These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

208 related articles for article (PubMed ID: 22371504)

  • 1. Structural basis for dual nucleotide selectivity of aminoglycoside 2''-phosphotransferase IVa provides insight on determinants of nucleotide specificity of aminoglycoside kinases.
    Shi K; Berghuis AM
    J Biol Chem; 2012 Apr; 287(16):13094-102. PubMed ID: 22371504
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Revisiting the nucleotide and aminoglycoside substrate specificity of the bifunctional aminoglycoside acetyltransferase(6')-Ie/aminoglycoside phosphotransferase(2'')-Ia enzyme.
    Frase H; Toth M; Vakulenko SB
    J Biol Chem; 2012 Dec; 287(52):43262-9. PubMed ID: 23115238
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Aminoglycoside 2''-phosphotransferase IIIa (APH(2'')-IIIa) prefers GTP over ATP: structural templates for nucleotide recognition in the bacterial aminoglycoside-2'' kinases.
    Smith CA; Toth M; Frase H; Byrnes LJ; Vakulenko SB
    J Biol Chem; 2012 Apr; 287(16):12893-903. PubMed ID: 22367198
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Crystal structure and kinetic mechanism of aminoglycoside phosphotransferase-2''-IVa.
    Toth M; Frase H; Antunes NT; Smith CA; Vakulenko SB
    Protein Sci; 2010 Aug; 19(8):1565-76. PubMed ID: 20556826
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structural basis for the diversity of the mechanism of nucleotide hydrolysis by the aminoglycoside-2''-phosphotransferases.
    Smith CA; Toth M; Stewart NK; Maltz L; Vakulenko SB
    Acta Crystallogr D Struct Biol; 2019 Dec; 75(Pt 12):1129-1137. PubMed ID: 31793906
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Crystal structures of antibiotic-bound complexes of aminoglycoside 2''-phosphotransferase IVa highlight the diversity in substrate binding modes among aminoglycoside kinases.
    Shi K; Houston DR; Berghuis AM
    Biochemistry; 2011 Jul; 50(28):6237-44. PubMed ID: 21678960
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The crystal structures of substrate and nucleotide complexes of Enterococcus faecium aminoglycoside-2''-phosphotransferase-IIa [APH(2'')-IIa] provide insights into substrate selectivity in the APH(2'') subfamily.
    Young PG; Walanj R; Lakshmi V; Byrnes LJ; Metcalf P; Baker EN; Vakulenko SB; Smith CA
    J Bacteriol; 2009 Jul; 191(13):4133-43. PubMed ID: 19429619
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Novel aminoglycoside 2''-phosphotransferase identified in a gram-negative pathogen.
    Toth M; Frase H; Antunes NT; Vakulenko SB
    Antimicrob Agents Chemother; 2013 Jan; 57(1):452-7. PubMed ID: 23129050
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Bulky "gatekeeper" residue changes the cosubstrate specificity of aminoglycoside 2''-phosphotransferase IIa.
    Bhattacharya M; Toth M; Smith CA; Vakulenko SB
    Antimicrob Agents Chemother; 2013 Aug; 57(8):3763-6. PubMed ID: 23716051
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Aminoglycoside binding and catalysis specificity of aminoglycoside 2″-phosphotransferase IVa: A thermodynamic, structural and kinetic study.
    Kaplan E; Guichou JF; Chaloin L; Kunzelmann S; Leban N; Serpersu EH; Lionne C
    Biochim Biophys Acta; 2016 Apr; 1860(4):802-13. PubMed ID: 26802312
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Aminoglycoside 2''-phosphotransferase type IIIa from Enterococcus.
    Badarau A; Shi Q; Chow JW; Zajicek J; Mobashery S; Vakulenko S
    J Biol Chem; 2008 Mar; 283(12):7638-47. PubMed ID: 18199745
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Active site labeling of the gentamicin resistance enzyme AAC(6')-APH(2") by the lipid kinase inhibitor wortmannin.
    Boehr DD; Lane WS; Wright GD
    Chem Biol; 2001 Aug; 8(8):791-800. PubMed ID: 11514228
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structure of the antibiotic resistance factor spectinomycin phosphotransferase from Legionella pneumophila.
    Fong DH; Lemke CT; Hwang J; Xiong B; Berghuis AM
    J Biol Chem; 2010 Mar; 285(13):9545-9555. PubMed ID: 20089863
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Source of phosphate in the enzymic reaction as a point of distinction among aminoglycoside 2''-phosphotransferases.
    Toth M; Chow JW; Mobashery S; Vakulenko SB
    J Biol Chem; 2009 Mar; 284(11):6690-6. PubMed ID: 19158087
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Structure and function of APH(4)-Ia, a hygromycin B resistance enzyme.
    Stogios PJ; Shakya T; Evdokimova E; Savchenko A; Wright GD
    J Biol Chem; 2011 Jan; 286(3):1966-75. PubMed ID: 21084294
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structure of an enzyme required for aminoglycoside antibiotic resistance reveals homology to eukaryotic protein kinases.
    Hon WC; McKay GA; Thompson PR; Sweet RM; Yang DS; Wright GD; Berghuis AM
    Cell; 1997 Jun; 89(6):887-95. PubMed ID: 9200607
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Antibiotic Binding Drives Catalytic Activation of Aminoglycoside Kinase APH(2″)-Ia.
    Caldwell SJ; Huang Y; Berghuis AM
    Structure; 2016 Jun; 24(6):935-45. PubMed ID: 27161980
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Nucleotide selectivity of antibiotic kinases.
    Shakya T; Wright GD
    Antimicrob Agents Chemother; 2010 May; 54(5):1909-13. PubMed ID: 20231391
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Active-site labeling of an aminoglycoside antibiotic phosphotransferase (APH(3')-IIIa).
    McKay GA; Robinson RA; Lane WS; Wright GD
    Biochemistry; 1994 Nov; 33(47):14115-20. PubMed ID: 7947822
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Crystal structures of two aminoglycoside kinases bound with a eukaryotic protein kinase inhibitor.
    Fong DH; Xiong B; Hwang J; Berghuis AM
    PLoS One; 2011 May; 6(5):e19589. PubMed ID: 21573013
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.