BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

179 related articles for article (PubMed ID: 22370634)

  • 1. MNK kinases facilitate c-myc IRES activity in rapamycin-treated multiple myeloma cells.
    Shi Y; Frost P; Hoang B; Yang Y; Fukunaga R; Gera J; Lichtenstein A
    Oncogene; 2013 Jan; 32(2):190-7. PubMed ID: 22370634
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Cyclin D1 and c-myc internal ribosome entry site (IRES)-dependent translation is regulated by AKT activity and enhanced by rapamycin through a p38 MAPK- and ERK-dependent pathway.
    Shi Y; Sharma A; Wu H; Lichtenstein A; Gera J
    J Biol Chem; 2005 Mar; 280(12):10964-73. PubMed ID: 15634685
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Regulation of D-cyclin translation inhibition in myeloma cells treated with mammalian target of rapamycin inhibitors: rationale for combined treatment with extracellular signal-regulated kinase inhibitors and rapamycin.
    Frost P; Shi Y; Hoang B; Gera J; Lichtenstein A
    Mol Cancer Ther; 2009 Jan; 8(1):83-93. PubMed ID: 19139116
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Mnk mediates integrin α6β4-dependent eIF4E phosphorylation and translation of VEGF mRNA.
    Korneeva NL; Soung YH; Kim HI; Giordano A; Rhoads RE; Gram H; Chung J
    Mol Cancer Res; 2010 Dec; 8(12):1571-8. PubMed ID: 21047768
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Internal ribosome entry segment-mediated initiation of c-Myc protein synthesis following genotoxic stress.
    Subkhankulova T; Mitchell SA; Willis AE
    Biochem J; 2001 Oct; 359(Pt 1):183-92. PubMed ID: 11563982
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Therapeutic potential of targeting IRES-dependent c-myc translation in multiple myeloma cells during ER stress.
    Shi Y; Yang Y; Hoang B; Bardeleben C; Holmes B; Gera J; Lichtenstein A
    Oncogene; 2016 Feb; 35(8):1015-24. PubMed ID: 25961916
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The androgen receptor is a negative regulator of eIF4E phosphorylation at S209: implications for the use of mTOR inhibitors in advanced prostate cancer.
    D'Abronzo LS; Bose S; Crapuchettes ME; Beggs RE; Vinall RL; Tepper CG; Siddiqui S; Mudryj M; Melgoza FU; Durbin-Johnson BP; deVere White RW; Ghosh PM
    Oncogene; 2017 Nov; 36(46):6359-6373. PubMed ID: 28745319
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Simultaneous inhibition of mTOR-containing complex 1 (mTORC1) and MNK induces apoptosis of cutaneous T-cell lymphoma (CTCL) cells.
    Marzec M; Liu X; Wysocka M; Rook AH; Odum N; Wasik MA
    PLoS One; 2011; 6(9):e24849. PubMed ID: 21949767
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Inhibition of mammalian target of rapamycin induces phosphatidylinositol 3-kinase-dependent and Mnk-mediated eukaryotic translation initiation factor 4E phosphorylation.
    Wang X; Yue P; Chan CB; Ye K; Ueda T; Watanabe-Fukunaga R; Fukunaga R; Fu H; Khuri FR; Sun SY
    Mol Cell Biol; 2007 Nov; 27(21):7405-13. PubMed ID: 17724079
    [TBL] [Abstract][Full Text] [Related]  

  • 10. CGP57380 enhances efficacy of RAD001 in non-small cell lung cancer through abrogating mTOR inhibition-induced phosphorylation of eIF4E and activating mitochondrial apoptotic pathway.
    Wen Q; Wang W; Luo J; Chu S; Chen L; Xu L; Zang H; Alnemah MM; Ma J; Fan S
    Oncotarget; 2016 May; 7(19):27787-801. PubMed ID: 27050281
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Tristetraprolin regulates Cyclin D1 and c-Myc mRNA stability in response to rapamycin in an Akt-dependent manner via p38 MAPK signaling.
    Marderosian M; Sharma A; Funk AP; Vartanian R; Masri J; Jo OD; Gera JF
    Oncogene; 2006 Oct; 25(47):6277-90. PubMed ID: 16702957
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Inhibition of Mitogen-activated Protein Kinase (MAPK)-interacting Kinase (MNK) Preferentially Affects Translation of mRNAs Containing Both a 5'-Terminal Cap and Hairpin.
    Korneeva NL; Song A; Gram H; Edens MA; Rhoads RE
    J Biol Chem; 2016 Feb; 291(7):3455-67. PubMed ID: 26668315
    [TBL] [Abstract][Full Text] [Related]  

  • 13. MAP kinase-interacting kinase 1 regulates SMAD2-dependent TGF-β signaling pathway in human glioblastoma.
    Grzmil M; Morin P; Lino MM; Merlo A; Frank S; Wang Y; Moncayo G; Hemmings BA
    Cancer Res; 2011 Mar; 71(6):2392-402. PubMed ID: 21406405
    [TBL] [Abstract][Full Text] [Related]  

  • 14. MNK1 pathway activity maintains protein synthesis in rapalog-treated gliomas.
    Grzmil M; Huber RM; Hess D; Frank S; Hynx D; Moncayo G; Klein D; Merlo A; Hemmings BA
    J Clin Invest; 2014 Feb; 124(2):742-54. PubMed ID: 24401275
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Ras transformation of RIE-1 cells activates cap-independent translation of ornithine decarboxylase: regulation by the Raf/MEK/ERK and phosphatidylinositol 3-kinase pathways.
    Origanti S; Shantz LM
    Cancer Res; 2007 May; 67(10):4834-42. PubMed ID: 17510413
    [TBL] [Abstract][Full Text] [Related]  

  • 16. IL-6-induced stimulation of c-myc translation in multiple myeloma cells is mediated by myc internal ribosome entry site function and the RNA-binding protein, hnRNP A1.
    Shi Y; Frost PJ; Hoang BQ; Benavides A; Sharma S; Gera JF; Lichtenstein AK
    Cancer Res; 2008 Dec; 68(24):10215-22. PubMed ID: 19074889
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The MNK-1/eIF4E pathway as a new therapeutic pathway to target inflammation and remodelling in asthma.
    Seidel P; Sun Q; Costa L; Lardinois D; Tamm M; Roth M
    Cell Signal; 2016 Oct; 28(10):1555-62. PubMed ID: 27418099
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Mechanistic Target of Rapamycin (mTOR) Inhibition Synergizes with Reduced Internal Ribosome Entry Site (IRES)-mediated Translation of Cyclin D1 and c-MYC mRNAs to Treat Glioblastoma.
    Holmes B; Lee J; Landon KA; Benavides-Serrato A; Bashir T; Jung ME; Lichtenstein A; Gera J
    J Biol Chem; 2016 Jul; 291(27):14146-14159. PubMed ID: 27226604
    [TBL] [Abstract][Full Text] [Related]  

  • 19. MNK1 inhibitor CGP57380 overcomes mTOR inhibitor-induced activation of eIF4E: the mechanism of synergic killing of human T-ALL cells.
    Huang XB; Yang CM; Han QM; Ye XJ; Lei W; Qian WB
    Acta Pharmacol Sin; 2018 Dec; 39(12):1894-1901. PubMed ID: 30297804
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Critical Role for Cap-Independent c-MYC Translation in Progression of Multiple Myeloma.
    Shi Y; Sun F; Cheng Y; Holmes B; Dhakal B; Gera JF; Janz S; Lichtenstein A
    Mol Cancer Ther; 2022 Apr; 21(4):502-510. PubMed ID: 35086951
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.