathiasen JR; Aimone LD; Marino MJ; Bacon ER; Williams M; Ator MA
Neuropharmacology; 2016 Jul; 106():37-45. PubMed ID: 26400408
[TBL] [Abstract][Full Text] [Related]
17. Structurally novel histamine H3 receptor antagonists GSK207040 and GSK334429 improve scopolamine-induced memory impairment and capsaicin-induced secondary allodynia in rats.
Medhurst AD; Briggs MA; Bruton G; Calver AR; Chessell I; Crook B; Davis JB; Davis RP; Foley AG; Heslop T; Hirst WD; Medhurst SJ; Ociepka S; Ray A; Regan CM; Sargent B; Schogger J; Stean TO; Trail BK; Upton N; White T; Orlek B; Wilson DM
Biochem Pharmacol; 2007 Apr; 73(8):1182-94. PubMed ID: 17276409
[TBL] [Abstract][Full Text] [Related]
18. Discovery and characterization of 6-{4-[3-(R)-2-methylpyrrolidin-1-yl)propoxy]phenyl}-2H-pyridazin-3-one (CEP-26401, irdabisant): a potent, selective histamine H3 receptor inverse agonist.
Hudkins RL; Raddatz R; Tao M; Mathiasen JR; Aimone LD; Becknell NC; Prouty CP; Knutsen LJ; Yazdanian M; Moachon G; Ator MA; Mallamo JP; Marino MJ; Bacon ER; Williams M
J Med Chem; 2011 Jul; 54(13):4781-92. PubMed ID: 21634396
[TBL] [Abstract][Full Text] [Related]
19. Synthesis and evaluation of 4- and 5-pyridazin-3-one phenoxypropylamine analogues as histamine-3 receptor antagonists.
Becknell NC; Lyons JA; Aimone LD; Huang Z; Gruner JA; Raddatz R; Hudkins RL
Bioorg Med Chem; 2012 Jun; 20(12):3880-6. PubMed ID: 22578490
[TBL] [Abstract][Full Text] [Related]
20. 3-amino-3,4-dihydro-2H-1-benzopyran derivatives as 5-HT1A receptor ligands and potential anxiolytic agents. 2. Synthesis and quantitative structure-activity relationship studies of spiro[pyrrolidine- and piperidine-2,3'(2'H)-benzopyrans].
Comoy C; Marot C; Podona T; Baudin ML; Morin-Allory L; Guillaumet G; Pfeiffer B; Caignard DH; Renard P; Rettori MC; Adam G; Guardiola-Lemaitre B
J Med Chem; 1996 Oct; 39(21):4285-98. PubMed ID: 8863806
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
